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The map label for this gene is cadA [H]

Identifier: 218901791

GI number: 218901791

Start: 621542

End: 623908

Strand: Direct

Name: cadA [H]

Synonym: BCAH820_0652

Alternate gene names: 218901791

Gene position: 621542-623908 (Clockwise)

Preceding gene: 218901790

Following gene: 218901793

Centisome position: 11.72

GC content: 36.88

Gene sequence:

>2367_bases
ATGGCTGAAGCATTAGTGAAAAAGAAACTGATGTTAGAAGGTTTAGATTGTGCGAACTGTGCAATGAAAATTGAAAAAGG
CGTTGGAAATATAGAAGGAGTAAATTCTTGCTCTGTAAATTTCGCGACAAAAACAATGGTTTTAGAAACAGCGCAAAATA
AAGAAAGTGAAGTTGTTACAGAAGCAAAACAACTCGTTACAAAATTAGAACCGCATATTAAAGTGCAAGAAGAAAAAAAC
ACAAAAGTAGCAAAAGAAGTGTTTATATTAGAAGGTTTAGATTGCGCGAACTGTGCGATGAAGATTGAAAATAAAGTTAA
GGAAATGCCGACTGTTTCAGCAGCAACTGTTGATTTCGTATCAAAGAAATTACGAGTTGAAGTAGCAAATAAAAGAGAAT
TAGAAGCGACTGTAGCGAATATAACAAATGTCGTTCAAAAGTTAGAACCAGATGTGAAAGTTGTTCGTGAAGAAAAGGGT
GGTCATGACCACGGACATAGTCACGATCATGGTGAAGCAAATGTGAAAAAGATGGTAGGCCGATTAGTGGTCGGCGGAAT
TTTGACAGCAATTGCTGCATTAGCGGGCTTACCACAAATGGTAACAATTCCGTTATTCGTCCTTGCTTATTTATTAATAG
GTGGAGATATCGTTTGGAGAGCGGTAAGAAACATAACTCGTGGCCAAGTATTTGATGAAAACTTCTTAATGGCAATTGCA
ACTGTAGGAGCTTTTGCAATTCAACAATACTCAGAAGCTGTAGCAGTAATGCTATTTTATCAAGTAGGAGAACTATTCCA
AAGCATTGCGGTAAACCGCTCTCGAAAATCAATTACTTCATTAATGGATATTCGTCCTGATTATGCGAATGTAAAGGTTG
GAAATGAAACGAAACAAGTATCACCAGAAGATGTACAGATTGGCGATTATATTATCGTTAAGCCAGGTGAGAAAGTACCG
TTAGACGGAAAAGTAATTGAAGGAACATCAATGGTAGATACTTCAGCGTTAACAGGTGAATCTGTACCACGTGAAGTTGA
AGTTGGAAATGATGTATTAAGTGGCTTTGTGAACCAAAACGGTGTGTTGACAATTGAAGTTACAAAAGAATTCGGTGAAT
CAACTGTATCGAAAATTTTAGATTTAGTTCAAAATGCAAGCAGTAAAAAAGCGCCAACGGAAAACTTTATTACGAAGTTC
GCGCGTTACTATACGCCAGTTGTAGTAATTACAGCAGCGATCATGGCGTTTATTCCACCACTTATTTTAGAAGGAGCTAC
ATTCTCTGATTGGATTTATAGAGCTCTAGTGTTCTTAGTAATCTCTTGTCCATGTGCGTTAGTTGTATCCATTCCTCTTG
GATTCTTTGGAGGTATCGGTGGTGCATCTAAAAGTGGTGTGTTAGTAAAAGGTAGTAACTATTTAGAAGCTTTAAATGAT
GTGAAATATATTGTTTTTGACAAAACAGGAACATTAACAAAAGGTGTTTTCAAAGTTACAAAAATGGAACCGAGCGAAGG
TACTACAAGTGAAGAGTTATTAGAGTATGCGGCATTTGCTGAAGTATATTCTAACCATCCAATTGCCCAATCTATTCGAA
AGGCATATGGAAAATCAATTGATGAAAAAATAATCGATGATTATAACGAAATTTCTGGTCACGGTACAGTCGTAAAAGTA
CAAGGAAAAGAAATTTTTGCAGGTAATGCAAAATTAATGAGAAAAGAAAATATTACATTTAAGCAACCAGAAACAGTAGG
TACATTAGTTCACGTTGCTGTAGATGGAAGATATGCAGGTTATATTGTTATCTCTGATGAGGTAAAAGAGGATTCGAAAC
AAGCGATTCAAAAGTTAAAAGAACTAGGTATTAAAAAGACAGTAATGTTAACTGGTGATGCAAAGCCAGTTGGTGAAGCT
GTCGGTAAAGAATTAGGCTTAGATGAAGTTCATGCGGAATTACTACCGCAACAAAAAGTAGAAGAGATTGAAAAAATTGA
TGCAGCGAAGCACGGAAAAGAAAAAATTGCCTTCGTTGGTGACGGTATTAACGATACACCAGTATTAGCCCGTGCAGATG
TTGGTATTGCGATGGGTGGTTTAGGGTCAGATGCAGCAATTGAAGCGGCAGACATCGTTATTATGACTGATGAGCCTTCA
AAAATTGCGACAGCTGTAAAAATTGCAAAACGCACAAGAAGTATAGTGTGGCAAAATATCATCTTTGCTCTAGGTGTAAA
AGGGATCGTTCTATTACTTGGTGCCTTTGGTATTGCAACAATGTGGGAAGCTGTTTTCTCAGATGTTGGTGTGACACTAC
TTGCAGTGTTAAATGCAATGCGTGTATTACGAGTGAAAGATTTATAA

Upstream 100 bases:

>100_bases
TTATTATTCGTTAGCTGACCAACACGTCATTCATATCTTCGAGCAAGCGTTTGAACACGTAAACGAGGAAGAATAAAAAA
GAACGCGAGGAGGGAGAACG

Downstream 100 bases:

>100_bases
AAAAGAGGACGCGAACCGCGTCCTCTTTTTTATTGGTGATTTTGTTGAAATTGACTCAATAAAATAATATCAAATACTAT
TTTACTTTAAAATAGTATAA

Product: heavy metal-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 787

Protein sequence:

>788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKN
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVIEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGTTSEELLEYAAFAEVYSNHPIAQSIRKAYGKSIDEKIIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKPVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKIAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVKIAKRTRSIVWQNIIFALGVKGIVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Sequences:

>Translated_788_residues
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKN
TKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKG
GHDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVP
LDGKVIEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKF
ARYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
VKYIVFDKTGTLTKGVFKVTKMEPSEGTTSEELLEYAAFAEVYSNHPIAQSIRKAYGKSIDEKIIDDYNEISGHGTVVKV
QGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKPVGEA
VGKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKIAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
KIATAVKIAKRTRSIVWQNIIFALGVKGIVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL
>Mature_787_residues
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVTEAKQLVTKLEPHIKVQEEKNT
KVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFVSKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGG
HDHGHSHDHGEANVKKMVGRLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIAT
VGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVPL
DGKVIEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQNGVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFA
RYYTPVVVITAAIMAFIPPLILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALNDV
KYIVFDKTGTLTKGVFKVTKMEPSEGTTSEELLEYAAFAEVYSNHPIAQSIRKAYGKSIDEKIIDDYNEISGHGTVVKVQ
GKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKPVGEAV
GKELGLDEVHAELLPQQKVEEIEKIDAAKHGKEKIAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSK
IATAVKIAKRTRSIVWQNIIFALGVKGIVLLLGAFGIATMWEAVFSDVGVTLLAVLNAMRVLRVKDL

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=869, Percent_Identity=25.2013808975834, Blast_Score=257, Evalue=3e-68,
Organism=Homo sapiens, GI55743073, Length=543, Percent_Identity=28.5451197053407, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI115529486, Length=644, Percent_Identity=25, Blast_Score=166, Evalue=1e-40,
Organism=Homo sapiens, GI118498343, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1789879, Length=716, Percent_Identity=33.7988826815642, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786691, Length=853, Percent_Identity=27.432590855803, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1786914, Length=524, Percent_Identity=28.4351145038168, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI2367363, Length=592, Percent_Identity=24.4932432432432, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17556548, Length=901, Percent_Identity=26.7480577136515, Blast_Score=221, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6320475, Length=560, Percent_Identity=30.5357142857143, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=635, Percent_Identity=25.0393700787402, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325221, Length=565, Percent_Identity=22.6548672566372, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321430, Length=571, Percent_Identity=22.0665499124343, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321271, Length=220, Percent_Identity=26.3636363636364, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329854, Length=610, Percent_Identity=27.7049180327869, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=26.7515923566879, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=26.7515923566879, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=26.7515923566879, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=26.7515923566879, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=26.7515923566879, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366676, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 85158; Mature: 85027

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVT
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHEEEHHCCCHHHHHH
EAKQLVTKLEPHIKVQEEKNTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFV
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHH
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVIEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGTTSEELLEYAAFAEVYSNHPIAQSIRKAYGKSI
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
DEKIIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGRYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCHHCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKPVGEAVGKELGLDEVHAELLPQQKV
EEEEECHHCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKIAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVKIAKRTRSIVWQNIIFALGVKGIVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC
>Mature Secondary Structure 
AEALVKKKLMLEGLDCANCAMKIEKGVGNIEGVNSCSVNFATKTMVLETAQNKESEVVT
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHEEEHHCCCHHHHHH
EAKQLVTKLEPHIKVQEEKNTKVAKEVFILEGLDCANCAMKIENKVKEMPTVSAATVDFV
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SKKLRVEVANKRELEATVANITNVVQKLEPDVKVVREEKGGHDHGHSHDHGEANVKKMVG
HHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
RLVVGGILTAIAALAGLPQMVTIPLFVLAYLLIGGDIVWRAVRNITRGQVFDENFLMAIA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHH
TVGAFAIQQYSEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPDYANVKVGNETKQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCC
SPEDVQIGDYIIVKPGEKVPLDGKVIEGTSMVDTSALTGESVPREVEVGNDVLSGFVNQN
CCCCEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHCCHHHHHHHCCCC
GVLTIEVTKEFGESTVSKILDLVQNASSKKAPTENFITKFARYYTPVVVITAAIMAFIPP
CEEEEEEHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILEGATFSDWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGVLVKGSNYLEALND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCC
VKYIVFDKTGTLTKGVFKVTKMEPSEGTTSEELLEYAAFAEVYSNHPIAQSIRKAYGKSI
CEEEEEECCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
DEKIIDDYNEISGHGTVVKVQGKEIFAGNAKLMRKENITFKQPETVGTLVHVAVDGRYAG
HHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHEECCCCCCCCCHHCEEEEEEECCCEEE
YIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKPVGEAVGKELGLDEVHAELLPQQKV
EEEEECHHCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHCCHHHH
EEIEKIDAAKHGKEKIAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPS
HHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCCEEECCCCCCCCEEEEEEEEECCCCH
KIATAVKIAKRTRSIVWQNIIFALGVKGIVLLLGAFGIATMWEAVFSDVGVTLLAVLNAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVLRVKDL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]