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The map label for this gene is gltT [H]

Identifier: 218902963

GI number: 218902963

Start: 1740016

End: 1741287

Strand: Direct

Name: gltT [H]

Synonym: BCAH820_1846

Alternate gene names: 218902963

Gene position: 1740016-1741287 (Clockwise)

Preceding gene: 218902961

Following gene: 218902964

Centisome position: 32.81

GC content: 37.26

Gene sequence:

>1272_bases
ATGAAAAAATTCGGATTAGCGACACAAATTTTTGTCGCACTTGTTTTAGGGATTGTAGTAGGGGCAATCTTCTATGGTAA
TAAAACGGCGATTTCTTATATCACACCAATTGGGGATATATTTATTCACTTAATTAAAATGATTGTAGTACCGATTGTTA
TTTCAGCATTAATTGTTGCGGTAGCTGGTGTAGGCGATATGAAGAAGCTTGGGAAACTAGGCGGAAAGACAATTCTTTAT
TTTGAAATCATTACGACGATCGCTATTTTAATGGGATTACTTGCGGCGAATATATTCCAGCCAGGTACTGGCGTTGATAT
GAATAACTTACAGCAAAGTGACATTTCTTCTTATAAACAAACAGCAGATGCTACAGAGAAGCAAGGATTCGCTGAGACGA
TTGTTCATATTGTACCGAAAAACGTATTTGAATCGATTGCACAAGGTGACTTATTACCGATTATTTTCTTCTCAGTATTA
TTCGGTTTAGGAGTTGCAGCAATTGGGGAAAAAGGAAAGCCTGTCTTTAATTTCTTTGAAGGTGTACTCGAAGCGATGTT
TTGGGTTACAAATCAAGTGATGAAATTTGCACCATTTGGTGTATTCGCATTAATTGCGGTTACAGTTGCAAAATTTGGTG
TAGCAACACTACTTCCTTTAGGAAAACTAGTGCTAGCCGTATACGTAACTGTTATACTATTCGTTGTGATTGTATTAGGT
ATTAATGCACGAATGGTTGGCGTAAATATTTTTACATTAATGAAAATTTTAAAAGAAGAACTAATTCTTTCATTTACGAC
AGCAAGTTCAGAAGCTGTTTTACCTAATATAATGAGAAAAATGGAAGAGTTCGGTTGTCCAAAGGCAGTTGCCTCTTTCG
TAATTCCGACAGGTTATACATTTAACTTGACTGGATCAGCTATTTATCAAGCGTTAGCGGCATTGTTTGTTGCACAAATG
TACGGTGTGCACATGTCACTGACAGAGCAAATAACGTTATTATTCGTTCTCATGTTAACATCCAAAGGTATGGCGGGAGT
TCCAGGTGCATCGTTCGTTGTTGTATTAGCAACGTTAGGTTCAATGGGGTTACCACTAGAAGGTATCGCGTTAATTGCGG
GAATTGACCGCATTTTAGATATGATTCGCTCATCTGTCAATGTATTAGGAAATGCATTAGCGGCCATTGTTATGTCGAAG
TGGGAAGGCGAATTCGATAATGAGAAAGCAAAACAATATGTAGAAACAGTCAAAGAAACAAAAGCAGCATAG

Upstream 100 bases:

>100_bases
TGTAGGTTTTTGTATGATTTTGTAGGTTCGCCTATATGATGTGTGAGTAAGCTTTTATAAATACGAAATGAAAGCGTTCG
CATAAAGGGGATGAACATAA

Downstream 100 bases:

>100_bases
GAAATCGTTAAGGAGTGAATAATCATGGCTACATTAACTGAAGTTAAAAATGGTGTTCGAATTGAAAAAGATTTTTTAGG
TGAAAAAGAAGTACCAAACT

Product: proton/sodium-glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVAQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA

Sequences:

>Translated_423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVAQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA
>Mature_423_residues
MKKFGLATQIFVALVLGIVVGAIFYGNKTAISYITPIGDIFIHLIKMIVVPIVISALIVAVAGVGDMKKLGKLGGKTILY
FEIITTIAILMGLLAANIFQPGTGVDMNNLQQSDISSYKQTADATEKQGFAETIVHIVPKNVFESIAQGDLLPIIFFSVL
FGLGVAAIGEKGKPVFNFFEGVLEAMFWVTNQVMKFAPFGVFALIAVTVAKFGVATLLPLGKLVLAVYVTVILFVVIVLG
INARMVGVNIFTLMKILKEELILSFTTASSEAVLPNIMRKMEEFGCPKAVASFVIPTGYTFNLTGSAIYQALAALFVAQM
YGVHMSLTEQITLLFVLMLTSKGMAGVPGASFVVVLATLGSMGLPLEGIALIAGIDRILDMIRSSVNVLGNALAAIVMSK
WEGEFDNEKAKQYVETVKETKAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=469, Percent_Identity=28.7846481876333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40254478, Length=483, Percent_Identity=26.5010351966874, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI21314632, Length=438, Percent_Identity=26.4840182648402, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI194239697, Length=471, Percent_Identity=24.8407643312102, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI66773030, Length=439, Percent_Identity=27.7904328018223, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI4827012, Length=287, Percent_Identity=33.1010452961672, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI262359914, Length=404, Percent_Identity=27.4752475247525, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI5032093, Length=428, Percent_Identity=25.7009345794392, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223468566, Length=273, Percent_Identity=27.8388278388278, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223468564, Length=273, Percent_Identity=27.8388278388278, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI301601644, Length=200, Percent_Identity=31, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=55.0827423167849, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=42.3267326732673, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1788024, Length=400, Percent_Identity=29.5, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789473, Length=340, Percent_Identity=25.8823529411765, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=28.4688995215311, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193206505, Length=451, Percent_Identity=27.4944567627494, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=441, Percent_Identity=27.6643990929705, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=441, Percent_Identity=27.6643990929705, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71996953, Length=487, Percent_Identity=26.8993839835729, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI193206654, Length=426, Percent_Identity=26.7605633802817, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541374, Length=420, Percent_Identity=27.6190476190476, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24583025, Length=441, Percent_Identity=26.7573696145125, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17137668, Length=441, Percent_Identity=26.7573696145125, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583023, Length=441, Percent_Identity=26.7573696145125, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281360481, Length=447, Percent_Identity=25.0559284116331, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI281360483, Length=447, Percent_Identity=25.0559284116331, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17137666, Length=447, Percent_Identity=25.0559284116331, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45256; Mature: 45256

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]