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The map label for this gene is pepD [H]

Identifier: 218903630

GI number: 218903630

Start: 2384283

End: 2385752

Strand: Direct

Name: pepD [H]

Synonym: BCAH820_2514

Alternate gene names: 218903630

Gene position: 2384283-2385752 (Clockwise)

Preceding gene: 218903629

Following gene: 218903632

Centisome position: 44.96

GC content: 33.47

Gene sequence:

>1470_bases
ATGTATTCTACTTTAGAACAATTAACAAAGCACCCTGTATTTTATCATTTTGCAGAAATTTCAAAGATTCCTAGAGGATC
AGGTAATGAAAAAGAAATTAGTGATTTTTTAGTTGGCTTTGCGAAAGAGCGTAATTTAGAAGTGATTCAAGATGAAGCAT
TAAATGTCATTATTAAAAAAGAAGCAACTGCTGGTTATGAAAATGTACCAGCTATTATTATTCAAGGTCATATGGATATG
GTTTGCGAAAAAAATCAAGCAACCGTACATGATTTTGATAAAGATCCAATTGAATTACGAATTATTGGGGACATGTTATA
TGCAAATCAAACGACTTTAGGAGCTGATAATGGTATTGCAGTTGCATATGCATTAGCTTTATTAGATTCAAAAGACATTC
CGCATCCAGCACTAGAAGTAGTTATTACTACTGAAGAAGAAACGACAATGGGCGGAGCTTTCGCTGTTGATTCAAATCAT
TTTGAAGGAAAGATTTTTATTAATATTGATTCTGAAGAAGATCATAAATTACTTGTAAGTAGCGCAGGTGGTGCAAAAGC
TGTTGAAACGATTCCAGTAATTTGGGATGAAGCACCAGCGAATATGGATGCATACCGTTTATATGTTGGCGGTCTAAAAG
GCGGACATTCTGGTATGGAAATTGATAAACAACGTGGTAATGCGAACAAAGTATTAGGACGAGTATTACATGATTTATCA
GTAAATATTCAATTTGATATAAGTGAAGTTCACGGTGGATTAAAAACGAATGCAATTCCGCGTGAAAGTGTAGCTACAAT
TTTATTATGTCAAGAAGATGTAGAGAAGGTAGAAGAAAAGTTAGAATCATGGACACGAGTATTACAAGAAGAAATGCGTG
CTGTTGATCCAGATGTTCATGTTACACTTACAAAATTAGATGAGAAAGTAGAAAAAGTATTTGCTAAAGAAACACAAAAG
CAACTTATTTCATCATTATTCTTAATTCCGAACGGCATTCAAAGTATGAGCATGGATATTAAAGGTCTAGTAGAAAGCTC
AACAAATTTAGGTGTTATTGAAACGTTGCAAGATGAAATTAAATTACGTAACGAAGTGAGAAGCTCTGTAAGTAGTTTAA
AACAACATATTGCAGATGAGATTAAATGTATTGCGGAATTAGTTGGCGCAACATTTGAAATCGAGTCAGAGTATCCAGAA
TGGCCATACAATCCGAATTCACAAATTCGTAATTTATTTGAAAAAGTGCATCAAGAAAAATACAATAAAGATGTTGAAAT
CTTCGCTGTACACGCTGGGATTGAATGTAGTGTATTTGTTCAAAAGATGCCTGAATTAGATGCAATTTCATTCGGTCCAG
ATATATTCAATGTCCATACTCCAGATGAACATATTAGTATTTCTTCTGTTGTGAATAACTGGGGATTCTTCGTTGATGTA
ATGAAAGGTACGAAAGAATTAGCTAAATAA

Upstream 100 bases:

>100_bases
AGCAGATATTAAAGCATGAAATAGAAAGTGAAAATAATGAATCATGGTATAATGATAAAAGACTTACATATTATTTTGTC
ATTTTGAGAGGAGCTTAAAA

Downstream 100 bases:

>100_bases
TATTCATAAAATGAAGAGTAGCCTATAAAATTTTATAGGCTACTTTTTTGTATAGAGTTTTACTAGAAATTTATTTTTGC
GTTAGTATTTAATTTTGGGT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FEGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLCQEDVEKVEEKLESWTRVLQEEMRAVDPDVHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK

Sequences:

>Translated_489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FEGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLCQEDVEKVEEKLESWTRVLQEEMRAVDPDVHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK
>Mature_489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FEGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLCQEDVEKVEEKLESWTRVLQEEMRAVDPDVHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=36.4583333333333, Blast_Score=333, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 54448; Mature: 54448

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKK
CCCHHHHHHCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCHHEEEEEE
EATAGYENVPAIIIQGHMDMVCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIA
CCCCCCCCCCEEEEECCHHHEECCCCCEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCHH
VAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNHFEGKIFINIDSEEDHKLLVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEE
SAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEHHCCCCHHHHHHHHHHHCE
VNIQFDISEVHGGLKTNAIPRESVATILLCQEDVEKVEEKLESWTRVLQEEMRAVDPDVH
EEEEEEHHHHCCCCCCCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VTLTKLDEKVEKVFAKETQKQLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPEWPYNPNSQIRNLFEKVHQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
CCCCEEEEEEECCCEEEHHHHHCCCCCCEECCCCEEECCCCCHHEEHHHHHHCCHHHHHH
MKGTKELAK
HHHHHHHCC
>Mature Secondary Structure
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKK
CCCHHHHHHCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCHHEEEEEE
EATAGYENVPAIIIQGHMDMVCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIA
CCCCCCCCCCEEEEECCHHHEECCCCCEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCHH
VAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNHFEGKIFINIDSEEDHKLLVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEE
SAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEHHCCCCHHHHHHHHHHHCE
VNIQFDISEVHGGLKTNAIPRESVATILLCQEDVEKVEEKLESWTRVLQEEMRAVDPDVH
EEEEEEHHHHCCCCCCCCCCHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VTLTKLDEKVEKVFAKETQKQLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEI
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPEWPYNPNSQIRNLFEKVHQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
CCCCEEEEEEECCCEEEHHHHHCCCCCCEECCCCEEECCCCCHHEEHHHHHHCCHHHHHH
MKGTKELAK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]