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The map label for this gene is tyrS [H]

Identifier: 218884548

GI number: 218884548

Start: 1158318

End: 1159403

Strand: Reverse

Name: tyrS [H]

Synonym: DKAM_1237

Alternate gene names: 218884548

Gene position: 1159403-1158318 (Counterclockwise)

Preceding gene: 218884549

Following gene: 218884546

Centisome position: 84.92

GC content: 45.76

Gene sequence:

>1086_bases
ATGGATGCGGATGAAAAGGTGAAATTGGCTACACGCAATGTCCTCGAGGTAATAACAATCGAGGAGCTCAGGAAGATCTT
CGAGGATAAAGAGCGTCCAAAAGGATACCTCGGCTTCGAGCCCAGTGGATTAGTCCATGTTGGATGGCTTGTCTGGATGT
TTAAGGTCAGGGATCTCGTGAACGCCGGGGTCGACTTCTACATCCTGGAGGCAACGTGGCACGCCTACATCAATGATAAG
CTAGGTGGGGACATAGAGATGATCCGTAAGGCTGCTAGATACACGAGGATAATACTAGACGCGATAGGTGTACCTGAGAC
GAGGATTAAGTATGTTGATGCCGAAGAGCTGGCAAGTGATAAGGAGTACTGGGGATTATTATTGAAGGCGGCGAAACACA
GTAGTCTAGCGAGGGTTAAGAGGGCGCTTACTATAATGGGTCGTAAGATGGATGAGGGAGAGACAGATTTCTCGAAGCTG
ATATATCCATTGATGCAGGTGACAGATATATTCTACCTAGATCTTGACATAGCCCTTGGTGGAATGGATCAGAGAAAAGC
CCATATGCTGACTAGAGATATAGCTGAGAAACTAGGACGCAGAAAACCAGTTGCACTCCATACCCCGATAATCACGGGGC
TCCAGGGCCCCAGTGGGAGAATGGAGGGCAGGGAATACGATGAAATAGCCTCAGACGTTAAGATGAGTAAGAGTAAGCCT
GAGACAGCAATCTTTGTCCATGATCCACCAGAAGTCGTCGAGGAGAAAATACTTAAAGCATACTGTCCACAGAGAATCAC
AGAGTTGAACCCTGTGATAGAGTTAAATAAATACCTGTTATTCCAGCAAGAAGGCTTCAAGCTAGTGGTTGAAAGACCCG
AGAAATACGGGGGAACCATAGTGATCGAGAGTTATAATGACCTGGAAAGAATGTATGTGAAAGGCGAGATACACCCATTA
GACTTGAAGAAGGCAACAGCAAATGCATTGAATAAGCTTCTAGACCCTATAAGGAGACGAATAGAAAGTGATCCCATTGC
AAAGGAAATCTTGGAAGAATTGCTAAAGGCAAAGGTTACAAGGTAG

Upstream 100 bases:

>100_bases
GGCCTCACCCATTAGGGCTGGAAGAGGTCGATTAATTTATTAGACCGGTGATCCACAATATAAAGTAATAACTTAAGATT
AATTTAGAACCGGTGATCCC

Downstream 100 bases:

>100_bases
AATCATGGATTAGTTACTAGGGAAATTAATATCATAAGTTTCTAGCTTGTGAATCTTTAAAACCCGGCTAATTAATCACA
GTAGATAATGGGTGGGCCGG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDADEKVKLATRNVLEVITIEELRKIFEDKERPKGYLGFEPSGLVHVGWLVWMFKVRDLVNAGVDFYILEATWHAYINDK
LGGDIEMIRKAARYTRIILDAIGVPETRIKYVDAEELASDKEYWGLLLKAAKHSSLARVKRALTIMGRKMDEGETDFSKL
IYPLMQVTDIFYLDLDIALGGMDQRKAHMLTRDIAEKLGRRKPVALHTPIITGLQGPSGRMEGREYDEIASDVKMSKSKP
ETAIFVHDPPEVVEEKILKAYCPQRITELNPVIELNKYLLFQQEGFKLVVERPEKYGGTIVIESYNDLERMYVKGEIHPL
DLKKATANALNKLLDPIRRRIESDPIAKEILEELLKAKVTR

