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The map label for this gene is mntH [H]

Identifier: 218903032

GI number: 218903032

Start: 1818416

End: 1819711

Strand: Reverse

Name: mntH [H]

Synonym: BCAH820_1915

Alternate gene names: 218903032

Gene position: 1819711-1818416 (Counterclockwise)

Preceding gene: 218903034

Following gene: 218903028

Centisome position: 34.32

GC content: 37.58

Gene sequence:

>1296_bases
ATGAATAAAGATATATCAAAAGATGAACATGTCCCTTCTCAAAGTACAACTGTTCAATCAGCGCATTTAGCATTAAGCGG
ACAAACGAAAGGCTTAAAAAGACTATTACCATTCTTAGGTCCTGCTTTCATCGCTTCAGTCGCTTATATTGATCCTGGCA
ATTTCGCGACAAATATTGCCGCTGGATCACAATATGGATATTTATTACTCTGGGTAATTCTTGCTTCTAATTTAATGGCT
GTATTAATCCAAACTTTATCCGCTAAATTGGGAATCGCTACGGGCAGAAACCTTCCTGAGATCGCTCGAGAAAACTTCCC
AAAATCTGTTTCCATCGGTTTATGGATACAAGGTGAACTCGTTATTATGGCGACTGATTTAGCTGAATTTATTGGAGCCG
CACTCGGATTGTATTTATTATTTGGGATTCCGATGTTACCCGCAGCTTTAATTACAGCTGCTGGATCATTTATTATTCTT
GAATTTCAACGCAGAGGCTTTCGTCCATTAGAAGCGATTATAACGGGGATGATTTTTATCGTTGTTATCGCTTTTGGTGT
ACAAGTCTTTTATGCAAAACCGGAATTAAGTCCTTTACTTTCAGGGCTTTTCATTCCGAAATTCCAAGGTGTAGACAGTA
TATTACTTGCAGCTGGAATTTTAGGTGCGACAGTTATGCCGCACGCAATCTATTTACATTCCGCCTTAACACAACGCCGC
GTAGTCGGAACAAATGATGAACAAAAGAAAAAGATTTTCCGCTTCGAGTTTATTGATATCATTATCGCAATGATTATCGC
TGGAGCAATTAATGCAAGTATGTTAATTGTTGCTGCTGCACTATTCTTTAAAAACGGCTTGCATGTTGAAGATCTTGATG
TTGCTTTTAACCAGTTTAGTAACTTAGTCGGTCCTGTATCAGCTGCTTTATTTGGAATTGGTCTCTTATCAGCAGGACTA
TCTAGCTCTTCTGTCGGTACAATGTCAGGTGATATTATTATGCAAGGTTTCATTCGAATGCACATTCCGTTATACTTACG
CCGATTTATTACAATGATTCCGCCATTAGTTATTATCGCTTTAGGTGTAAATCCAACTTACGCTCTAGTCATGAGCCAAG
TCGTCTTATCATTCGGTATTGCCTTTGCATTAGTACCACTTATTATGTTTACAAGTAGTAAAAAAATTATGGGTACACTC
GTTAATCACCGCATAACTACCTTTATCGCTTGGATTATTGCTGTACTTGTTATCATTTTAAATATTTTCTTACTGTATCA
AACATTTGTGGGTTAA

Upstream 100 bases:

>100_bases
AAATAAAAATATAACATATTACATTTAAATGTATTGAAATAAAGAATAAGAATACTTACAATAATTTCATCAAGTTAACA
TTTCAAAGGGGAAAACTACT

Downstream 100 bases:

>100_bases
TAAAAAGGGTATTCCAATTTCAATTTGGAATACCCTTTTTGTTTGAATTACTTTCCTTCTACTTATCACTCATATATGTC
CCTCTTTCCGGCATCATCGC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNKDISKDEHVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKSVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMIIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGTL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG

Sequences:

>Translated_431_residues
MNKDISKDEHVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKSVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMIIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGTL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG
>Mature_431_residues
MNKDISKDEHVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGRNLPEIARENFPKSVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTNDEQKKKIFRFEFIDIIIAMIIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFSNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGTL
VNHRITTFIAWIIAVLVIILNIFLLYQTFVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=441, Percent_Identity=31.9727891156463, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI295293167, Length=436, Percent_Identity=32.3394495412844, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI295293178, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI295293171, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI295293169, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI295293175, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI295293173, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI10835169, Length=436, Percent_Identity=32.3394495412844, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=50.75, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI193210616, Length=465, Percent_Identity=29.8924731182796, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17569473, Length=395, Percent_Identity=33.4177215189873, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71999499, Length=457, Percent_Identity=28.8840262582057, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993856, Length=242, Percent_Identity=33.0578512396694, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321841, Length=437, Percent_Identity=33.8672768878719, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323062, Length=397, Percent_Identity=32.4937027707809, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324450, Length=426, Percent_Identity=32.6291079812207, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24648607, Length=443, Percent_Identity=29.7968397291196, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281362176, Length=443, Percent_Identity=29.7968397291196, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24648609, Length=443, Percent_Identity=29.7968397291196, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45553443, Length=421, Percent_Identity=30.6413301662708, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46484; Mature: 46484

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDISKDEHVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCCCCCCCCCCHHHHHHEEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGRNLPEIARENFPKSVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIILEFQRRGFRPLEAIITGMIFI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHH
VVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVGTNDEQKKKIFRFEFIDIIIAMIIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGTLVNHRITTFIAWIIAVLVIIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC
>Mature Secondary Structure
MNKDISKDEHVPSQSTTVQSAHLALSGQTKGLKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCCCCCCCCCCHHHHHHEEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGRNLPEIARENFPKSVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIILEFQRRGFRPLEAIITGMIFI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHH
VVIAFGVQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVGTNDEQKKKIFRFEFIDIIIAMIIAGAINASMLIVAAALFFKNGLHVEDLDVAFNQFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSSKKIMGTLVNHRITTFIAWIIAVLVIIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146 [H]