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The map label for this gene is glmU [C]

Identifier: 218884645

GI number: 218884645

Start: 1243809

End: 1245092

Strand: Reverse

Name: glmU [C]

Synonym: DKAM_1334

Alternate gene names: 218884645

Gene position: 1245092-1243809 (Counterclockwise)

Preceding gene: 218884646

Following gene: 218884644

Centisome position: 91.2

GC content: 43.46

Gene sequence:

>1284_bases
TTGAAGGCGGTTATATTAGCCGCTGGAAACGGGATCAGGCTTAAACCAATAACCGAGACCCGCCCTAAACCATTGATACC
AATCCTATGTAAGCCATTGTTGGACTGGCACCTTGATAGGCTTGCAGCCGTCTCGTTCATAGATGAAGTGGTTATTGTAA
CAGGATATATGGGGGATATTATTAGAGCACATGTGATGAGCAGGAGACTACCCTTTAAGGTGAGATTCGTAGAGCAGGGT
GAACCAAGGGGAACAGGGGATGCTGTTGTTAAGGGTATTGAAGGAATGGGTAGTGACGATGACGTCCTAATCATTTACTC
TGACATCTTCACACCGGTAAACATTATCCCAGAGATTGCGGGGGAAAGCGGAAACATTATTGTAGGTAGCGAAGTAGATA
ACCCAAGCGACTACGGAGTACTTATTAATGAAGGTAACTATTTCAAAGGAGTCGTGGAGAAACCCATGAACCCTCCCTCG
AGACTAGTCAACGCGGGCATATATAAGTTGAGAACCCGTGACATCCTAGATAATAGCGATATAAAGCCGAGCCCACGTGG
AGAATTAGAGTTCACTGATGTATTAAATAATATGAGTAGGAGAGGGGTGAAGATTAGAATCTACAAGTTACCGAGGGCGT
TATGGATCGATATAGGTAAGCCATGGCATGTAATAGAGGCAAACAAGATGGCTTTAACAATGGTTAAAAAAGAGATAAAG
GGAAGAGTCATAGAACCCTCCCATATAATCGGTGAGGTCTATATTGGAGAAAACTCCTTAGTGAACCCATTTACAATGAT
AGAGGGACCAGCATATATAGATCGAGAGGTCGAAATAGGGCCGAACGCTAGAATCAGGCCTTGGAGTGTTATATGTAGGG
GTTCCAAAATAGGCTTCAGCGTTGAAGTCAAGGAGAGCATAATACTAGAAAATGTGCACGCCAGTCATCTCACGTACATC
GGTGACAGTATAGTATGTGAAAACGTCAACCTCGGCGCTGGAACGATAACAGCTAATTTAAGGTTTGACGAGGCAACGGT
TAAAATGCTTATAAAAGACCATGTGGAGGACACCGGCAGAAAGAAAATGGGTGCTGTGATAGGGGCTAATGTGAAAACAG
GTGTTAATGTATCGCTGATGCCCGGGGTGAAAATAGGGAGTGATACATGGATTATGCCTGGCTCAGTTGTATATAGGGAT
GTGGCCTCGAACTCTATTTATTACAGTGATGGAAGAGTAGAGATAAAAACCGGGTTGAATAAAGATAGAATCAGTGAGAA
ATAA

Upstream 100 bases:

>100_bases
ACCACTCTAGTGTGAAGTATCAGTATTCAAGTGGGATGAAGGTTATTAATAATTTCTCAATTTATGTTTATGTTTATGTT
AGAGCTGGGGGAGGCTTGTT

Downstream 100 bases:

>100_bases
TGGCGGACACATATAGAATAAATGACTTCAAGAAAAAATACCCGCATCTAGCTAGAGAGGTACTCGAGGAGAAAGATATA
TCTCTAAAATTAAGCGTGAA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKAVILAAGNGIRLKPITETRPKPLIPILCKPLLDWHLDRLAAVSFIDEVVIVTGYMGDIIRAHVMSRRLPFKVRFVEQG
EPRGTGDAVVKGIEGMGSDDDVLIIYSDIFTPVNIIPEIAGESGNIIVGSEVDNPSDYGVLINEGNYFKGVVEKPMNPPS
RLVNAGIYKLRTRDILDNSDIKPSPRGELEFTDVLNNMSRRGVKIRIYKLPRALWIDIGKPWHVIEANKMALTMVKKEIK
GRVIEPSHIIGEVYIGENSLVNPFTMIEGPAYIDREVEIGPNARIRPWSVICRGSKIGFSVEVKESIILENVHASHLTYI
GDSIVCENVNLGAGTITANLRFDEATVKMLIKDHVEDTGRKKMGAVIGANVKTGVNVSLMPGVKIGSDTWIMPGSVVYRD
VASNSIYYSDGRVEIKTGLNKDRISEK

Sequences:

>Translated_427_residues
MKAVILAAGNGIRLKPITETRPKPLIPILCKPLLDWHLDRLAAVSFIDEVVIVTGYMGDIIRAHVMSRRLPFKVRFVEQG
EPRGTGDAVVKGIEGMGSDDDVLIIYSDIFTPVNIIPEIAGESGNIIVGSEVDNPSDYGVLINEGNYFKGVVEKPMNPPS
RLVNAGIYKLRTRDILDNSDIKPSPRGELEFTDVLNNMSRRGVKIRIYKLPRALWIDIGKPWHVIEANKMALTMVKKEIK
GRVIEPSHIIGEVYIGENSLVNPFTMIEGPAYIDREVEIGPNARIRPWSVICRGSKIGFSVEVKESIILENVHASHLTYI
GDSIVCENVNLGAGTITANLRFDEATVKMLIKDHVEDTGRKKMGAVIGANVKTGVNVSLMPGVKIGSDTWIMPGSVVYRD
VASNSIYYSDGRVEIKTGLNKDRISEK
>Mature_427_residues
MKAVILAAGNGIRLKPITETRPKPLIPILCKPLLDWHLDRLAAVSFIDEVVIVTGYMGDIIRAHVMSRRLPFKVRFVEQG
EPRGTGDAVVKGIEGMGSDDDVLIIYSDIFTPVNIIPEIAGESGNIIVGSEVDNPSDYGVLINEGNYFKGVVEKPMNPPS
RLVNAGIYKLRTRDILDNSDIKPSPRGELEFTDVLNNMSRRGVKIRIYKLPRALWIDIGKPWHVIEANKMALTMVKKEIK
GRVIEPSHIIGEVYIGENSLVNPFTMIEGPAYIDREVEIGPNARIRPWSVICRGSKIGFSVEVKESIILENVHASHLTYI
GDSIVCENVNLGAGTITANLRFDEATVKMLIKDHVEDTGRKKMGAVIGANVKTGVNVSLMPGVKIGSDTWIMPGSVVYRD
VASNSIYYSDGRVEIKTGLNKDRISEK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=348, Percent_Identity=26.7241379310345, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI11761619, Length=336, Percent_Identity=26.4880952380952, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790168, Length=466, Percent_Identity=25.3218884120172, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790224, Length=249, Percent_Identity=28.9156626506024, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788351, Length=246, Percent_Identity=28.4552845528455, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133931050, Length=342, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509979, Length=328, Percent_Identity=26.219512195122, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17509981, Length=314, Percent_Identity=25.4777070063694, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=342, Percent_Identity=24.2690058479532, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355443, Length=334, Percent_Identity=26.9461077844311, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644084, Length=334, Percent_Identity=26.9461077844311, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47109; Mature: 47109

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAAGNGIRLKPITETRPKPLIPILCKPLLDWHLDRLAAVSFIDEVVIVTGYMGDI
CCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHH
IRAHVMSRRLPFKVRFVEQGEPRGTGDAVVKGIEGMGSDDDVLIIYSDIFTPVNIIPEIA
HHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHC
GESGNIIVGSEVDNPSDYGVLINEGNYFKGVVEKPMNPPSRLVNAGIYKLRTRDILDNSD
CCCCCEEEECCCCCCCCCEEEEECCCEEEHHHHCCCCCHHHHHHCCEEEEEEHHCCCCCC
IKPSPRGELEFTDVLNNMSRRGVKIRIYKLPRALWIDIGKPWHVIEANKMALTMVKKEIK
CCCCCCCCEEHHHHHHHHHHCCEEEEEEECCCEEEEECCCCEEEEECCCHHHHHHHHHHC
GRVIEPSHIIGEVYIGENSLVNPFTMIEGPAYIDREVEIGPNARIRPWSVICRGSKIGFS
CCEECCCCEEEEEEECCCCCCCCEEEECCCCEECCEEEECCCCCCCCEEEEEECCCCCEE
VEVKESIILENVHASHLTYIGDSIVCENVNLGAGTITANLRFDEATVKMLIKDHVEDTGR
EEECHHEEEECCCHHHHEECCCEEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHCCH
KKMGAVIGANVKTGVNVSLMPGVKIGSDTWIMPGSVVYRDVASNSIYYSDGRVEIKTGLN
HHHHHEEECCCCCCCEEEEECCEEECCCCEECCCHHEEEECCCCEEEEECCEEEEECCCC
KDRISEK
HHHCCCC
>Mature Secondary Structure
MKAVILAAGNGIRLKPITETRPKPLIPILCKPLLDWHLDRLAAVSFIDEVVIVTGYMGDI
CCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHH
IRAHVMSRRLPFKVRFVEQGEPRGTGDAVVKGIEGMGSDDDVLIIYSDIFTPVNIIPEIA
HHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHC
GESGNIIVGSEVDNPSDYGVLINEGNYFKGVVEKPMNPPSRLVNAGIYKLRTRDILDNSD
CCCCCEEEECCCCCCCCCEEEEECCCEEEHHHHCCCCCHHHHHHCCEEEEEEHHCCCCCC
IKPSPRGELEFTDVLNNMSRRGVKIRIYKLPRALWIDIGKPWHVIEANKMALTMVKKEIK
CCCCCCCCEEHHHHHHHHHHCCEEEEEEECCCEEEEECCCCEEEEECCCHHHHHHHHHHC
GRVIEPSHIIGEVYIGENSLVNPFTMIEGPAYIDREVEIGPNARIRPWSVICRGSKIGFS
CCEECCCCEEEEEEECCCCCCCCEEEECCCCEECCEEEECCCCCCCCEEEEEECCCCCEE
VEVKESIILENVHASHLTYIGDSIVCENVNLGAGTITANLRFDEATVKMLIKDHVEDTGR
EEECHHEEEECCCHHHHEECCCEEEEECCCCCCEEEEEEEEECHHHHHHHHHHHHHHCCH
KKMGAVIGANVKTGVNVSLMPGVKIGSDTWIMPGSVVYRDVASNSIYYSDGRVEIKTGLN
HHHHHEEECCCCCCCEEEEECCEEECCCCEECCCHHEEEECCCCEEEEECCEEEEECCCC
KDRISEK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA