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The map label for this gene is nuoD [H]

Identifier: 218884265

GI number: 218884265

Start: 900978

End: 902099

Strand: Reverse

Name: nuoD [H]

Synonym: DKAM_0954

Alternate gene names: 218884265

Gene position: 902099-900978 (Counterclockwise)

Preceding gene: 218884266

Following gene: 218884264

Centisome position: 66.08

GC content: 45.81

Gene sequence:

>1122_bases
ATGGAGGGTATAAGTATGGCAGGTAAAGGTAGACTCGTAGAGATCTACTTTGGTCCGCAGCACCCCGGTGCACCGGGTAA
TATAGCATTTAAACTAACACTTGACGGTGAAAGAGTAGTCAACGTGGAGACTATACCTGGCTTCCTTCACCGTGGATTCG
AGAAAATGATGGAGAATAGAACCTGGGAGATGAATGTTGTTCTAAGCTACAGATTCTGCGTTGAAGATCCCGATCCCCTT
GAAATAGCCTACGCTATGGCTGTTGAGAAAATACATGGGGTTGAAATACCTGAGAACGCTAAATATATCCGCATGATACA
AGCAGAGTTCTCCAGGATTGCATCCCATCTCTTCTGGTCTCACTTCATAGGTGGAAGCACCGGATTGAGGACACCTGCTT
ACTGGGCTCTAGTAGCGCGTGAAGAGATATTAAAGTGGTTTGCCAGGTTCGCTGGACACAGGGTCTACCATAATATCAGT
GTACCCGGTGGAGTAAGATATCCACTTCCAAAATCCTTTGTAGAAGATACCCTTAGATTAACGAACTTCGTCGAGGAGAA
AGTGAGAGATGTTGAGGCAGCCCTTTTAAAGAATAATATATTCCGTGATAGAACTAGAGGCGTTGGCAGGTTAAGCAGTA
AGGAGGCATTAGAGCTAGGGGTCACAGGACCGGTGCTAAGGGCAGCCGGGTTACCTTACGACCTGAGAAAGGTAACACCA
TATCTGAACTACGACAAGATACAGTTTGAGGTACCCATAGTACAGAATGGCGATGCATATGATAGAAGTGTCCTGAGGTT
CCGTGAGATATATGAGAGTCTGAAAATAATACGTGAGAGCGTTAAAAGAATTGATCCCGAGGGAGGTTTACGCGTTAAAC
TACCTTTAACTGCTCCACCAGGCGAGGGCATTGCAAGGGTCGAATCAGCTAGAGGAGAATATATGATACACATTATAAGC
ACCGGGGGGAGAAAACCCTACAGGGTCAGGTTGAAGAGTATGTCGTTACCATTGATGACCACCGTGGTAGAATATATAGT
GAAACGCGACGAGGTCACAATAGCAGACTTTCCCATTCTACTCGCGTCACTAGATCCATGTGCACCAGATATTGACAGGT
GA

Upstream 100 bases:

>100_bases
AATCCCGAATTAAAGAAGTGGATCCTAGACGGTAACTGGGAGGGGCCGCCCCCATTAAGGAAAGATGTTGACACAGCTGG
TTTCGTTATGAAAACAATGT

Downstream 100 bases:

>100_bases
TAGTGAATGGTTGTAGCCTCGATCTCAAACTCGCTTAAATACCTTTTAAGGAAGCCGTATACGAGGCAGGTTCCCAGAAT
AGATAAACCGTTTAAGACTC

Product: NADH-ubiquinone oxidoreductase, chain 49 kDa

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MEGISMAGKGRLVEIYFGPQHPGAPGNIAFKLTLDGERVVNVETIPGFLHRGFEKMMENRTWEMNVVLSYRFCVEDPDPL
EIAYAMAVEKIHGVEIPENAKYIRMIQAEFSRIASHLFWSHFIGGSTGLRTPAYWALVAREEILKWFARFAGHRVYHNIS
VPGGVRYPLPKSFVEDTLRLTNFVEEKVRDVEAALLKNNIFRDRTRGVGRLSSKEALELGVTGPVLRAAGLPYDLRKVTP
YLNYDKIQFEVPIVQNGDAYDRSVLRFREIYESLKIIRESVKRIDPEGGLRVKLPLTAPPGEGIARVESARGEYMIHIIS
TGGRKPYRVRLKSMSLPLMTTVVEYIVKRDEVTIADFPILLASLDPCAPDIDR

Sequences:

>Translated_373_residues
MEGISMAGKGRLVEIYFGPQHPGAPGNIAFKLTLDGERVVNVETIPGFLHRGFEKMMENRTWEMNVVLSYRFCVEDPDPL
EIAYAMAVEKIHGVEIPENAKYIRMIQAEFSRIASHLFWSHFIGGSTGLRTPAYWALVAREEILKWFARFAGHRVYHNIS
VPGGVRYPLPKSFVEDTLRLTNFVEEKVRDVEAALLKNNIFRDRTRGVGRLSSKEALELGVTGPVLRAAGLPYDLRKVTP
YLNYDKIQFEVPIVQNGDAYDRSVLRFREIYESLKIIRESVKRIDPEGGLRVKLPLTAPPGEGIARVESARGEYMIHIIS
TGGRKPYRVRLKSMSLPLMTTVVEYIVKRDEVTIADFPILLASLDPCAPDIDR
>Mature_373_residues
MEGISMAGKGRLVEIYFGPQHPGAPGNIAFKLTLDGERVVNVETIPGFLHRGFEKMMENRTWEMNVVLSYRFCVEDPDPL
EIAYAMAVEKIHGVEIPENAKYIRMIQAEFSRIASHLFWSHFIGGSTGLRTPAYWALVAREEILKWFARFAGHRVYHNIS
VPGGVRYPLPKSFVEDTLRLTNFVEEKVRDVEAALLKNNIFRDRTRGVGRLSSKEALELGVTGPVLRAAGLPYDLRKVTP
YLNYDKIQFEVPIVQNGDAYDRSVLRFREIYESLKIIRESVKRIDPEGGLRVKLPLTAPPGEGIARVESARGEYMIHIIS
TGGRKPYRVRLKSMSLPLMTTVVEYIVKRDEVTIADFPILLASLDPCAPDIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260898743, Length=347, Percent_Identity=30.5475504322767, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4758786, Length=347, Percent_Identity=30.5475504322767, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=29.4871794871795, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1789076, Length=377, Percent_Identity=28.6472148541114, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788832, Length=361, Percent_Identity=27.7008310249307, Blast_Score=118, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=384, Percent_Identity=29.1666666666667, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17555284, Length=384, Percent_Identity=28.125, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221459469, Length=392, Percent_Identity=34.1836734693878, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24638644, Length=390, Percent_Identity=31.5384615384615, Blast_Score=204, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 42247; Mature: 42247

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGISMAGKGRLVEIYFGPQHPGAPGNIAFKLTLDGERVVNVETIPGFLHRGFEKMMENR
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCC
TWEMNVVLSYRFCVEDPDPLEIAYAMAVEKIHGVEIPENAKYIRMIQAEFSRIASHLFWS
CEEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HFIGGSTGLRTPAYWALVAREEILKWFARFAGHRVYHNISVPGGVRYPLPKSFVEDTLRL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
TNFVEEKVRDVEAALLKNNIFRDRTRGVGRLSSKEALELGVTGPVLRAAGLPYDLRKVTP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCHHHHHCCCCHHHHHHCC
YLNYDKIQFEVPIVQNGDAYDRSVLRFREIYESLKIIRESVKRIDPEGGLRVKLPLTAPP
CCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GEGIARVESARGEYMIHIISTGGRKPYRVRLKSMSLPLMTTVVEYIVKRDEVTIADFPIL
CCCHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHH
LASLDPCAPDIDR
HHCCCCCCCCCCC
>Mature Secondary Structure
MEGISMAGKGRLVEIYFGPQHPGAPGNIAFKLTLDGERVVNVETIPGFLHRGFEKMMENR
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCC
TWEMNVVLSYRFCVEDPDPLEIAYAMAVEKIHGVEIPENAKYIRMIQAEFSRIASHLFWS
CEEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HFIGGSTGLRTPAYWALVAREEILKWFARFAGHRVYHNISVPGGVRYPLPKSFVEDTLRL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
TNFVEEKVRDVEAALLKNNIFRDRTRGVGRLSSKEALELGVTGPVLRAAGLPYDLRKVTP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCHHHHHCCCCHHHHHHCC
YLNYDKIQFEVPIVQNGDAYDRSVLRFREIYESLKIIRESVKRIDPEGGLRVKLPLTAPP
CCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GEGIARVESARGEYMIHIISTGGRKPYRVRLKSMSLPLMTTVVEYIVKRDEVTIADFPIL
CCCHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHHHH
LASLDPCAPDIDR
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA