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The map label for this gene is msrA1 [H]

Identifier: 218903002

GI number: 218903002

Start: 1784931

End: 1785467

Strand: Reverse

Name: msrA1 [H]

Synonym: BCAH820_1885

Alternate gene names: 218903002

Gene position: 1785467-1784931 (Counterclockwise)

Preceding gene: 218903003

Following gene: 218902997

Centisome position: 33.67

GC content: 37.43

Gene sequence:

>537_bases
ATGTCCGAAAAAACATACGAACTCGCAACCTTCGCAGGCGGTTGCTTTTGGTGCATGGTAAAGCCTTTTGATGAACTTCC
CGGTATTCATAAAGTACTTTCCGGCTATGCAGGTGGTCATGTAGAAGACCCAACATATGAACAAGTAAAAGCGGGTACAT
CTGGTCATTTAGAAGTTGTACAAATTACATTTGATCCTTCTATTTTTCCATATGAAAAATTATTAAATTTATATTGGCCA
CAAATCGATCCAACTGATGATGGCGGACAATTCTTTGACCGTGGTCCATCTTATCGCACCGCTATTTTTTATCATACCGA
AACACAAAAAGAGCTTGCTGAAAAATCAAAACATTCTCTTGCAGAAAGCGGTATGTTTAAAGATCCAATTGTAACTGAAA
TTCGCCCGGCTGCACCTTTTTATGAGGCTGAAGAATACCATCAACATTTCTATAAAAAGAACCCAGAGAAATATGCTACT
GAGCAAAAAGAATCTGGCCGTGAAGACTTTATAAAAGAAAATTGGCAAAAAAAATAA

Upstream 100 bases:

>100_bases
CTTGTTTATAAAAAAGCATATATTTTCAAATCTTTTTTATTGCGCAATAAAACAATTTATATAATACTATATAAAACATA
TATTTAGGAGGATTACAGCA

Downstream 100 bases:

>100_bases
TAAAAACGCATCGTGCTCTCTTTTCAAAGTGCGATGCGTTTTTATCTTTGAAAAAAGTACCATACAATGATGAGAACAAC
CGCTGTTAATGTCCAAAGTA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVEDPTYEQVKAGTSGHLEVVQITFDPSIFPYEKLLNLYWP
QIDPTDDGGQFFDRGPSYRTAIFYHTETQKELAEKSKHSLAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYAT
EQKESGREDFIKENWQKK

Sequences:

>Translated_178_residues
MSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVEDPTYEQVKAGTSGHLEVVQITFDPSIFPYEKLLNLYWP
QIDPTDDGGQFFDRGPSYRTAIFYHTETQKELAEKSKHSLAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYAT
EQKESGREDFIKENWQKK
>Mature_177_residues
SEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVEDPTYEQVKAGTSGHLEVVQITFDPSIFPYEKLLNLYWPQ
IDPTDDGGQFFDRGPSYRTAIFYHTETQKELAEKSKHSLAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYATE
QKESGREDFIKENWQKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. May deal with oxidative damage to alpha/beta-type SASP in sp

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=38.8535031847134, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=38.8535031847134, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI208609993, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=41.4473684210526, Blast_Score=123, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.1724137931034, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=32.5153374233129, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=34.5070422535211, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=33.8028169014084, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=33.5766423357664, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20561; Mature: 20430

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVEDPTYEQVKAGTSGHLEVV
CCCCHHHHHHHCCCEEEEEECCHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEE
QITFDPSIFPYEKLLNLYWPQIDPTDDGGQFFDRGPSYRTAIFYHTETQKELAEKSKHSL
EEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
AESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK
HHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
SEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVEDPTYEQVKAGTSGHLEVV
CCCHHHHHHHCCCEEEEEECCHHHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEE
QITFDPSIFPYEKLLNLYWPQIDPTDDGGQFFDRGPSYRTAIFYHTETQKELAEKSKHSL
EEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH
AESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK
HHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9573155 [H]