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The map label for this gene is fadE [H]

Identifier: 218903487

GI number: 218903487

Start: 2250051

End: 2251760

Strand: Direct

Name: fadE [H]

Synonym: BCAH820_2371

Alternate gene names: 218903487

Gene position: 2250051-2251760 (Clockwise)

Preceding gene: 218903485

Following gene: 218903488

Centisome position: 42.43

GC content: 35.67

Gene sequence:

>1710_bases
ATGGAGAAAACGAAGTTACCGTGGGATGAATTTTTTTCACTTAATAAAGATGTGAAGCATGCTTTCTTTACGCCAGAAGA
TTTTTCAAGAGATGAAGATTTAATCGCAAAAACGACAGAACAATTCGTTAAACAAGAAATTGTTCCACAAATGGAGAATA
TTGAACAACATAACTATAAAGTTTCCCGTCAATTGTTTGAGAAAGCTGGAGAACTTGGATTATTAAGTATCGAGGTCCCA
GAAGAATATGGCGGATTCGAATTAGGAAAGGCAGTTTCAGGGCTTGTAGCAGAAAAAATGGGATACGCTGGTGCATTTAG
CGTTTCATTTAATATACACGCTGGTGTAGGTACATTGCCTTACATATATTACGGAACGAAAGAACAAAAAGAAAAATATT
TGCCGAAAATTGCGTCTGGAGAATGGATTGGAGCTTATGCTTTAACTGAGCCAAATGCCGGTTCTGATGCATTAAGCGCA
AAAACGAGCGCAGTATTGAATGAAGATGGTACTGCTTGGAAGTTAAATGGTGAGAAGCAGTGGATTACAAATGCTCATAT
GGCAGATGTATACGTTGTTTTTACGAAGACAAATAAAGGAATGACAGCGTTTATTGTCGAAAGAACATGTGAAGGTGTAT
CCATTGGACTAGAAGAAAAGAAAATGGGGATTAAAGGTTCTTCAACGGCTACGCTTATTTTAGAAGATGTTGTTATACCT
GCTGAAAATGTTTTAGGGGAAGTTGGGAAAGGGCATCACGTAGCTCTTAATATTCTTAACTTCGCTAGACTAAAGCTTGC
TTTTGGAAATATTGGAACTGCAAAACAAGCAATTGGATTGTCGGTTCAATATGGAAAAGAGCGAAAACAGTTCCAAACGG
AATTAGTAGATTTTACGATGATTCAAGAGAAAATTGCAAATATGATCATTGCTACATATGGAGCAGAAAGTGCAGCTTAT
CGTACAGCAGGTGTAATTGATGAAGCAATTCATGAGAGTGATGAGGATCTTATGAAGAAAATGTCTCAATTTGCTATTGA
ATGTGCACTGAATAAAGTAAATGCTTCTGAAACACTTGGTCATATCGTAGATGAAGCTGTACAAATTCATGGTGGTTACG
GTTATATGCAAGAATACGAGGTAGAACGATTATATCGTGATGCTAGAATTAGTCGTATTTTTGAAGGAACGAATGAAATT
AATAGATTAACAGTTGCCAAAATGTTAATGAAGCAAATGGAACAAATTGAAGATACTGAAGTAGAGATTGATGTAGCAAA
TGTCGAACGAAATCATCGTTACATTTTATTAGCGAAAAAATTGTTGAAACAATCTTTGAAAACGCTCTCTAAAACTCCAG
GGTTAAAAATTGATCAAGAGCAAGAATATTCACGTGTATTATCTAATATGTTAACGGATGTGTACGTCATGGAATCAGCA
TTTTTACGTACGAGTAAAGCAATTAGTAAAAATGGTGAAGGGAAAGAACGTACGAAACAAATGATAACTGACGTTATTTG
TGAAGAAGGCTATCGTAAAGTAGAAGAAGCGGCGATTTCTATACTTTCAGCGGCTGTTACAGAAGAACAAGATAGGCACG
TAATTTTAGCTGAAATTCGTCAATTATTAGTACCTTTATACACGAACGTATTTACAAAAAAGAGAGAAATTGCGAAAGCT
ATTATAAATCGCGGAAAGTATATTGTGTAA

Upstream 100 bases:

>100_bases
TGAAAAATCATCGCCTTCTGTTTTCAAAAATAAGATATTCCACTCATCGTAGACGTGCATAATTAGTAGCAAGTAAGGCC
GAAATGATAGGGGGATTCAG

Downstream 100 bases:

>100_bases
ATAGGGGGAAAGCGATATGAAAAAGATTGGTTTTATCGGTTTAGGTAACATGGGTCTTCCGATGTCTAAAAATTTAGTTA
AATCAAATTACACAGTATAT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSRDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFTKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Sequences:

>Translated_569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSRDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFTKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV
>Mature_569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSRDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFTKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=550, Percent_Identity=34.9090909090909, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI4557235, Length=583, Percent_Identity=32.2469982847341, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI76496475, Length=583, Percent_Identity=32.2469982847341, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI4557233, Length=402, Percent_Identity=36.5671641791045, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI226958412, Length=401, Percent_Identity=33.9152119700748, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI226958414, Length=377, Percent_Identity=34.7480106100796, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=33.3333333333333, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4501859, Length=394, Percent_Identity=31.7258883248731, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI187960098, Length=391, Percent_Identity=34.0153452685422, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557231, Length=391, Percent_Identity=34.0153452685422, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=29.9212598425197, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4503943, Length=402, Percent_Identity=30.0995024875622, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=30.8510638297872, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI48976061, Length=421, Percent_Identity=25.41567695962, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI211971008, Length=421, Percent_Identity=25.41567695962, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI38505218, Length=400, Percent_Identity=24.25, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=27.8820375335121, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081958, Length=394, Percent_Identity=26.9035532994924, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082384, Length=319, Percent_Identity=26.3322884012539, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081702, Length=378, Percent_Identity=24.0740740740741, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=40.4494382022472, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=32.5641025641026, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=399, Percent_Identity=33.0827067669173, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=398, Percent_Identity=31.4070351758794, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=395, Percent_Identity=32.6582278481013, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17533517, Length=390, Percent_Identity=30, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=282, Percent_Identity=40.0709219858156, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=31.5104166666667, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17570075, Length=416, Percent_Identity=30.2884615384615, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17534353, Length=399, Percent_Identity=27.5689223057644, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=33.9350180505415, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=36.9747899159664, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=393, Percent_Identity=26.2086513994911, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=32.0557491289199, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=25.6, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=27.2, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=522, Percent_Identity=24.7126436781609, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=299, Percent_Identity=24.4147157190635, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=299, Percent_Identity=24.4147157190635, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=370, Percent_Identity=27.2972972972973, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321233, Length=360, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=42.0749279538905, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI21356377, Length=395, Percent_Identity=34.6835443037975, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI21355753, Length=412, Percent_Identity=33.495145631068, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24660351, Length=402, Percent_Identity=32.8358208955224, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24646207, Length=395, Percent_Identity=32.6582278481013, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24666513, Length=393, Percent_Identity=31.8066157760814, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19920834, Length=358, Percent_Identity=30.4469273743017, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24652780, Length=320, Percent_Identity=25, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 63775; Mature: 63775

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSRDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFTKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
EECCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEHHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSRDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFTKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
EECCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEHHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]