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The map label for this gene is coaA [H]

Identifier: 218904019

GI number: 218904019

Start: 2747154

End: 2747984

Strand: Direct

Name: coaA [H]

Synonym: BCAH820_2903

Alternate gene names: 218904019

Gene position: 2747154-2747984 (Clockwise)

Preceding gene: 218904018

Following gene: 218904027

Centisome position: 51.81

GC content: 31.77

Gene sequence:

>831_bases
ATGGAAAGTACGATCGGTATCGATGCTGGAGGAACATTAACAAAAATTGCTTATTTAAACGAAAAAAAGAAATTAACTTT
TGAAAAATTTTATTCAAATGAACAAGATAAAATAATAGATTGGCTTAAGAAGCAAACCAGTATAAAACAAATATGTATTA
CTGGTGGTAAAGCGAAACAATTACAGCAACTACTTTCAGACTCATATAAAATAGTAGAACTAAACGAATTTGAAGCTACT
CTTGTAGGTGTCCGATACATATTAAAAGAAGAAAAATATGATATAAACAACTTTGTTTTAACAAATATCGGTACAGGTAC
CTCCATTCATTACATTTATAATGACCGATATATTCGCGCTGGTGGAACCGGTGTTGGCGGAGGTACTATTATGGGACTTT
CAAAATTATTAACAAATATAGATCATTTTGAAGATGTGATTCCTTTAACAAAAGTGGGTTCTAGAAAAGATTTAGATATT
ACAGTTGGAGATATTTATGGTGGGATTCTCTCCCCTATTGATAATAGTTTAACTGCAAGCAATTTTGGTAAAGCCGCTAC
TATAGAATCAAATTATAATAACTCAGATATACTTGCTACTGTACAAGGACTTGTCGGTGAAGTCGTTACTGCATTAAGCC
TTCAATTCGCCGAAACAAAAAACATTGGCCATATTATTTATATTGGTTCGACTCTATGTAATAACATACATCTTCAAAAT
ATTATTAGTAGTTACACAAAATACCAAAATAAAACACCCATCTTTTTACGAGATGGTGGTAATAGCGGTGCGATTGGTGC
TTTACTTTATGCTACGAATAAAAAAAGCTGA

Upstream 100 bases:

>100_bases
CAGAATAGAGACCTTTTTATTCACTAGGGTATCTATCTCCTACCAATTCGTTTCATCAACATGAACAGAGTAAATAAATT
ACTTAGTTAGGAGCAGGCAA

Downstream 100 bases:

>100_bases
CTTTTGTCAGCTTTTTTGCAACGGTACTTCAAATTCAATAATTGATTCCCCCTTTTCTCCAATTCGCTCTACACTAATTC
TATCAATTACACATTGTAAC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-II; Pantothenic acid kinase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MESTIGIDAGGTLTKIAYLNEKKKLTFEKFYSNEQDKIIDWLKKQTSIKQICITGGKAKQLQQLLSDSYKIVELNEFEAT
LVGVRYILKEEKYDINNFVLTNIGTGTSIHYIYNDRYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKDLDI
TVGDIYGGILSPIDNSLTASNFGKAATIESNYNNSDILATVQGLVGEVVTALSLQFAETKNIGHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS

Sequences:

>Translated_276_residues
MESTIGIDAGGTLTKIAYLNEKKKLTFEKFYSNEQDKIIDWLKKQTSIKQICITGGKAKQLQQLLSDSYKIVELNEFEAT
LVGVRYILKEEKYDINNFVLTNIGTGTSIHYIYNDRYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKDLDI
TVGDIYGGILSPIDNSLTASNFGKAATIESNYNNSDILATVQGLVGEVVTALSLQFAETKNIGHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
>Mature_276_residues
MESTIGIDAGGTLTKIAYLNEKKKLTFEKFYSNEQDKIIDWLKKQTSIKQICITGGKAKQLQQLLSDSYKIVELNEFEAT
LVGVRYILKEEKYDINNFVLTNIGTGTSIHYIYNDRYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKDLDI
TVGDIYGGILSPIDNSLTASNFGKAATIESNYNNSDILATVQGLVGEVVTALSLQFAETKNIGHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis [H]

COG id: COG5146

COG function: function code H; Pantothenate kinase, acetyl-CoA regulated

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II pantothenate kinase family [H]

Homologues:

Organism=Homo sapiens, GI8922665, Length=330, Percent_Identity=25.4545454545455, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI23510402, Length=300, Percent_Identity=26, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI23510400, Length=300, Percent_Identity=25.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI24430175, Length=258, Percent_Identity=27.5193798449612, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI24430167, Length=258, Percent_Identity=27.5193798449612, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI85838513, Length=299, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI13375789, Length=192, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32565377, Length=330, Percent_Identity=24.2424242424242, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144310, Length=330, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144312, Length=219, Percent_Identity=27.3972602739726, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20544160, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667450, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667454, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20544156, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17864532, Length=289, Percent_Identity=28.3737024221453, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011602
- InterPro:   IPR014642
- InterPro:   IPR004567 [H]

Pfam domain/function: PF03630 Fumble [H]

EC number: =2.7.1.33 [H]

Molecular weight: Translated: 30210; Mature: 30210

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTIGIDAGGTLTKIAYLNEKKKLTFEKFYSNEQDKIIDWLKKQTSIKQICITGGKAKQ
CCCCEECCCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCHHH
LQQLLSDSYKIVELNEFEATLVGVRYILKEEKYDINNFVLTNIGTGTSIHYIYNDRYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCEEEEE
GGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKDLDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEHHHHHHHHHHCCCCCCCC
NFGKAATIESNYNNSDILATVQGLVGEVVTALSLQFAETKNIGHIIYIGSTLCNNIHLQN
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MESTIGIDAGGTLTKIAYLNEKKKLTFEKFYSNEQDKIIDWLKKQTSIKQICITGGKAKQ
CCCCEECCCCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCHHH
LQQLLSDSYKIVELNEFEATLVGVRYILKEEKYDINNFVLTNIGTGTSIHYIYNDRYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCEEEEE
GGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKDLDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEHHHHHHHHHHCCCCCCCC
NFGKAATIESNYNNSDILATVQGLVGEVVTALSLQFAETKNIGHIIYIGSTLCNNIHLQN
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]