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The map label for this gene is phoR [H]

Identifier: 218903110

GI number: 218903110

Start: 1900267

End: 1901028

Strand: Direct

Name: phoR [H]

Synonym: BCAH820_1993

Alternate gene names: 218903110

Gene position: 1900267-1901028 (Clockwise)

Preceding gene: 218903109

Following gene: 218903112

Centisome position: 35.84

GC content: 35.17

Gene sequence:

>762_bases
ATGAAGAGAACATATGATGGGGAAATTGGTGTGCTCGTAAAAAGTATAAACGATATGACAGATGAACTGAATGCGATGGA
GAAGATGCGTCAGGAATTTGTTTCGAATGTTTCTCATGAAATACAGTCACCATTAACTTCTATAAAAGGGTTTGCTAGAG
CACTACAAGATACTAATCTTCCTGAGGAAAAAAGAAAGCATTATCTTACCATTATTGAAACAGAAACGACGAGATTATCT
AAACTAAGTCAAAATTTACTGAAACTCACCCTATTAGAGTCGGAAGAATATACACCAGAAAGAGTTACTTATCGATTAGA
TCAACAGTTAAAGCAAATTGTGTTAAATAGTGAACCGCTTTGGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAA
AAGTGCATATAACTGCTGATCAAGAAAGTATGAGTCAAGTTTGGATTAATTTAATTCATAATAGTATTAAATTTACTCCA
AGTAGCGGTACGATTTCAATCAAGTTAAAAGAATATGAGACATTAGTGGAAGTGCGTATTCGCGATTCGGGAATTGGGAT
ATCCGAAGAACAGAAGCAACATATTTTTGAGCGTTTTTATAAAGCGGACTCTTCACGAACTCGTGCTTATGGAGGAAGTG
GCTTAGGTTTAGCGATTGTGAAAAAAGTACTCGATCTTCATCAGGGGGAAATAAAAGTTGAGAGTGAGGAAGGGAATGGG
ACGGAATTTATTGTTTGTATTCCAAATTATGAAGAGAAATAG

Upstream 100 bases:

>100_bases
ATTGCAGTATTAATGAGACCGAAGCGAGAGGCGATGATTTGGACTATTATTGAACCGATACAAAAAATTGCAAAAGGGGA
CTTCTCGGTAAAAATACGAA

Downstream 100 bases:

>100_bases
TGTTAGGAGGGAATCCTTCTAACACTATTTCTCTTTAAAAATATATTTCCCATTACTGCAGCTATACTGATAAGCTTTTC
CTTCGCTATTCATACGGTAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKRTYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLS
KLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQVWINLIHNSIKFTP
SSGTISIKLKEYETLVEVRIRDSGIGISEEQKQHIFERFYKADSSRTRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNG
TEFIVCIPNYEEK

Sequences:

>Translated_253_residues
MKRTYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLS
KLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQVWINLIHNSIKFTP
SSGTISIKLKEYETLVEVRIRDSGIGISEEQKQHIFERFYKADSSRTRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNG
TEFIVCIPNYEEK
>Mature_253_residues
MKRTYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLS
KLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQESMSQVWINLIHNSIKFTP
SSGTISIKLKEYETLVEVRIRDSGIGISEEQKQHIFERFYKADSSRTRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNG
TEFIVCIPNYEEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=28.9156626506024, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=30, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=32.1428571428571, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=28.9915966386555, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=29.1666666666667, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=27.843137254902, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=27.6679841897233, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=28.5106382978723, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=28.8702928870293, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=31.304347826087, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790346, Length=240, Percent_Identity=27.0833333333333, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=26.6393442622951, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=253, Percent_Identity=25.6916996047431, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789403, Length=237, Percent_Identity=27.0042194092827, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=22.8215767634855, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=241, Percent_Identity=25.3112033195021, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=232, Percent_Identity=27.1551724137931, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=25.531914893617, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 29048; Mature: 29048

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPL
CHHHHCCEEEEEECCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
WAEKEIELDLDLEKVHITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRI
CCCCCEEEEECEEEEEEECCHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHEEEEEEE
RDSGIGISEEQKQHIFERFYKADSSRTRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
TEFIVCIPNYEEK
CEEEEECCCCCCC
>Mature Secondary Structure
MKRTYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPL
CHHHHCCEEEEEECCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
WAEKEIELDLDLEKVHITADQESMSQVWINLIHNSIKFTPSSGTISIKLKEYETLVEVRI
CCCCCEEEEECEEEEEEECCHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHEEEEEEE
RDSGIGISEEQKQHIFERFYKADSSRTRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCC
TEFIVCIPNYEEK
CEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]