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The map label for this gene is panE1 [H]

Identifier: 218903035

GI number: 218903035

Start: 1823039

End: 1823983

Strand: Direct

Name: panE1 [H]

Synonym: BCAH820_1918

Alternate gene names: 218903035

Gene position: 1823039-1823983 (Clockwise)

Preceding gene: 218903033

Following gene: 218903038

Centisome position: 34.38

GC content: 35.87

Gene sequence:

>945_bases
ATGCGGATTTTAGTATTAGGAGCTGGTGGCGTTGGAGGCTTTTTTGGAGGTCGCTTAGTAGAAAAAGGAGAAGATGTTAC
GTTTCTTGTTCGTAGTAAACGGAAAAAACAATTGGAGGAAAGGGGACTTGTAATCCGAAGTGTTAACGGAGATTTTTCCT
TTCAACCGAAATTAATAACGAAAGAAGATCGAACTGCTCCATTTGATGTCATTTTATTTTCAACAAAAGCGTATCACTTA
AACGAGGCAATTCAAGATTTGAAACCGTTTGTTGGCGAAAGTACTGTAATCATTCCGTTGTTAAATGGTATTGCTCATTT
ATCGCTATTACAAAAGGAATTCGGTGAGGAAAAAGTAATTGGCGGTTTATGCTTTATCGAGACGACGTTAAACGATGAAG
GAGAAATTGTACAAACTAGCGCTGCAAATAGACTTGTGTTTGGAGAAATGAAGTCTCAACATGCAGAGAAAATAAAGCAT
ATTTCTAAAGCATTTGCAGGTACAAAATCTAGTTTTGTTTTAAGTGAAAATATTACGCAAGATATGTGGCATAAATATTT
ATTTATTACTGTAATGTCAGGTGTGACAACATTAATGCGTGCACCAATAGGACCAATCCGTGAAAGCGAAGGTGGACACG
ATTTTATCCGAAACTTATTTGAAGAATGTGTGCAAATTATGAGATGTATTGGGGCACCCGTTAAAGATGATATTACCGAG
GAACATATGAAAACAATTGATAAAATTTCATATGATATGAAGTCATCGATGCAGCGTGATATGGAAAAAGGCTCGTCCAT
TGAAGGGACGCACTTACAAGGATACTTGCTAGATGTAGCAAAACAATTCTCTATAGAAGCACCATTATTAGGAGTAGTAT
ATCAAAATTTGAAAGTGTATGAAGAAATGAACTTGAACAGATCTGTAATAGAATTGGATGTATGA

Upstream 100 bases:

>100_bases
CTTGGATAAGAATGAAAATTCAGCGTATTTAGTAGGGGACATGTATAATGTTATGTATACTAAAAGTTATAAATTTATAT
TTTGAAAAGGGGGATGTTGT

Downstream 100 bases:

>100_bases
AAAAATAAAAAAGAAAGCAATATATAAGTGTATTGCTTTCTTTTTTATGACAAATTATTTATTTCTTTTTGTTCTATCTG
TCAAATTTATTTCCTGTTCA

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDRTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHLSLLQKEFGEEKVIGGLCFIETTLNDEGEIVQTSAANRLVFGEMKSQHAEKIKH
ISKAFAGTKSSFVLSENITQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGHDFIRNLFEECVQIMRCIGAPVKDDITE
EHMKTIDKISYDMKSSMQRDMEKGSSIEGTHLQGYLLDVAKQFSIEAPLLGVVYQNLKVYEEMNLNRSVIELDV

Sequences:

>Translated_314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDRTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHLSLLQKEFGEEKVIGGLCFIETTLNDEGEIVQTSAANRLVFGEMKSQHAEKIKH
ISKAFAGTKSSFVLSENITQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGHDFIRNLFEECVQIMRCIGAPVKDDITE
EHMKTIDKISYDMKSSMQRDMEKGSSIEGTHLQGYLLDVAKQFSIEAPLLGVVYQNLKVYEEMNLNRSVIELDV
>Mature_314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDRTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHLSLLQKEFGEEKVIGGLCFIETTLNDEGEIVQTSAANRLVFGEMKSQHAEKIKH
ISKAFAGTKSSFVLSENITQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGHDFIRNLFEECVQIMRCIGAPVKDDITE
EHMKTIDKISYDMKSSMQRDMEKGSSIEGTHLQGYLLDVAKQFSIEAPLLGVVYQNLKVYEEMNLNRSVIELDV

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 35165; Mature: 35165

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLIT
CEEEEEECCCCCHHHCCHHHHCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCEECCCEEC
KEDRTAPFDVILFSTKAYHLNEAIQDLKPFVGESTVIIPLLNGIAHLSLLQKEFGEEKVI
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHHC
GGLCFIETTLNDEGEIVQTSAANRLVFGEMKSQHAEKIKHISKAFAGTKSSFVLSENITQ
CEEEEEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHH
DMWHKYLFITVMSGVTTLMRAPIGPIRESEGGHDFIRNLFEECVQIMRCIGAPVKDDITE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EHMKTIDKISYDMKSSMQRDMEKGSSIEGTHLQGYLLDVAKQFSIEAPLLGVVYQNLKVY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EEMNLNRSVIELDV
HHCCCCCCEEEECC
>Mature Secondary Structure
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLIT
CEEEEEECCCCCHHHCCHHHHCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCEECCCEEC
KEDRTAPFDVILFSTKAYHLNEAIQDLKPFVGESTVIIPLLNGIAHLSLLQKEFGEEKVI
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCHHHC
GGLCFIETTLNDEGEIVQTSAANRLVFGEMKSQHAEKIKHISKAFAGTKSSFVLSENITQ
CEEEEEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHH
DMWHKYLFITVMSGVTTLMRAPIGPIRESEGGHDFIRNLFEECVQIMRCIGAPVKDDITE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EHMKTIDKISYDMKSSMQRDMEKGSSIEGTHLQGYLLDVAKQFSIEAPLLGVVYQNLKVY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EEMNLNRSVIELDV
HHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]