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The map label for this gene is sipS1 [H]

Identifier: 218901617

GI number: 218901617

Start: 449999

End: 450532

Strand: Direct

Name: sipS1 [H]

Synonym: BCAH820_0459

Alternate gene names: 218901617

Gene position: 449999-450532 (Clockwise)

Preceding gene: 218901615

Following gene: 218901619

Centisome position: 8.49

GC content: 32.58

Gene sequence:

>534_bases
ATGCAAAAGAAAAAACGTTTGCGTGAATTCTTTGGAACAATTGCAATTGCTTGTTTGCTGGTGTTTTTGGCGAAAATTTT
CGTGTTTTTTCCTACGACTGTAAAAGGGGCGTCCATGAAGCCAACGTTACAAGATGGGGATAAGGTAATTGTGAATAAGT
TAGCAAAGCAATTTGAAAGTTATGGGAGAGAAGATATTATTGTTGTAAAGACGGATAATTCTTATGTAAAAAGGGTTATT
GGTTTGCCTGGTGATGTCATTGAGGTGAGAAATGATCAATTATATGTGAATCATGAAGTAATAGAGGAAGCGTATTTGTA
TAGTAATAAGAAACAAGCTGAAAAAAAACTTATGAATTTAACAGAAGACTTTGGACCGATTACAGTTCCTAAAAATAAGA
TTTTTGTTATGGGAGATAATCGCTTAATAAGCAGAGATAGTAGAAATGGTTTAGGACTCATTGATAAGGCTGATGTATTA
GGAGAATTAGCGGCAATTTATTATCCATTTGAACATATGAAAATAATAAATTAA

Upstream 100 bases:

>100_bases
TAATTTTGTAATATTGTAGTTTTTAGATTCAGAATTTTGTGGAAAAAAAGTGGTTGAAGTCTTTATAATAAAAGTAAAAA
GATGATGAGATGGTGGAATG

Downstream 100 bases:

>100_bases
AGTAAAAAACCAAGCAAATTTCAGTTTGCTTGGTTTTTATGTTAAATCGTAGGAGACTCATTAAATTCATAGACGTCTTC
ATTTTTTTTGTGCGTACTTA

Product: signal peptidase I S

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MQKKKRLREFFGTIAIACLLVFLAKIFVFFPTTVKGASMKPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNSYVKRVI
GLPGDVIEVRNDQLYVNHEVIEEAYLYSNKKQAEKKLMNLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGLIDKADVL
GELAAIYYPFEHMKIIN

Sequences:

>Translated_177_residues
MQKKKRLREFFGTIAIACLLVFLAKIFVFFPTTVKGASMKPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNSYVKRVI
GLPGDVIEVRNDQLYVNHEVIEEAYLYSNKKQAEKKLMNLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGLIDKADVL
GELAAIYYPFEHMKIIN
>Mature_177_residues
MQKKKRLREFFGTIAIACLLVFLAKIFVFFPTTVKGASMKPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNSYVKRVI
GLPGDVIEVRNDQLYVNHEVIEEAYLYSNKKQAEKKLMNLTEDFGPITVPKNKIFVMGDNRLISRDSRNGLGLIDKADVL
GELAAIYYPFEHMKIIN

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20177; Mature: 20177

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKKRLREFFGTIAIACLLVFLAKIFVFFPTTVKGASMKPTLQDGDKVIVNKLAKQFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGREDIIVVKTDNSYVKRVIGLPGDVIEVRNDQLYVNHEVIEEAYLYSNKKQAEKKLMNL
CCCCCEEEEECCCHHHHHHHCCCCCEEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHH
TEDFGPITVPKNKIFVMGDNRLISRDSRNGLGLIDKADVLGELAAIYYPFEHMKIIN
HHHCCCEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEECC
>Mature Secondary Structure
MQKKKRLREFFGTIAIACLLVFLAKIFVFFPTTVKGASMKPTLQDGDKVIVNKLAKQFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGREDIIVVKTDNSYVKRVIGLPGDVIEVRNDQLYVNHEVIEEAYLYSNKKQAEKKLMNL
CCCCCEEEEECCCHHHHHHHCCCCCEEEECCCEEEEHHHHHHHHHHHCCHHHHHHHHHHH
TEDFGPITVPKNKIFVMGDNRLISRDSRNGLGLIDKADVLGELAAIYYPFEHMKIIN
HHHCCCEECCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]