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The map label for this gene is kynU [H]

Identifier: 218903877

GI number: 218903877

Start: 2632261

End: 2633547

Strand: Reverse

Name: kynU [H]

Synonym: BCAH820_2761

Alternate gene names: 218903877

Gene position: 2633547-2632261 (Counterclockwise)

Preceding gene: 218903879

Following gene: 218903876

Centisome position: 49.66

GC content: 36.67

Gene sequence:

>1287_bases
ATGTATAAAGAACCATTTCAACCAACTTATGAGTATGCGCTTGAATGTGATAAACATGATGAACTGAAAGATTTTCAAAC
TGAATTTTATAAAAAAGAAGGAACAATATATTTAGATGGAAACTCATTAGGGCTACTTTCAAAAAGAGCAGAGAAATCAT
TACTTACTTTGCTAGATTCATGGAAAGAGTATGGCATTGACGGCTGGACCGAGGGTGAGCATCCGTGGTTTTTCCTTTCG
GAGAAATTAGGTGAATTGACTGCACCTCTTATTGGAGCTTTACCAGAAGAAACTATTGTAACCGGTTCCACGACAACGAA
TATTCATCAAGTAATCGCAACTTTCTATGAGCCGAAAGGAATTCGGACAAAAATTCTTGCGGATGAATTAACATTTCCGT
CAGATATATATGCACTTCAAAGTCAAATTCGCTTAAAGGGCCTAGATCCAGATGAGCATTTAGTACGAGTGAAGAGCCGA
GACGGTAGAACACTTTCTGAAGATGATATTATTCAAGCAATGACAGATGACATCGCGTTAATTTTATTGCCTTCTGTACT
ATATAGAAGTGGACAAATTCTTGATATGAAACGTTTAACAGCGGAAGCTCATGAGCGTGGTATTCATATCGGGTTCGATT
TATGTCACTCAATCGGTTCTATTCCGCATCATTTCAAAGAATGGGATGTTGACTTTGCTATTTGGTGTAATTATAAATAC
TTAAACGCAGGACCTGGCGGTGTTGCTGGCCTTTATGTAAATAAAAAGCATTTTAATAGACTTCCAGGCTTGTCTGGCTG
GTTTAGTTCTAGAAAAGATAAGCAGTTTGATATGGAACATACATTAACAGCTGCTGATCATGCAGGGGCGTATCAAATTG
GTACACCGCACATATTAAGTACTGCACCTTTAATTGGTTCACTTGAAATATTTAAAGATGCTGGTATAGAACGTTTACGT
GAAAAATCCTTACATATTACAAGATACATGCTTAATTTGATTGACCATGAATTAAAAGATTTCGGATTTACAATTGGAAA
TCCATTTGAGGATGAAAAACGAGGCGGGCATATTTATTTAGAGCATGCAGAAGCAGCACGTATATGTAAAGCGTTAAAAG
CAAATGGAGTAATTCCAGATTTTAGAGCGCCAAATGGAGTGAGACTTGCGCCAGTTGCTTTATATAATACGTACGAAGAA
GTATGGCAGTCTGTTATGATTTTAAAGAAAATTATGAAAGATGAAGAGTATAAGCAATTTGAAAATAAGCGAGAGGTTGT
GGCATAA

Upstream 100 bases:

>100_bases
TATATAAAGTCAACTGACATAATATCATTGACGTTATATCAACTAAGGTGATATATTTCAATTAGTTAGAATAAAAAGAA
AATTAAGAGAAGGTGACACC

Downstream 100 bases:

>100_bases
GTATGAAAACATCAGAGTGGATTGATATTTCACAACCGCTAAATAATGATATTGCTACTTGGCCAGGGGATACACCGTTC
TCGTATGAAGTATCATGGTC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHERGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHILSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA

Sequences:

>Translated_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHERGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHILSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA
>Mature_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHERGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHILSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=443, Percent_Identity=35.2144469525959, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=35.7894736842105, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550466, Length=391, Percent_Identity=35.8056265984655, Blast_Score=259, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6323261, Length=449, Percent_Identity=34.9665924276169, Blast_Score=247, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48738; Mature: 48738

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIQAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLPSVLYRSGQILDMKRLTAEAHERGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHILS
EECCCCCEEEEEEEHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWQSVMILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC
>Mature Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIQAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLPSVLYRSGQILDMKRLTAEAHERGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHILS
EECCCCCEEEEEEEHHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWQSVMILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA