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The map label for this gene is 218884634

Identifier: 218884634

GI number: 218884634

Start: 1235372

End: 1236232

Strand: Reverse

Name: 218884634

Synonym: DKAM_1323

Alternate gene names: NA

Gene position: 1236232-1235372 (Counterclockwise)

Preceding gene: 218884635

Following gene: 218884633

Centisome position: 90.55

GC content: 43.44

Gene sequence:

>861_bases
ATGAGTATAACACCCGAGAAAGAGCCTTTACTACCTAGAATACAGGTGGAAAACATAGTTAAATCCATAAAGAAAGGAGA
GAGAATAGACGGTAGGGGTTTAACTGATTACCGGCCTATAGAAGTGATATTGAACCCTATAACCAAGGCATCCGGTAGTT
CCCTTGTTAAGCTAGGAGGTACACAGGTAATAGCAGGCGTAAAGCTTGAACTAGAGGAGCCCTTCCCGGATAGACCTGGG
GAAGGAGTTTTACAAGTACATGCTGAGTTTGTTCCATTAGCATCACCATCATTCGAGCCCGGTCCACCAGATGAAAACGC
GATAGAGGTTGCAAGGGTTATTGATAGATCACTAAGGGAATCCAAGGCTGTTAAGCTGGATGCATTAGCCATAGAGCCGG
GAAAAATAGTGTGGAGTGTCTACACGGATATCTACCTGGTGGATCACCAGGGCAACATTATCGATACCGGCATGCTTGCC
TCAATGCTCGCCCTGGCAACATCAAGGATTCCAGAGTTAATTAAAGGCGAGAACGGGTATAAAGTAGACCATACCAAGTA
TGTTGGCCCATTACCGATAAATACGTTGGTGGCCACTGTTACAATGGGTATCTACAACGATGTAATAATCGTTGATCCCC
TACTCGAGGAGGAGGCTGTAATAGATTCATTCATAACTATCGCTATCGATGAGTCAGGCAGGATCTGTGGTATACAAAAA
AGAGGGATGAAAGGATTCTCTAGAAGCGTTCTCGATAACACTATTGAAATAGCGCTATCTAAGGGACGAGAACTCGTGGA
CTTAATGAAGAAAATATTAAATAACCCAAGTGAATACATGAAACCCTTAGTATCAGAGTAA

Upstream 100 bases:

>100_bases
GCACTAGACATGGCTTACAAAGGAGTCGAACAAATCTATAAAACCGCGAAGGAGGCAATGTACCGTAAGTATTACAAGAT
GTTTGAGGAGGTGAGGTAGA

Downstream 100 bases:

>100_bases
GTATACATGGTGAATGCTTATGGGTAAGACAAAGGTAGTTGGGATAGCAGGTAGATATGGGACAAGATATGGTTCAACCC
TCAGGAAAAAAATACGTGAT

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSITPEKEPLLPRIQVENIVKSIKKGERIDGRGLTDYRPIEVILNPITKASGSSLVKLGGTQVIAGVKLELEEPFPDRPG
EGVLQVHAEFVPLASPSFEPGPPDENAIEVARVIDRSLRESKAVKLDALAIEPGKIVWSVYTDIYLVDHQGNIIDTGMLA
SMLALATSRIPELIKGENGYKVDHTKYVGPLPINTLVATVTMGIYNDVIIVDPLLEEEAVIDSFITIAIDESGRICGIQK
RGMKGFSRSVLDNTIEIALSKGRELVDLMKKILNNPSEYMKPLVSE

Sequences:

>Translated_286_residues
MSITPEKEPLLPRIQVENIVKSIKKGERIDGRGLTDYRPIEVILNPITKASGSSLVKLGGTQVIAGVKLELEEPFPDRPG
EGVLQVHAEFVPLASPSFEPGPPDENAIEVARVIDRSLRESKAVKLDALAIEPGKIVWSVYTDIYLVDHQGNIIDTGMLA
SMLALATSRIPELIKGENGYKVDHTKYVGPLPINTLVATVTMGIYNDVIIVDPLLEEEAVIDSFITIAIDESGRICGIQK
RGMKGFSRSVLDNTIEIALSKGRELVDLMKKILNNPSEYMKPLVSE
>Mature_285_residues
SITPEKEPLLPRIQVENIVKSIKKGERIDGRGLTDYRPIEVILNPITKASGSSLVKLGGTQVIAGVKLELEEPFPDRPGE
GVLQVHAEFVPLASPSFEPGPPDENAIEVARVIDRSLRESKAVKLDALAIEPGKIVWSVYTDIYLVDHQGNIIDTGMLAS
MLALATSRIPELIKGENGYKVDHTKYVGPLPINTLVATVTMGIYNDVIIVDPLLEEEAVIDSFITIAIDESGRICGIQKR
GMKGFSRSVLDNTIEIALSKGRELVDLMKKILNNPSEYMKPLVSE

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential) [H]

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family [H]

Homologues:

Organism=Homo sapiens, GI31415882, Length=269, Percent_Identity=33.457249070632, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI77812672, Length=280, Percent_Identity=30.7142857142857, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI77812670, Length=280, Percent_Identity=30.7142857142857, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI189083688, Length=230, Percent_Identity=30.8695652173913, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144570, Length=273, Percent_Identity=24.1758241758242, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320486, Length=290, Percent_Identity=26.551724137931, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28573444, Length=271, Percent_Identity=27.6752767527675, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642649, Length=257, Percent_Identity=24.124513618677, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568 [H]

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C [H]

EC number: 3.1.13.-

Molecular weight: Translated: 31291; Mature: 31160

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPEKEPLLPRIQVENIVKSIKKGERIDGRGLTDYRPIEVILNPITKASGSSLVKLGG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECC
TQVIAGVKLELEEPFPDRPGEGVLQVHAEFVPLASPSFEPGPPDENAIEVARVIDRSLRE
EEEEEEEEEEECCCCCCCCCCCEEEEEEHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
SKAVKLDALAIEPGKIVWSVYTDIYLVDHQGNIIDTGMLASMLALATSRIPELIKGENGY
HHCEEEEEEEECCCCEEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHCHHHHCCCCCC
KVDHTKYVGPLPINTLVATVTMGIYNDVIIVDPLLEEEAVIDSFITIAIDESGRICGIQK
EECCCCEECCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHEEEEEEECCCCCEECCHH
RGMKGFSRSVLDNTIEIALSKGRELVDLMKKILNNPSEYMKPLVSE
HCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
SITPEKEPLLPRIQVENIVKSIKKGERIDGRGLTDYRPIEVILNPITKASGSSLVKLGG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECC
TQVIAGVKLELEEPFPDRPGEGVLQVHAEFVPLASPSFEPGPPDENAIEVARVIDRSLRE
EEEEEEEEEEECCCCCCCCCCCEEEEEEHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
SKAVKLDALAIEPGKIVWSVYTDIYLVDHQGNIIDTGMLASMLALATSRIPELIKGENGY
HHCEEEEEEEECCCCEEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHHHCHHHHCCCCCC
KVDHTKYVGPLPINTLVATVTMGIYNDVIIVDPLLEEEAVIDSFITIAIDESGRICGIQK
EECCCCEECCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHEEEEEEECCCCCEECCHH
RGMKGFSRSVLDNTIEIALSKGRELVDLMKKILNNPSEYMKPLVSE
HCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA