BacMap

Definition	Desulfurococcus kamchatkensis 1221n chromosome, complete genome.
Accession	NC_011766
Length	1,365,223

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The map label for this gene is psmB2

Identifier: 218884599

GI number: 218884599

Start: 1206455

End: 1207075

Strand: Reverse

Name: psmB2

Synonym: DKAM_1288

Alternate gene names: 218884599

Gene position: 1207075-1206455 (Counterclockwise)

Preceding gene: 218884601

Following gene: 218884598

Centisome position: 88.42

GC content: 44.93

Gene sequence:

>621_bases
TTGCGAGAGGCTGTTTCGAAGACCACCACTGTAGGACTTGTTACTGGAGACTATGTTGTTCTCGCAGCGGATAAAAGAGC
CACGGCTGGACCAATGGTTTACCATAAGGCTGTTAAAAAGATTTCCAAGATAACAGATTATGCTGCGCTAACTATATCGG
GACTAGTGGCTGATGCACAGTATATCGTTGAGAACGCCAGGTATATCGCTAGGGAATACGAGATCGAGATGGGGGGTCCC
ATACCAATTAAGGCGTTAGCCTCAAGGATATCATTAATACTATCGGTTTACCTAAGATACAGCCCATTCATAGTCCAACT
ACTACTAGGAGGCAGAGATAGCACTGGTGCAAGCCTATACTACATGGATTTATACGGAAGTGTAACAAGGGAGAAGTATA
TGGCTACTGGGAGCGGTTCCCCAGTGGCATTCGGGATCCTAGAGAAAAATTATAGAAGTGATTTAAGCCTCGAGGAGGCT
AAGAAACTCGCCTTCAACGCTGTTTCATCAGCTATAATGAGGGATGGATTCAGCGGGGAAGGAGTAGATATAGTTGTAAT
AGGGCCCGGCATCTACTCTGAGGAAACAATACCATTAAAGAAAACCATCGAGTCGTCTTAA

Upstream 100 bases:

>100_bases
AGGGGGAACAAAAACGAGGGGGTGAAACAAGCTTATATAAACCTATACCTATATAAGACCTAAACCCCTTGTATCCTATC
CTAGTAGGAGGTGTGAGTTG

Downstream 100 bases:

>100_bases
AGGGTTTTTACAACCGAAACCCTAGCATTAACCAAGATTTATAAACACTTCATCCCCGCTCTAAGGGGCAGGGCATTAAG
GTGGAGGCCCTAAACGAACA

Product: Proteasome subunit

Products: NA

Alternate protein names: 20S proteasome beta subunit 2; Proteasome core protein PsmB 2

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQYIVENARYIAREYEIEMGGP
IPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLYYMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEA
KKLAFNAVSSAIMRDGFSGEGVDIVVIGPGIYSEETIPLKKTIESS

Sequences:

>Translated_206_residues
MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQYIVENARYIAREYEIEMGGP
IPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLYYMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEA
KKLAFNAVSSAIMRDGFSGEGVDIVVIGPGIYSEETIPLKKTIESS
>Mature_206_residues
MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQYIVENARYIAREYEIEMGGP
IPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLYYMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEA
KKLAFNAVSSAIMRDGFSGEGVDIVVIGPGIYSEETIPLKKTIESS

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4758970, Length=185, Percent_Identity=32.972972972973, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI73747875, Length=185, Percent_Identity=32.972972972973, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4506203, Length=200, Percent_Identity=33.5, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4506191, Length=183, Percent_Identity=34.9726775956284, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4506201, Length=187, Percent_Identity=32.620320855615, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI23110942, Length=194, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI153791216, Length=180, Percent_Identity=32.2222222222222, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI23110925, Length=180, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4506205, Length=169, Percent_Identity=29.585798816568, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI156713442, Length=184, Percent_Identity=27.7173913043478, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4506185, Length=184, Percent_Identity=27.7173913043478, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI68303563, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4506181, Length=177, Percent_Identity=29.3785310734463, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI4506193, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508493, Length=194, Percent_Identity=28.8659793814433, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17541700, Length=192, Percent_Identity=33.8541666666667, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508495, Length=182, Percent_Identity=30.2197802197802, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508499, Length=171, Percent_Identity=29.8245614035088, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25143215, Length=168, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324731, Length=196, Percent_Identity=31.6326530612245, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325360, Length=177, Percent_Identity=29.3785310734463, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321574, Length=186, Percent_Identity=26.8817204301075, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324938, Length=163, Percent_Identity=34.3558282208589, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322459, Length=181, Percent_Identity=28.7292817679558, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323547, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321692, Length=169, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584895, Length=172, Percent_Identity=36.046511627907, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24639979, Length=183, Percent_Identity=33.879781420765, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664391, Length=182, Percent_Identity=32.4175824175824, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130281, Length=175, Percent_Identity=33.1428571428571, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355573, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24652553, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24654391, Length=191, Percent_Identity=28.2722513089005, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24654389, Length=191, Percent_Identity=28.2722513089005, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573221, Length=182, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281360341, Length=188, Percent_Identity=31.3829787234043, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586406, Length=188, Percent_Identity=31.3829787234043, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586400, Length=188, Percent_Identity=31.3829787234043, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586402, Length=188, Percent_Identity=31.3829787234043, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737927, Length=176, Percent_Identity=28.9772727272727, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24653999, Length=184, Percent_Identity=31.5217391304348, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651571, Length=194, Percent_Identity=30.4123711340206, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921232, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136420, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17933602, Length=174, Percent_Identity=28.1609195402299, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB2_DESK1 (B8D683)

Other databases:

- EMBL:   CP001140
- RefSeq:   YP_002428981.1
- MEROPS:   T01.002
- GeneID:   7171347
- GenomeReviews:   CP001140_GR
- KEGG:   dka:DKAM_1288
- HOGENOM:   HBG499923
- OMA:   MAYGVLE
- ProtClustDB:   CLSK2399619
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR000243
- InterPro:   IPR001353
- PRINTS:   PR00141

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 22270; Mature: 22270

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 8-8

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQ
CCCHHHHCEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIVENARYIAREYEIEMGGPIPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLY
HHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEAKKLAFNAVSSAIMRDGFSGE
EEEHHCCHHHHHEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GVDIVVIGPGIYSEETIPLKKTIESS
CEEEEEECCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MREAVSKTTTVGLVTGDYVVLAADKRATAGPMVYHKAVKKISKITDYAALTISGLVADAQ
CCCHHHHCEEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIVENARYIAREYEIEMGGPIPIKALASRISLILSVYLRYSPFIVQLLLGGRDSTGASLY
HHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YMDLYGSVTREKYMATGSGSPVAFGILEKNYRSDLSLEEAKKLAFNAVSSAIMRDGFSGE
EEEHHCCHHHHHEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
GVDIVVIGPGIYSEETIPLKKTIESS
CEEEEEECCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA