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The map label for this gene is cls1 [H]

Identifier: 218901819

GI number: 218901819

Start: 654045

End: 655574

Strand: Reverse

Name: cls1 [H]

Synonym: BCAH820_0680

Alternate gene names: 218901819

Gene position: 655574-654045 (Counterclockwise)

Preceding gene: 218901823

Following gene: 218901818

Centisome position: 12.36

GC content: 35.36

Gene sequence:

>1530_bases
ATGAAGAAACCTATCGTCCAATTACTATTAATATTTACAATTGTATCTATCGTTCTTTTCCTATTAAATACATCTTATAT
TTCGTTATATACATTTGTCGGCGTTCTCTGGTCCATCACAATTGTAGGAATTTCATTCGTTATTTTTATCGAAAATAGAT
CTCCTCAAAGTACCTTAGCCTGGTTTTTAGTATTAGCACTTCTTCCCGTTATAGGTGTGCTTTTATACTCTATTTTCGGG
CGTAGCCGTTGGAGAAGAAAAAAGCATCTCCATCGTTCAGAAGAGCAAAGAAAGTTATTCCGTGAAATATTAGAAGGAAG
ACGACTAGAGTTATCACTCAAAGTCCCATTAAGTGAACGCTCTGTCCATTTAACAGAAGTCGTACAAAAATTTGGAGGCG
GGCCTGCAGCAGATAGAACGACTACCAAACTTTTAACAAACGGAGATCAAACATTCTCAGAAATTTTGCAAGCGATCGAG
CAAGCAAAACATCACATACATATTCAATACTATATTTATAAATCTGATGAGATTGGTACAAAAGTTCGGGATGCGTTAAT
CAAAAAGGCAAAAGATGGTGTTATTGTACGCTTCCTTTATGATGGACTCGGAAGTAATACGTTGAGAAGACGGTTTTTAC
AACCTATGAAAGAAGCTGGAATTGAAATTGTTGAATTTGATCCTATTTTTTCAGCTTGGTTACTTGAAACCGTCAATTAT
CGTAACCACCGTAAAATCGTCATTGTAGATGGAGAAATCGGTTTTACTGGTGGACTCAACGTCGGTGATGAATATCTTGG
TCGTTCAAAAAAATTTCCAGTTTGGCGTGACAGTCATTTAAAAGTAGAAGGAAAAGCGCTATATAAATTACAAGCAATCT
TTCTAGAGGATTGGCTCTATGCATCTAGTGGATTGAATACTTATTCTTGGGATCCATTTATGAATAGACAATACTTCCCT
GGTAAAGAAATTTCAAATGCAGAAGGTGCTGTGCAAATTGTAGCGAGCGGACCAAGCTCAGATGATAAAAGCATTCGCAA
TACATTATTAGCTGTTATGGGCTCGGCAAAAAAATCTATTTGGATTGCTACACCATACTTTATTCCAGATCAAGAAACTT
TAACATTACTACGTTTAAGTGCAATATCTGGCATAGATGTACGCATTTTATATCCTGGTAAAAGTGATAGTATTATTAGT
GACCAAGCATCTCAGTCCTACTTCACTCCACTTTTAAAAGCTGGTGCCTCCATTTATAGTTATAAAGATGGCTTTATGCA
TGCAAAAATTGTACTTGTTGATGATAAAATCGCAACAATCGGAACAGCAAATATGGACGTACGCAGCTTTGAATTGAATT
ACGAAATTATTAGCGTACTGTATGAATCAGAAACTGTTCATGATATTAAACGTGATTTTGAAGATGACTTTAAGCATTCT
ACTGAAATTAAATGGAACGCTTTCCAAAAGAGAAGTATCAAAAAACGAATATTAGAATCTTTTATGAGGCTCATTTCTCC
TTTACTATAA

Upstream 100 bases:

>100_bases
ATTTTGTAAAAAATAGAAAACACTTTATAATAAAAATGTCACAGTACATCTGCTATTTAGGAAATCTATATTGAGGAAAG
ATTAGAGGAATTATATAAAA

Downstream 100 bases:

>100_bases
GCAATCAATGTATTATTGATTGCTTTTTCTTTTATATTTGTCCCCTCTCCTTTTCTTTGCATACCATATTAAAACAAGTT
ATCATAAGATGTATTACTTT

Product: cardiolipin synthetase

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGVLWSITIVGISFVIFIENRSPQSTLAWFLVLALLPVIGVLLYSIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELSLKVPLSERSVHLTEVVQKFGGGPAADRTTTKLLTNGDQTFSEILQAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIKKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKVEGKALYKLQAIFLEDWLYASSGLNTYSWDPFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAISGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDKIATIGTANMDVRSFELNYEIISVLYESETVHDIKRDFEDDFKHS
TEIKWNAFQKRSIKKRILESFMRLISPLL

Sequences:

>Translated_509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGVLWSITIVGISFVIFIENRSPQSTLAWFLVLALLPVIGVLLYSIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELSLKVPLSERSVHLTEVVQKFGGGPAADRTTTKLLTNGDQTFSEILQAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIKKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKVEGKALYKLQAIFLEDWLYASSGLNTYSWDPFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAISGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDKIATIGTANMDVRSFELNYEIISVLYESETVHDIKRDFEDDFKHS
TEIKWNAFQKRSIKKRILESFMRLISPLL
>Mature_509_residues
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGVLWSITIVGISFVIFIENRSPQSTLAWFLVLALLPVIGVLLYSIFG
RSRWRRKKHLHRSEEQRKLFREILEGRRLELSLKVPLSERSVHLTEVVQKFGGGPAADRTTTKLLTNGDQTFSEILQAIE
QAKHHIHIQYYIYKSDEIGTKVRDALIKKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKVEGKALYKLQAIFLEDWLYASSGLNTYSWDPFMNRQYFP
GKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSIWIATPYFIPDQETLTLLRLSAISGIDVRILYPGKSDSIIS
DQASQSYFTPLLKAGASIYSYKDGFMHAKIVLVDDKIATIGTANMDVRSFELNYEIISVLYESETVHDIKRDFEDDFKHS
TEIKWNAFQKRSIKKRILESFMRLISPLL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=497, Percent_Identity=27.5653923541247, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1787007, Length=330, Percent_Identity=27.8787878787879, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI87081826, Length=381, Percent_Identity=26.7716535433071, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 58110; Mature: 58110

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGVLWSITIVGISFVIFIENRSPQSTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHH
WFLVLALLPVIGVLLYSIFGRSRWRRKKHLHRSEEQRKLFREILEGRRLELSLKVPLSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
SVHLTEVVQKFGGGPAADRTTTKLLTNGDQTFSEILQAIEQAKHHIHIQYYIYKSDEIGT
CCHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCH
KVRDALIKKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKVEGKALYKLQAIFLEDWLY
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
ASSGLNTYSWDPFMNRQYFPGKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSI
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
WIATPYFIPDQETLTLLRLSAISGIDVRILYPGKSDSIISDQASQSYFTPLLKAGASIYS
EEECCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHEE
YKDGFMHAKIVLVDDKIATIGTANMDVRSFELNYEIISVLYESETVHDIKRDFEDDFKHS
ECCCCEEEEEEEEECCEEEEECCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCC
TEIKWNAFQKRSIKKRILESFMRLISPLL
CCCEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKPIVQLLLIFTIVSIVLFLLNTSYISLYTFVGVLWSITIVGISFVIFIENRSPQSTLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHH
WFLVLALLPVIGVLLYSIFGRSRWRRKKHLHRSEEQRKLFREILEGRRLELSLKVPLSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
SVHLTEVVQKFGGGPAADRTTTKLLTNGDQTFSEILQAIEQAKHHIHIQYYIYKSDEIGT
CCHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCH
KVRDALIKKAKDGVIVRFLYDGLGSNTLRRRFLQPMKEAGIEIVEFDPIFSAWLLETVNY
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCC
RNHRKIVIVDGEIGFTGGLNVGDEYLGRSKKFPVWRDSHLKVEGKALYKLQAIFLEDWLY
CCCCEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
ASSGLNTYSWDPFMNRQYFPGKEISNAEGAVQIVASGPSSDDKSIRNTLLAVMGSAKKSI
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEE
WIATPYFIPDQETLTLLRLSAISGIDVRILYPGKSDSIISDQASQSYFTPLLKAGASIYS
EEECCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHEE
YKDGFMHAKIVLVDDKIATIGTANMDVRSFELNYEIISVLYESETVHDIKRDFEDDFKHS
ECCCCEEEEEEEEECCEEEEECCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCC
TEIKWNAFQKRSIKKRILESFMRLISPLL
CCCEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]