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The map label for this gene is flp [H]

Identifier: 218903703

GI number: 218903703

Start: 2459740

End: 2461131

Strand: Direct

Name: flp [H]

Synonym: BCAH820_2587

Alternate gene names: 218903703

Gene position: 2459740-2461131 (Clockwise)

Preceding gene: 218903702

Following gene: 218903704

Centisome position: 46.39

GC content: 31.25

Gene sequence:

>1392_bases
ATGCTATGTATCACACATCCAAAAGTTTACGCTCAGCAAAATGTTAAAGTTACATTAGATAAGTATATTGAAAAATTTAT
AAAGGAACAGAATATTCCAGGAGCTGCTGTTGCAATTGTACATAATAAAGAAGTATTCTTCACAAAAACGATGGGGGTTA
CTGGAGAATCTGAAAAAAAGGTAACTAGTAAAACGCCATTTGCAATCGGCTCAATAAGTAAATCTTTAACAGCTTTAGCT
ATAGTGAAATTAATAGAAGATAAAAAAATAAAATTAGAGGATCCAGTTCAACGATATCTCCCCTGGTTTAAACTAAAAAA
CCCTCAAATATCCTCAACTATAACAATCCAACATCTACTAACTCATACAAGCGGAATCAACACATATGAGGGCTTAGCAT
TATCAGATAAGCAATCCAAAAGTTCTACAGCATTAAAAGAAAATGTAATGAAGCTTTCAAATGTAAAAGTAACTGCTCCA
CCAGGTGAGAAATATCAATATAGTAATGCAAATTATATTGTTTTAGGCGCACTTATTGAAGAAGTCACAAATGAAACATA
TTCATCATATATGGAAAAGTATATTTTTCAGCCGTTAAATATGAATGGCGCGGCAGCAAGTAAAGAAACTGCATATAAAA
AAGGTTATTTAACAGGTTATCAGTCTTGGTTTGGCATTCCAAGAAAAAGTGTAGTGTCCTATGATAATGCCGGGGCACCG
TATGGCTATATTACTGCAAATTTAGAAGATATGATTCAATATATTATGTTTTTGAATCGTCCAGAGGATGCTCAATTATT
AAAGCAAGAAAATATGCATCTTTATCTATCACCACTTTATAAGATAAATTCAGAAAAAAGTTATGGTTTTGGATTAAGAA
CAACAAATATAAATGAAAGTGAAACGATGATTTGGCATTCAGGATCAACGCCCGATGCTCGTGCAGAATTATTTACTTTA
AACGAAAGTGGCTGGAGTGGAGTAATTTTAACAAATAAAAATCATGTATTAGAAGAAACAGCACTATCAGTATTGAAAAA
GGGTATTATTAGTATTTTGAATGGAGAAGAACCGGTTGATATCCCTAAAAAAATACCATTAACACAAATTATTTTGTTGG
TAGTTACACTCATACTTTTCATAATATCAATTATGTTAATTAAAAAGTATAAACATATGAAAACTGTAAAAAAGGTAATT
TGGTTATTCATAGGGAGTCTATCCCTACTATTATCTATTATTTTTATCCCACTGCTTACTTATAGTACGAGTTCACCTTG
GCGTACGATTAAAATATTTGCGCCAGACGTAGCTTTATTTACAAGTATTAGTGTAACTTTATTAGCTGTTAACGGACTAA
TATCAATTCTTATAGCTTTAAGAAGGAAGTAA

Upstream 100 bases:

>100_bases
TATATTAGCTTAGTAAGTTATAAAAAAAGAAAGCATCTAAAGTATAATGAAGAATGCGATCTATAAAGTCTTTCTAATTT
GTATTCTTTGTAATGTATTT

Downstream 100 bases:

>100_bases
GTAGAAGGGGAAAGAATGAAAGAAATATAAGTTAAGTGTTAGAAACAGTTGACTCTCACACAATGTCATTGTTTAAGATG
AAGTTGAACTTCGAAGTAGA

Product: putative penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALA
IVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAP
PGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQSWFGIPRKSVVSYDNAGAP
YGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESETMIWHSGSTPDARAELFTL
NESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVI
WLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISILIALRRK

Sequences:

>Translated_463_residues
MLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALA
IVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAP
PGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQSWFGIPRKSVVSYDNAGAP
YGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESETMIWHSGSTPDARAELFTL
NESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVI
WLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISILIALRRK
>Mature_463_residues
MLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVTSKTPFAIGSISKSLTALA
IVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAP
PGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQSWFGIPRKSVVSYDNAGAP
YGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESETMIWHSGSTPDARAELFTL
NESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVI
WLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISILIALRRK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=259, Percent_Identity=28.957528957529, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550934, Length=338, Percent_Identity=26.3313609467456, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533026, Length=376, Percent_Identity=23.936170212766, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 51922; Mature: 51922

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKK
CEEECCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEECCCCCCCCCC
VTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLL
CCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEECCCCCCHHEEHHHHH
THTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIE
HHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCCCCEEECCCCEEEHHHHHH
EVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQSWFGIPRKSVVSYDNAGAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCHHHCCCCCCCCC
YGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINES
CEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEECCCCCCCCEEEECCCCCC
ETMIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVD
CEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISILIALRRK
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLCITHPKVYAQQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKK
CEEECCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEECCCCCCCCCC
VTSKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLL
CCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEECCCCCCHHEEHHHHH
THTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTAPPGEKYQYSNANYIVLGALIE
HHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCEEEECCCCCCEEECCCCEEEHHHHHH
EVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQSWFGIPRKSVVSYDNAGAP
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCCHHHCCCCCCCCC
YGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINES
CEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEECCCCCCCCEEEECCCCCC
ETMIWHSGSTPDARAELFTLNESGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVD
CEEEEECCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSTSSPWRTIKIFAPDVALFTSISVTLLAVNGLISILIALRRK
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA