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The map label for this gene is ykoH [H]

Identifier: 218903357

GI number: 218903357

Start: 2130959

End: 2132317

Strand: Direct

Name: ykoH [H]

Synonym: BCAH820_2241

Alternate gene names: 218903357

Gene position: 2130959-2132317 (Clockwise)

Preceding gene: 218903356

Following gene: 218903358

Centisome position: 40.19

GC content: 30.71

Gene sequence:

>1359_bases
ATGAAAATTAAAAATAAAATATATTTATTCTCTACAGTATGGTTACTACTTATTTTATTAATTATTAATAGTTCAATATA
TTTTTTGTTTTATAAAGTGACTACGAACGGAGAGTTAGAACGATTGAAACGTGAGGCAATACATATCATTGATGGAATGA
ACGCGGATTCAGCAAAGAAAGTAGATGCAATAAGTCTATTGCAACCATACTTACCTTCAAATGGTATGATTAGAATTATT
AATGAAAATTCAAAGGTAATGATTAGGCAAGAAGTGGATAGTACAAAACCAATTCCAGCATTAAATACGAAATTTGAAAG
AAAAGAGTCAGCTGGAATTTATGAGAAGAACGAGGGTAAATTTGCCTATATAAAAATACCAATCATTTGGAATGATGGGA
AAATCGTTTCGTTAGAAATGACAGAACGTTTAGATAGTTTGCAAGAGAATTTAAATATGTTAAAAAATGTATTAGTTATT
GCATCACTTCTCGTTTTAATTCCGTCTTTTTTTGCAGGAAGAATGTTWAGTAAGCTTATTTTAAAACCTGTAAATTCTTT
AATACAAACTATGGAGCATATACAAGTTAGAGGGATATTCAAAAAAATACCGCTTGAGAACAAGTCAAAAGATGAACTGC
ACAAAATGGGATCGACATTTAATAAAATGATTGATTTATTACATCAGAACTTTGAAAAGCAGCAACAGTTCGTTTCAGAT
GCTTCGCATGAATTAAGAACACCGTTAACAGTTATTGAAAGTTATGCGAAATTATTAAAAAGATGGGGAATGAAAAAACA
AGATGTTTTGGAAGAATCTGTAGAAGCGATTTATTCAGAGGCAGTAAGAATGAAAGGTATGACGAATCAAATGTTGCTTC
TTGCAAATAGTAGTGCTGAGTGGAGTTTGGAGACTAACGAATCAGATTTAGTCCGATTATGTCAGGTGACTGCTGAGCAG
TTAGAAAAAACATATGCTCGGAATTTTCGTGTTATAACAGATGAAGAAAAAATTGTTGTAAATATTGACGAACAAAAAAT
AAAACAAGTATTAGTAGTTTTATTAGATAATGCAATGAAATACAGTAAAGATTCTATAGATATTATAGTAGGAATACAAA
AAGAAAAAGTCTTTTTTTCTATTCAAGATTACGGTATGGGAATTCCTAAAGAAGATATACAGAAAGTATTTGACCGTTTC
TTTCGAGTTGATAAAGCGAGGAGTAGGGAAACAGGGGGGACTGGTTTAGGTTTATCGATTGCCAAACAAATTATTGATGC
TCATGAAGGAGATATACAACTTGAAAGTGAAGAAGGAAAATGGACGAAAGTTACAGTAAATTTACCTTATTTTTCATAA

Upstream 100 bases:

>100_bases
CGTATATATTCGATATTTGCGCAAAAAAGTAGATTGTAATGTGGACGTACCACTTATTCACACTGTTAGAGGTGTTGGGT
ATGTCTTAAAGGTGTAACAT

Downstream 100 bases:

>100_bases
AGAGATAGGAGCTTTAAACATGAAAAAGAAATGGAAAATTGCATTGTTAGTTTGCTTCACGGTTGTAAGTGTAGCGTTTG
TATCACAACGTATTGTTTCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKIKNKIYLFSTVWLLLILLIINSSIYFLFYKVTTNGELERLKREAIHIIDGMNADSAKKVDAISLLQPYLPSNGMIRII
NENSKVMIRQEVDSTKPIPALNTKFERKESAGIYEKNEGKFAYIKIPIIWNDGKIVSLEMTERLDSLQENLNMLKNVLVI
ASLLVLIPSFFAGRMXSKLILKPVNSLIQTMEHIQVRGIFKKIPLENKSKDELHKMGSTFNKMIDLLHQNFEKQQQFVSD
ASHELRTPLTVIESYAKLLKRWGMKKQDVLEESVEAIYSEAVRMKGMTNQMLLLANSSAEWSLETNESDLVRLCQVTAEQ
LEKTYARNFRVITDEEKIVVNIDEQKIKQVLVVLLDNAMKYSKDSIDIIVGIQKEKVFFSIQDYGMGIPKEDIQKVFDRF
FRVDKARSRETGGTGLGLSIAKQIIDAHEGDIQLESEEGKWTKVTVNLPYFS

Sequences:

>Translated_452_residues
MKIKNKIYLFSTVWLLLILLIINSSIYFLFYKVTTNGELERLKREAIHIIDGMNADSAKKVDAISLLQPYLPSNGMIRII
NENSKVMIRQEVDSTKPIPALNTKFERKESAGIYEKNEGKFAYIKIPIIWNDGKIVSLEMTERLDSLQENLNMLKNVLVI
ASLLVLIPSFFAGRMXSKLILKPVNSLIQTMEHIQVRGIFKKIPLENKSKDELHKMGSTFNKMIDLLHQNFEKQQQFVSD
ASHELRTPLTVIESYAKLLKRWGMKKQDVLEESVEAIYSEAVRMKGMTNQMLLLANSSAEWSLETNESDLVRLCQVTAEQ
LEKTYARNFRVITDEEKIVVNIDEQKIKQVLVVLLDNAMKYSKDSIDIIVGIQKEKVFFSIQDYGMGIPKEDIQKVFDRF
FRVDKARSRETGGTGLGLSIAKQIIDAHEGDIQLESEEGKWTKVTVNLPYFS
>Mature_452_residues
MKIKNKIYLFSTVWLLLILLIINSSIYFLFYKVTTNGELERLKREAIHIIDGMNADSAKKVDAISLLQPYLPSNGMIRII
NENSKVMIRQEVDSTKPIPALNTKFERKESAGIYEKNEGKFAYIKIPIIWNDGKIVSLEMTERLDSLQENLNMLKNVLVI
ASLLVLIPSFFAGRMXSKLILKPVNSLIQTMEHIQVRGIFKKIPLENKSKDELHKMGSTFNKMIDLLHQNFEKQQQFVSD
ASHELRTPLTVIESYAKLLKRWGMKKQDVLEESVEAIYSEAVRMKGMTNQMLLLANSSAEWSLETNESDLVRLCQVTAEQ
LEKTYARNFRVITDEEKIVVNIDEQKIKQVLVVLLDNAMKYSKDSIDIIVGIQKEKVFFSIQDYGMGIPKEDIQKVFDRF
FRVDKARSRETGGTGLGLSIAKQIIDAHEGDIQLESEEGKWTKVTVNLPYFS

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=329, Percent_Identity=28.5714285714286, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=28.158844765343, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=27.6363636363636, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786783, Length=333, Percent_Identity=28.2282282282282, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=28, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=242, Percent_Identity=25.2066115702479, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=26.0330578512397, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=27.4678111587983, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=252, Percent_Identity=24.6031746031746, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=274, Percent_Identity=25.1824817518248, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=27.6018099547511, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786912, Length=210, Percent_Identity=27.6190476190476, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=23.469387755102, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=351, Percent_Identity=23.0769230769231, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789403, Length=466, Percent_Identity=22.5321888412017, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=23.1481481481481, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51808; Mature: 51808

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKNKIYLFSTVWLLLILLIINSSIYFLFYKVTTNGELERLKREAIHIIDGMNADSAKK
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHH
VDAISLLQPYLPSNGMIRIINENSKVMIRQEVDSTKPIPALNTKFERKESAGIYEKNEGK
HHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEECCCCC
FAYIKIPIIWNDGKIVSLEMTERLDSLQENLNMLKNVLVIASLLVLIPSFFAGRMXSKLI
EEEEEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKPVNSLIQTMEHIQVRGIFKKIPLENKSKDELHKMGSTFNKMIDLLHQNFEKQQQFVSD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELRTPLTVIESYAKLLKRWGMKKQDVLEESVEAIYSEAVRMKGMTNQMLLLANSSAE
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
WSLETNESDLVRLCQVTAEQLEKTYARNFRVITDEEKIVVNIDEQKIKQVLVVLLDNAMK
EEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
YSKDSIDIIVGIQKEKVFFSIQDYGMGIPKEDIQKVFDRFFRVDKARSRETGGTGLGLSI
CCCCCEEEEEEEECCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AKQIIDAHEGDIQLESEEGKWTKVTVNLPYFS
HHHHHHCCCCCEEEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MKIKNKIYLFSTVWLLLILLIINSSIYFLFYKVTTNGELERLKREAIHIIDGMNADSAKK
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHH
VDAISLLQPYLPSNGMIRIINENSKVMIRQEVDSTKPIPALNTKFERKESAGIYEKNEGK
HHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEECCCCC
FAYIKIPIIWNDGKIVSLEMTERLDSLQENLNMLKNVLVIASLLVLIPSFFAGRMXSKLI
EEEEEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKPVNSLIQTMEHIQVRGIFKKIPLENKSKDELHKMGSTFNKMIDLLHQNFEKQQQFVSD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELRTPLTVIESYAKLLKRWGMKKQDVLEESVEAIYSEAVRMKGMTNQMLLLANSSAE
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
WSLETNESDLVRLCQVTAEQLEKTYARNFRVITDEEKIVVNIDEQKIKQVLVVLLDNAMK
EEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
YSKDSIDIIVGIQKEKVFFSIQDYGMGIPKEDIQKVFDRFFRVDKARSRETGGTGLGLSI
CCCCCEEEEEEEECCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AKQIIDAHEGDIQLESEEGKWTKVTVNLPYFS
HHHHHHCCCCCEEEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]