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The map label for this gene is dut [H]

Identifier: 218901706

GI number: 218901706

Start: 537778

End: 538293

Strand: Direct

Name: dut [H]

Synonym: BCAH820_0567

Alternate gene names: 218901706

Gene position: 537778-538293 (Clockwise)

Preceding gene: 218901705

Following gene: 218901707

Centisome position: 10.14

GC content: 40.12

Gene sequence:

>516_bases
ATGAAGTTAAGTGTAAAAATTAAACGTTTAAATGAATCAGTGGAGATTCCTAAATATGCGAAGCCTGGTGACGCAGGCTT
CGATCTAGTAGCAGCAGAGGATGTAATTATTAAGCCGGGTGAAACAAAGGTAATACCTACAGGTCTTGCGTTCGAAATTC
CACCAGGATATGAAATGCAAATAAGACCACGTAGCGGAATGTCACGTAAAACAAAATTGCGAGTAGTTTTAGGGACTATC
GATAGTGGATATAGAGGAGAAGTTGGCGTGATTGCAGATAATGTTTCAATTATCGAATACACATCTCAACCAAGGTTGTT
AATGGGAGCGTTTGCTGGAGATAAAGACTTCAATGTTACGAAAGCGACTAAATATGAAGTAATTAAAATTAGTAAGGGTG
ACAGAATTGCTCAAGGCGTCATAGCACCAGTAGTAACAGCTCATTTTGAAGAAGTGGACGAGCTATCGGATAGTGAGCGT
GGAGTTGGAGGTTTCGGATCTACGGGAGTTAAGTAA

Upstream 100 bases:

>100_bases
TGGTCATGGTGAGCAATCATTTGTATATAAAAGCGGAAAAGTAACTCGTATGGATGAACGGAAAACGCAGTTAATCTAAT
GAAGGATGGAGAGGGACGGA

Downstream 100 bases:

>100_bases
GACTAAATTTGAATTTTATAAGAAAAGGGGAATGAAAATGAGATACACGCGTAATAGACAAATCAAGAAAGCCAATGAGG
ATTATTTTTATGAATTAATC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase)

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MKLSVKIKRLNESVEIPKYAKPGDAGFDLVAAEDVIIKPGETKVIPTGLAFEIPPGYEMQIRPRSGMSRKTKLRVVLGTI
DSGYRGEVGVIADNVSIIEYTSQPRLLMGAFAGDKDFNVTKATKYEVIKISKGDRIAQGVIAPVVTAHFEEVDELSDSER
GVGGFGSTGVK

Sequences:

>Translated_171_residues
MKLSVKIKRLNESVEIPKYAKPGDAGFDLVAAEDVIIKPGETKVIPTGLAFEIPPGYEMQIRPRSGMSRKTKLRVVLGTI
DSGYRGEVGVIADNVSIIEYTSQPRLLMGAFAGDKDFNVTKATKYEVIKISKGDRIAQGVIAPVVTAHFEEVDELSDSER
GVGGFGSTGVK
>Mature_171_residues
MKLSVKIKRLNESVEIPKYAKPGDAGFDLVAAEDVIIKPGETKVIPTGLAFEIPPGYEMQIRPRSGMSRKTKLRVVLGTI
DSGYRGEVGVIADNVSIIEYTSQPRLLMGAFAGDKDFNVTKATKYEVIKISKGDRIAQGVIAPVVTAHFEEVDELSDSER
GVGGFGSTGVK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=167, Percent_Identity=34.7305389221557, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI4503423, Length=167, Percent_Identity=34.7305389221557, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI70906441, Length=167, Percent_Identity=34.7305389221557, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1790071, Length=175, Percent_Identity=33.1428571428571, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71988561, Length=168, Percent_Identity=33.9285714285714, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319729, Length=166, Percent_Identity=31.9277108433735, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921126, Length=167, Percent_Identity=29.940119760479, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583610, Length=167, Percent_Identity=29.940119760479, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 18442; Mature: 18442

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSVKIKRLNESVEIPKYAKPGDAGFDLVAAEDVIIKPGETKVIPTGLAFEIPPGYEMQ
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEECCCCCEEEECCEEEECCCCCEEE
IRPRSGMSRKTKLRVVLGTIDSGYRGEVGVIADNVSIIEYTSQPRLLMGAFAGDKDFNVT
EECCCCCCCCEEEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCCCCCCEE
KATKYEVIKISKGDRIAQGVIAPVVTAHFEEVDELSDSERGVGGFGSTGVK
ECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLSVKIKRLNESVEIPKYAKPGDAGFDLVAAEDVIIKPGETKVIPTGLAFEIPPGYEMQ
CCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEECCCCCEEEECCEEEECCCCCEEE
IRPRSGMSRKTKLRVVLGTIDSGYRGEVGVIADNVSIIEYTSQPRLLMGAFAGDKDFNVT
EECCCCCCCCEEEEEEEEECCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCCCCCCEE
KATKYEVIKISKGDRIAQGVIAPVVTAHFEEVDELSDSERGVGGFGSTGVK
ECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA