Click here to switch to the map view.

The map label for this gene is eif6 [H]

Identifier: 218884421

GI number: 218884421

Start: 1048235

End: 1048909

Strand: Reverse

Name: eif6 [H]

Synonym: DKAM_1110

Alternate gene names: 218884421

Gene position: 1048909-1048235 (Counterclockwise)

Preceding gene: 218884422

Following gene: 218884420

Centisome position: 76.83

GC content: 45.63

Gene sequence:

>675_bases
ATGAGTTTCTTCGGTAACTCGAATATAGGGGTCTACGCGTATACGAATAGTAAGATGCTGGTTCTTCCCCCTGGGATAGG
TAGTAGTGATCAAAGGGAAATGATCGAGGTATTAAAGGTTAAGGGAATAATCGAGTCCAGGATAGCTGGCACAGTGTTGA
ATGGTGTCTTCATAGCTGGGAACGATAGCGCGATCATTCTGCCGAGGATAATATTCGATGATGAGTTGGGGTCTCTTAGA
AAACAGATTAGGGAGCAGGGTATAGATATCGTGCACTACGTCTCGGGCTCGAGGTTCACTGCGCTCGGGAACCTACTAGT
ATGTAATAACAAGGGGTGTATTGCAAGCACGTTGTTTGAGAGAGATGTTGTAAGGGATTTAAGTAGTGTCCTCGGTGTGG
AAATAGTTCAGTTACCCTTATTAAACCTGGAAATACCGGGTAGCCTCCTCGTAGTAAATGACCAGGGTGGGGTGGTACAC
CCTGATGCTAGTGATGGGGATTTAAAAACCATAGAGGAAATCCTAAAGGTAAGGGTTGAAAGGGCAACCGTGAACGCTGG
AATACCGTTTGTGAAGAGTGGTTTATTAGCCAATAACCACGGTATAATTGTAGGAGGCAATACAACGGGTCCCGAGATAC
TTAGGATTAGAAAGGGGTTTGGAGGTGGGGAGTAG

Upstream 100 bases:

>100_bases
AAGTAGCTTGAATACTTAAAGAACTATTTAATCCTCTAGCTATAAATATATTTCTCAGTGTTTCAGGAAGGGTCGGTGGT
TTTAATTGGAGATTACCAGG

Downstream 100 bases:

>100_bases
TGGAGGTTAAAACATATAGGGTTACAGGCTACATGTTGATAAGCCATGATAGATACCCTACTTGGCAGAGGTTCACGAAG
GATGTAAGAGGTGTAAGTGA

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6 [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSFFGNSNIGVYAYTNSKMLVLPPGIGSSDQREMIEVLKVKGIIESRIAGTVLNGVFIAGNDSAIILPRIIFDDELGSLR
KQIREQGIDIVHYVSGSRFTALGNLLVCNNKGCIASTLFERDVVRDLSSVLGVEIVQLPLLNLEIPGSLLVVNDQGGVVH
PDASDGDLKTIEEILKVRVERATVNAGIPFVKSGLLANNHGIIVGGNTTGPEILRIRKGFGGGE

Sequences:

>Translated_224_residues
MSFFGNSNIGVYAYTNSKMLVLPPGIGSSDQREMIEVLKVKGIIESRIAGTVLNGVFIAGNDSAIILPRIIFDDELGSLR
KQIREQGIDIVHYVSGSRFTALGNLLVCNNKGCIASTLFERDVVRDLSSVLGVEIVQLPLLNLEIPGSLLVVNDQGGVVH
PDASDGDLKTIEEILKVRVERATVNAGIPFVKSGLLANNHGIIVGGNTTGPEILRIRKGFGGGE
>Mature_223_residues
SFFGNSNIGVYAYTNSKMLVLPPGIGSSDQREMIEVLKVKGIIESRIAGTVLNGVFIAGNDSAIILPRIIFDDELGSLRK
QIREQGIDIVHYVSGSRFTALGNLLVCNNKGCIASTLFERDVVRDLSSVLGVEIVQLPLLNLEIPGSLLVVNDQGGVVHP
DASDGDLKTIEEILKVRVERATVNAGIPFVKSGLLANNHGIIVGGNTTGPEILRIRKGFGGGE

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex [H]

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family [H]

Homologues:

Organism=Homo sapiens, GI4504771, Length=228, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI31563378, Length=228, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17506075, Length=226, Percent_Identity=24.7787610619469, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325273, Length=220, Percent_Identity=31.8181818181818, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21492634, Length=221, Percent_Identity=28.0542986425339, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002769 [H]

Pfam domain/function: PF01912 eIF-6 [H]

EC number: NA

Molecular weight: Translated: 23906; Mature: 23775

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFGNSNIGVYAYTNSKMLVLPPGIGSSDQREMIEVLKVKGIIESRIAGTVLNGVFIAG
CCCCCCCCEEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
NDSAIILPRIIFDDELGSLRKQIREQGIDIVHYVSGSRFTALGNLLVCNNKGCIASTLFE
CCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCEEEEECCEEEECCCCCHHHHHHH
RDVVRDLSSVLGVEIVQLPLLNLEIPGSLLVVNDQGGVVHPDASDGDLKTIEEILKVRVE
HHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHH
RATVNAGIPFVKSGLLANNHGIIVGGNTTGPEILRIRKGFGGGE
HHEECCCCCHHHCCEEECCCEEEEECCCCCHHHEEEECCCCCCC
>Mature Secondary Structure 
SFFGNSNIGVYAYTNSKMLVLPPGIGSSDQREMIEVLKVKGIIESRIAGTVLNGVFIAG
CCCCCCCEEEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
NDSAIILPRIIFDDELGSLRKQIREQGIDIVHYVSGSRFTALGNLLVCNNKGCIASTLFE
CCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCEEEEECCEEEECCCCCHHHHHHH
RDVVRDLSSVLGVEIVQLPLLNLEIPGSLLVVNDQGGVVHPDASDGDLKTIEEILKVRVE
HHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHH
RATVNAGIPFVKSGLLANNHGIIVGGNTTGPEILRIRKGFGGGE
HHEECCCCCHHHCCEEECCCEEEEECCCCCHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA