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The map label for this gene is ilvC1 [H]

Identifier: 218902607

GI number: 218902607

Start: 1408238

End: 1409248

Strand: Direct

Name: ilvC1 [H]

Synonym: BCAH820_1490

Alternate gene names: 218902607

Gene position: 1408238-1409248 (Clockwise)

Preceding gene: 218902606

Following gene: 218902608

Centisome position: 26.56

GC content: 40.55

Gene sequence:

>1011_bases
ATGGCAAAAGTTTATTATGAAAAAGATGTAACGGTAAATGTATTAAAGGAAAACAAAGTAGCAATCATTGGATATGGCTC
GCAAGGTCATGCACATGCGCAAAATTTACGTGATAACGGATTTGATGTAGTAGTAGGTTTAAGAAAAGGGAAGTCTTGGG
ATAAAGCGAAAGAAGATGGATTTTCTGTATATACAGTAGCAGAAGCAGCAAAGCAGGCTGATGTAGTAATGATTTTGCTG
CCAGATGAACTGCAACCAGAAGTATATGAAGAGGAAATTGCCCCAAATTTACAGGCAGGAAATTCTCTCGTTTTTGCACA
CGGATTTAATGTTCACTTTGATCAAGTGAAACCACCAGTGAATGTAGATGTATTTCTAGTAGCACCAAAAGGTCCAGGAC
ATCTTGTGCGTCGTACGTTTAGTGAGGGCGGAGCTGTTCCTGCATTATTTGCAGTATATCAAGATGCAACAGGAGTTGCG
ACTGAAAAGGCACTTTCTTATGCTGATGGAATTGGAGCGACGAGAGCTGGTGTATTAGAAACGACATTTAAAGAAGAAAC
GGAAACAGATTTATTTGGAGAGCAAGCTGTACTTTGCGGCGGAGTAACTGCGCTAGTCAAAGCTGGATTTGAAACGTTAG
TTGATGCCGGATATCAGCCGGAACTTGCATATTTTGAATGTTTACATGAACTGAAACTTATTGTTGACCTTATGTATGAA
GGTGGACTTGAAAATATGAGATATTCAGTTTCAGATACAGCGCAGTGGGGCGACTTCGTATCAGGACCACGTGTTGTAAC
GGAAGATACGAAGAAAGCGATGGGTGCAGTGTTAGCAGAAATTCAAGATGGTACATTTGCAAGAGGTTGGATTGCAGAAC
ATAAAGCAGGAAGACCGAATTTCCATGCGACAAATGAGAAAGAAAATGAACATGAAATCGAAGTAGTTGGACGTAAATTA
CGTGAAATGATGCCTTTCGTACAGCCGCGAGTAAAGGCAGGGATCAAATAA

Upstream 100 bases:

>100_bases
TTGCTAGAACAGGGGTAACAGCCTTTACGCGTAGCATGAAAAAGCAAGATAAGCAAGTAATGTTAATTCAATAATCATTT
AAATATAGGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TATGAAGCAAATTTTGTTCATGGATACGACGCTACGTGATGGCGAACAATCACCAGGAGTAAATTTAAATGAACAAGAGA
AATTGCAAATTGCAAGGCAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 1; Alpha-keto-beta-hydroxylacil reductoisomerase 1 [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKVYYEKDVTVNVLKENKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKL
REMMPFVQPRVKAGIK

Sequences:

>Translated_336_residues
MAKVYYEKDVTVNVLKENKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKL
REMMPFVQPRVKAGIK
>Mature_335_residues
AKVYYEKDVTVNVLKENKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLP
DELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVAT
EKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEG
GLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKLR
EMMPFVQPRVKAGIK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.4709897610922, Blast_Score=141, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=34.8348348348348, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36737; Mature: 36606

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYYEKDVTVNVLKENKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CCEEEEECCCEEEEEECCCEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV
CEEEEHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCEEEHHCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEECHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENEHEIEVVGRKLREMMPFVQPRVKAGIK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure 
AKVYYEKDVTVNVLKENKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CEEEEECCCEEEEEECCCEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEEEIAPNLQAGNSLVFAHGFNVHFDQVKPPV
CEEEEHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCEEEEEECCEEEHHCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEECHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENEHEIEVVGRKLREMMPFVQPRVKAGIK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]