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The map label for this gene is thrC [H]

Identifier: 218884612

GI number: 218884612

Start: 1217678

End: 1218742

Strand: Reverse

Name: thrC [H]

Synonym: DKAM_1301

Alternate gene names: 218884612

Gene position: 1218742-1217678 (Counterclockwise)

Preceding gene: 218884614

Following gene: 218884608

Centisome position: 89.27

GC content: 45.45

Gene sequence:

>1065_bases
ATGAAGTGGAAGTGTAACCATTGCGGTTTCGAGGCTGACGCGTTTAGTGAATACCATTGGAGATGTCCTCGTTGTGGTGG
ACCCCTAGATCTTGTTTACGATGGTAAGCTTGAGAAAACCAGCTCGAAGAATATCTGGGAGAAATATGGCGGTACAATAC
CTTTGAAACCAGAGAAGACAAGGAGGGAGGGTAACACACCGCTAGTTGAGGAGAAAATCGATGGAATGACACTTCTCTTC
AAGCTTGAATACCTTAATCCAGGCGGTAGCTTCAAGGACCGGGGTTCAACACTAGCCATATACTATGCCTATAAATTAGG
CTTCAAGAATGTTATCGAGGATACCAGCGGTAACACAGGTATCTCGGTAGCCCTCTACTCAAGACTCTACAATTTAAAGA
CAAGAATATACATGCCTAAAACAGCCCCACCAGGTAAAAAGAAGGTCATCAAGGCGCTCGATGCGGAAATAATTGAGGCC
CCTACGCGAGGCGATGCAACTGAAATGGTTTTAAAGGAGGCACTTACGGGAGCATACTACGTGGCACATACTTGGAGCTA
CTTCTATATAATGGGGGCGTCCACAATAGCCTGGGAGGTTCTCGAAGAGGATGTACCCGACTACGTTATATCGCCAATAG
GATCAGGCGGCTTATTCCTTGGATTAGTAAAAGGATTCGAGAAGGCCCTTGAAGCAGGCTGGATAACCAAGATGCCTAGA
TTCATAGGTGTTCAAGGCTATAGCACACAACCAGTTTATAAAGCATTTAAAGGAGTCACTCAGCCAGGAGAGGACTCGAG
TCTCGCGGATGGAATAATGGTTCCAAACCCGCCTAGACTGAATGAAATAGTTAATGCGTTGCATAAATACCAGGGAGACG
TCATCCTAGTCGGCAATACCGAAATACTGAGGGCATGGAGGGAACTATGGGAGCTTGGATTCCTTGTAGAACCAACCTCT
GCATCCATTTATGCTGCACTAGAAAAGATTAAGAACCAGCTTTCAGGCAAGAAAGTACTACTAGTATTAACAGGCTCAGG
GCTGAAAAACATACCAGATATCTAG

Upstream 100 bases:

>100_bases
TTTGGGGAACCTGTCGTGGGTTCTAAATCCTAAAGAATTTTATTAGGTTTCTAAAGTTAGTTATTGATAGAGGCAAAATA
AATTACCCTGGAGATCTTTC

Downstream 100 bases:

>100_bases
TTATCTAGTTAATTGGAGAAAACTGTTAAATATAGAAGTTATAATACTTAACAAGAAGCCGTGGACATAGCCCCATGGAT
CAACCAGGACAACAGGCCAG

Product: Threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKWKCNHCGFEADAFSEYHWRCPRCGGPLDLVYDGKLEKTSSKNIWEKYGGTIPLKPEKTRREGNTPLVEEKIDGMTLLF
KLEYLNPGGSFKDRGSTLAIYYAYKLGFKNVIEDTSGNTGISVALYSRLYNLKTRIYMPKTAPPGKKKVIKALDAEIIEA
PTRGDATEMVLKEALTGAYYVAHTWSYFYIMGASTIAWEVLEEDVPDYVISPIGSGGLFLGLVKGFEKALEAGWITKMPR
FIGVQGYSTQPVYKAFKGVTQPGEDSSLADGIMVPNPPRLNEIVNALHKYQGDVILVGNTEILRAWRELWELGFLVEPTS
ASIYAALEKIKNQLSGKKVLLVLTGSGLKNIPDI

Sequences:

>Translated_354_residues
MKWKCNHCGFEADAFSEYHWRCPRCGGPLDLVYDGKLEKTSSKNIWEKYGGTIPLKPEKTRREGNTPLVEEKIDGMTLLF
KLEYLNPGGSFKDRGSTLAIYYAYKLGFKNVIEDTSGNTGISVALYSRLYNLKTRIYMPKTAPPGKKKVIKALDAEIIEA
PTRGDATEMVLKEALTGAYYVAHTWSYFYIMGASTIAWEVLEEDVPDYVISPIGSGGLFLGLVKGFEKALEAGWITKMPR
FIGVQGYSTQPVYKAFKGVTQPGEDSSLADGIMVPNPPRLNEIVNALHKYQGDVILVGNTEILRAWRELWELGFLVEPTS
ASIYAALEKIKNQLSGKKVLLVLTGSGLKNIPDI
>Mature_354_residues
MKWKCNHCGFEADAFSEYHWRCPRCGGPLDLVYDGKLEKTSSKNIWEKYGGTIPLKPEKTRREGNTPLVEEKIDGMTLLF
KLEYLNPGGSFKDRGSTLAIYYAYKLGFKNVIEDTSGNTGISVALYSRLYNLKTRIYMPKTAPPGKKKVIKALDAEIIEA
PTRGDATEMVLKEALTGAYYVAHTWSYFYIMGASTIAWEVLEEDVPDYVISPIGSGGLFLGLVKGFEKALEAGWITKMPR
FIGVQGYSTQPVYKAFKGVTQPGEDSSLADGIMVPNPPRLNEIVNALHKYQGDVILVGNTEILRAWRELWELGFLVEPTS
ASIYAALEKIKNQLSGKKVLLVLTGSGLKNIPDI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. Does not catalyze the conversion of O-acetyl-L- homoserine into threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=307, Percent_Identity=28.0130293159609, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI295821202, Length=193, Percent_Identity=30.5699481865285, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI295821200, Length=193, Percent_Identity=30.5699481865285, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557415, Length=193, Percent_Identity=30.5699481865285, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508781, Length=274, Percent_Identity=28.1021897810219, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 39341; Mature: 39341

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWKCNHCGFEADAFSEYHWRCPRCGGPLDLVYDGKLEKTSSKNIWEKYGGTIPLKPEKT
CCEECCCCCCCHHCCCHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHH
RREGNTPLVEEKIDGMTLLFKLEYLNPGGSFKDRGSTLAIYYAYKLGFKNVIEDTSGNTG
HCCCCCCCHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEHHCHHHHHHCCCCCCC
ISVALYSRLYNLKTRIYMPKTAPPGKKKVIKALDAEIIEAPTRGDATEMVLKEALTGAYY
CHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEE
VAHTWSYFYIMGASTIAWEVLEEDVPDYVISPIGSGGLFLGLVKGFEKALEAGWITKMPR
EEEHEEEEEEECCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHCCH
FIGVQGYSTQPVYKAFKGVTQPGEDSSLADGIMVPNPPRLNEIVNALHKYQGDVILVGNT
HHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCH
EILRAWRELWELGFLVEPTSASIYAALEKIKNQLSGKKVLLVLTGSGLKNIPDI
HHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKWKCNHCGFEADAFSEYHWRCPRCGGPLDLVYDGKLEKTSSKNIWEKYGGTIPLKPEKT
CCEECCCCCCCHHCCCHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHH
RREGNTPLVEEKIDGMTLLFKLEYLNPGGSFKDRGSTLAIYYAYKLGFKNVIEDTSGNTG
HCCCCCCCHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEEHHCHHHHHHCCCCCCC
ISVALYSRLYNLKTRIYMPKTAPPGKKKVIKALDAEIIEAPTRGDATEMVLKEALTGAYY
CHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEE
VAHTWSYFYIMGASTIAWEVLEEDVPDYVISPIGSGGLFLGLVKGFEKALEAGWITKMPR
EEEHEEEEEEECCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHCCH
FIGVQGYSTQPVYKAFKGVTQPGEDSSLADGIMVPNPPRLNEIVNALHKYQGDVILVGNT
HHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCH
EILRAWRELWELGFLVEPTSASIYAALEKIKNQLSGKKVLLVLTGSGLKNIPDI
HHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]