Sequences:

>Translated_361_residues
MDADEKVKLATRNVLEVITIEELRKIFEDKERPKGYLGFEPSGLVHVGWLVWMFKVRDLVNAGVDFYILEATWHAYINDK
LGGDIEMIRKAARYTRIILDAIGVPETRIKYVDAEELASDKEYWGLLLKAAKHSSLARVKRALTIMGRKMDEGETDFSKL
IYPLMQVTDIFYLDLDIALGGMDQRKAHMLTRDIAEKLGRRKPVALHTPIITGLQGPSGRMEGREYDEIASDVKMSKSKP
ETAIFVHDPPEVVEEKILKAYCPQRITELNPVIELNKYLLFQQEGFKLVVERPEKYGGTIVIESYNDLERMYVKGEIHPL
DLKKATANALNKLLDPIRRRIESDPIAKEILEELLKAKVTR
>Mature_361_residues
MDADEKVKLATRNVLEVITIEELRKIFEDKERPKGYLGFEPSGLVHVGWLVWMFKVRDLVNAGVDFYILEATWHAYINDK
LGGDIEMIRKAARYTRIILDAIGVPETRIKYVDAEELASDKEYWGLLLKAAKHSSLARVKRALTIMGRKMDEGETDFSKL
IYPLMQVTDIFYLDLDIALGGMDQRKAHMLTRDIAEKLGRRKPVALHTPIITGLQGPSGRMEGREYDEIASDVKMSKSKP
ETAIFVHDPPEVVEEKILKAYCPQRITELNPVIELNKYLLFQQEGFKLVVERPEKYGGTIVIESYNDLERMYVKGEIHPL
DLKKATANALNKLLDPIRRRIESDPIAKEILEELLKAKVTR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=349, Percent_Identity=32.6647564469914, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71992775, Length=350, Percent_Identity=27.4285714285714, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321624, Length=356, Percent_Identity=29.7752808988764, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357223, Length=352, Percent_Identity=31.5340909090909, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 41353; Mature: 41353

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADEKVKLATRNVLEVITIEELRKIFEDKERPKGYLGFEPSGLVHVGWLVWMFKVRDLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NAGVDFYILEATWHAYINDKLGGDIEMIRKAARYTRIILDAIGVPETRIKYVDAEELASD
HCCCCEEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHCC
KEYWGLLLKAAKHSSLARVKRALTIMGRKMDEGETDFSKLIYPLMQVTDIFYLDLDIALG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEHHCC
GMDQRKAHMLTRDIAEKLGRRKPVALHTPIITGLQGPSGRMEGREYDEIASDVKMSKSKP
CCCHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
ETAIFVHDPPEVVEEKILKAYCPQRITELNPVIELNKYLLFQQEGFKLVVERPEKYGGTI
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCEEEEECHHHCCCEE
VIESYNDLERMYVKGEIHPLDLKKATANALNKLLDPIRRRIESDPIAKEILEELLKAKVT
EEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure
MDADEKVKLATRNVLEVITIEELRKIFEDKERPKGYLGFEPSGLVHVGWLVWMFKVRDLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NAGVDFYILEATWHAYINDKLGGDIEMIRKAARYTRIILDAIGVPETRIKYVDAEELASD
HCCCCEEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHCC
KEYWGLLLKAAKHSSLARVKRALTIMGRKMDEGETDFSKLIYPLMQVTDIFYLDLDIALG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEHHCC
GMDQRKAHMLTRDIAEKLGRRKPVALHTPIITGLQGPSGRMEGREYDEIASDVKMSKSKP
CCCHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
ETAIFVHDPPEVVEEKILKAYCPQRITELNPVIELNKYLLFQQEGFKLVVERPEKYGGTI
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCEEEEECHHHCCCEE
VIESYNDLERMYVKGEIHPLDLKKATANALNKLLDPIRRRIESDPIAKEILEELLKAKVT
EEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]