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The map label for this gene is ilvD [H]

Identifier: 218903008

GI number: 218903008

Start: 1791192

End: 1792865

Strand: Direct

Name: ilvD [H]

Synonym: BCAH820_1891

Alternate gene names: 218903008

Gene position: 1791192-1792865 (Clockwise)

Preceding gene: 218903007

Following gene: 218903009

Centisome position: 33.78

GC content: 40.98

Gene sequence:

>1674_bases
ATGAGAAGTGACATGATTAAAAAAGGTTTTGATAAAGCGCCGCATCGTAGTTTATTAAAAGCAACTGGTTTGAAAGATGA
AGACTTTGATAAACCGTTTATAGCGATCTGTAACTCTTTTATTGAAATTATTCCAGGTCATAAGCACTTAAATGAGTTTG
GGAAGCTTGTTAAAGAAGCAGTACGTGCAGCAGGTATGGTTCCATTTGAATTTAATACAATTGGAGTAGATGACGGTATT
GCGATGGGGCATATCGGTATGCGCTATTCGCTTCCGAGTCGAGAAATTATTGCAGATTCAGTAGAAACGGTTGTAAATGC
CCATTGGTTTGATGGCATGATTTGCATTCCAAACTGTGACAAAATCACACCCGGTATGATGATGGCTGCACTTCGTATTA
ACATTCCAACTGTTTTTGTTTCAGGTGGTCCGATGGCGGCTGGAAAAACATCTAAAGGAGACGTTGTTGATTTAAGTTCT
GTTTTCGAAGGAGTAGGGGCTTATCAATCTGGGAAAATTTCAGAAGAAGAATTAAAGGATATTGAAGATCATGGCTGTCC
ATCTTGTGGTTCTTGTTCTGGTATGTTTACAGCGAACTCTATGAACTGTTTATGTGAAGTGTTAGGTTTAGCTCTTCCTG
GTAACGGAAGTATTTTGGCTATTGATCCAAGACGCGAAGAATTAATTAAACAAGCAGCAGAAAAATTAAAGATTTTAATT
GAAAGAGATATTAAACCGAGAGACATTGTAACGGAAGAAGCAATTGATGATGCGTTCGCGCTTGATATGGCAATGGGCGG
TTCAACAAATACAGTGTTGCATACATTGGCGCTCGCGCAAGAGGCTGGATTAGATTACGATATGAACCGTATTGATGCCG
TTTCAAGACGTGTACCACATTTATGTAAAGTAAGCCCTGCTTCCAATTGGCATATGGAAGACATTGATCGTGCAGGCGGG
ATTAGTGCAATTTTGAAAGAGATGAGCCGAAAAGAAGGGGTACTTCATTTAGACCGTATTACTGCTACGGGGCAAACATT
AAGAGAAAATATTGCTCATGCAGAGATTAAAGATAAGGAAGTGATTCATTCTCTTGAAAATCCTCATAGTGAAGAAGGTG
GATTACGTATATTAAAAGGAAACCTTGCGAAAGACGGAGCAGTTATTAAAAGCGGGGCAACCGAAGTAATACGATTTGAA
GGGCCTTGTGTTATTTTTAATTCACAAGATGAGGCGCTTGCCGGCATTATGCTTGGGAAGGTTAAGAAAGGAGATGTAGT
TATTATTCGTTATGAAGGACCAAGAGGCGGTCCAGGTATGCCGGAAATGTTAGCACCAACGTCAGCGATTGCTGGCATGG
GATTAGGTGCGGATGTTGCGTTATTAACCGATGGTCGTTTCTCTGGTGCTTCACGTGGTATTTCAGTAGGGCATATTTCG
CCAGAAGCAGCTGCGGGCGGAACGATTGCACTTCTTGAACAAGGGGATATCGTTTGTATCGATGTTGAGGAAAGGTTGTT
AGAAGTGAGAGTTAGTGACGAAGAATTAGATAAGCGTAAAAAAGAATGGAAACGACCAGAACCGAAAGTGAAAACGGGCT
GGCTTGGACGTTATGCACAAATGGTAACATCGGCGAATACAGGTGCAGTCCTAAAAATCCCGAATTTTGATTGA

Upstream 100 bases:

>100_bases
CTTCGTGAAATGATGAGCTGGATTCATGCACCGAAAGAATTAGTGAAGAAATAGAGTAATAGATTGCAAGTGAAAAATAC
GTAAGAGGGGATTTGACAAG

Downstream 100 bases:

>100_bases
GTCAATATAAAAGAGATAAGGATGATATGAAATGGTGCAAAAGGTAAAGGAGAAAGTGAAAATTGAAGATATCTTAATGG
CCCATACTTGTATGAAAGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVIRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVIIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD

Sequences:

>Translated_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVIRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVIIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD
>Mature_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVIRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVIIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKIPNFD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=47.8547854785479, Blast_Score=546, Evalue=1e-157,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=30.5555555555556, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI2367371, Length=525, Percent_Identity=31.4285714285714, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI1786464, Length=489, Percent_Identity=31.0838445807771, Blast_Score=175, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=42.0183486238532, Blast_Score=425, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59992; Mature: 59992

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHHHHHCCHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVIRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEECCCEEEECCCCHHHHHHHHCC
VKKGDVVIIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKIPNFD
HHHCCCCCEEEECCCCC
>Mature Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGDVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHHHHHCCHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVIRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEECCCEEEECCCCHHHHHHHHCC
VKKGDVVIIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKIPNFD
HHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA