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The map label for this gene is accC2 [H]

Identifier: 218903677

GI number: 218903677

Start: 2436473

End: 2437810

Strand: Direct

Name: accC2 [H]

Synonym: BCAH820_2561

Alternate gene names: 218903677

Gene position: 2436473-2437810 (Clockwise)

Preceding gene: 218903676

Following gene: 218903678

Centisome position: 45.95

GC content: 37.52

Gene sequence:

>1338_bases
ATGTTTCAAAAAATATTAATTGCTAATCGCGGGGAAATCGCAGTTCGTATTATGAAAACTTGTCAAAAACTTGGCATTCG
TACTGTTGCTATTTATTCTGAGGCAGATGAAAATGCCTTACATGTAAAAATGGCAAATGAAGCTTACTTAGTGGGTGGGC
CGCGTGTCCAAGAAAGCTATTTAAACCTTGAAAAAATAATTGAAATAGCGAAGAAGACAAATGCCGAAGCAATCCATCCG
GGATATGGATTATTATCTGAGAATCCATCTTTTCCAGTACGTTGTAAAGAAGAAGGAATCGTATTTATCGGTCCATCAGA
AGAAATCATTACGAAGATGGGGAGTAAAATCGAATCACGTATTGCAATGCAAGCTGCAGATGTCCCAGTAGTTCCAGGTA
TTACTACAAATATTGAAACTGCTGAAGAAGCGATTGAAATTGCGAAACAAATTGGTTATCCATTAATGTTGAAGGCATCC
GCAGGAGGCGGAGGCATTGGAATGCAGTTGATGGAAACTGAGCAAACGCTCACCAAAGCATTTGAAAGCAACAAAACAAG
AGCACAAAACTTCTTCGGTAACGGAGAAATGTATTTAGAGCGCTATATAGCAGACGCGCATCATATTGAAATTCAGCTTT
TAGCAGATACACATGGTAACACAGTGTATTTATGGGAGCGTGAATGTTCAGTACAACGCCGAAATCAGAAAGTGATTGAA
GAAGCACCTTCACCATTTTTAGATGAAGATACACGAAAAGCGATGGGTGAAGTTGCTGTACAAGCTGCTAAAGCCCTAGG
TTATACAAATGCTGGTACAGTTGAGTTTCTTGTAGATGAGCAGAAGAACTTCTATTTCTTAGAGATGAATACGAGATTAC
AAGTAGAGCATCCAGTGACAGAAGAAATTACGGGTTTAGATCTTGTAGAACAACAACTTTTAATTGCATATGGTGAGAAA
TTATCGTTTACACAAGATGATATAAAACGTAGTGGTCATGCCATTGAGGCACGTATTTATGCAGAAGATCCGAAAACTTT
CTTCCCATCACCTGGGAAAATTACAGATTTAACGCTTCCAACAAACGTACGTATTGATCACTTTTTGGAGAATCAAGTAA
CGATTACACCTTTCTATGATCCAATGATTGCGAAAGTCATTGCTCATGGTGAGACTCGTGAAGAAGCAATTTCAAAATTA
CATGATGCTTTAGAAGAATTAAAAGTAGAAGGTATTAAAACAAACACGTCAATGCTACTGCAAGTATTGGAAGATGATGT
GTTCAAAAGTGGTATTTATACAACGGGTTTTGTAACGAAACAACTTGTTAAAAAATAA

Upstream 100 bases:

>100_bases
TCGTGATGCAAAACTATTAGAAATTGGTGAAGGAACTTCTGAAATTCAACGTCTCGTAATTGCTAGACATTTAGGATGTA
GATAAAAAGGAGGAATCACT

Downstream 100 bases:

>100_bases
GATTTAAAAATACTAAGGGGGAAAAAATGATGACGAAAGTATATGCATCGATGGCAGGAAATGTATGGAAGATTGTTGTA
GGAGTAGGAGATACAGTAGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTSMLLQVLEDDVFKSGIYTTGFVTKQLVKK

Sequences:

>Translated_445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTSMLLQVLEDDVFKSGIYTTGFVTKQLVKK
>Mature_445_residues
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHP
GYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKAS
AGGGGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
EAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDEQKNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEK
LSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLPTNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKL
HDALEELKVEGIKTNTSMLLQVLEDDVFKSGIYTTGFVTKQLVKK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=50.7865168539326, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=50.7865168539326, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=50.4504504504504, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=49.2170022371365, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=44.3693693693694, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=44.3693693693694, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=44.3693693693694, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=32.2834645669291, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=32.2834645669291, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=32.2834645669291, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=32.2834645669291, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=32.2834645669291, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=32.9411764705882, Blast_Score=258, Evalue=7e-69,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=46.5168539325843, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.8325791855204, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71987519, Length=438, Percent_Identity=47.945205479452, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=45.413870246085, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=31.9105691056911, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.1369863013699, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.1369863013699, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=47.9545454545455, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319695, Length=453, Percent_Identity=44.5916114790287, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=456, Percent_Identity=44.7368421052632, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.1705426356589, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6323863, Length=459, Percent_Identity=33.1154684095861, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=47.7477477477478, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=44.8198198198198, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=46.5686274509804, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=32.064128256513, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=32.064128256513, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=32.064128256513, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=32.064128256513, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49691; Mature: 49691

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCHHHHH
LNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESR
HCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
IAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGGGGIGMQLMETEQTLTKA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHH
FESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
HHCCCHHHHHCCCCCHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHH
EAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDEQKNFYFLEMNTRLQVEHPVT
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLLIAYGEKLSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLP
HHHCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
TNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKLHDALEELKVEGIKTNTSMLL
CCCEEHEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVLEDDVFKSGIYTTGFVTKQLVKK
HHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMANEAYLVGGPRVQESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCHHHHH
LNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIGPSEEIITKMGSKIESR
HCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHH
IAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGGGGIGMQLMETEQTLTKA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHH
FESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTVYLWERECSVQRRNQKVIE
HHCCCHHHHHCCCCCHHHHHHHHCCCEEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHH
EAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDEQKNFYFLEMNTRLQVEHPVT
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEITGLDLVEQQLLIAYGEKLSFTQDDIKRSGHAIEARIYAEDPKTFFPSPGKITDLTLP
HHHCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECC
TNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISKLHDALEELKVEGIKTNTSMLL
CCCEEHEECCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVLEDDVFKSGIYTTGFVTKQLVKK
HHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]