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The map label for this gene is adk [H]

Identifier: 218884219

GI number: 218884219

Start: 862364

End: 863143

Strand: Reverse

Name: adk [H]

Synonym: DKAM_0908

Alternate gene names: 218884219

Gene position: 863143-862364 (Counterclockwise)

Preceding gene: 218884220

Following gene: 218884218

Centisome position: 63.22

GC content: 45.0

Gene sequence:

>780_bases
GTGATCCTAGGTATAAGGCATAGTTTTCACTCTCAGCCAGCATTCTCCATAATAATTAAATTACCGAAGATGAATCAATA
CTTAATGAGGTGGCTTTTAGTGAAGATAGTCTTAATAGGCGCCCCTGGGGCAGGTAAGGGAACCTACGCGCAGATACTAA
GGGAGAAGTACTGTATTCCCCACATTTCAACCGGCGATATATTCAGGGAGGAAATAGCTAGAGACACCGAGCTGGGACGA
GTGGTTAAATCCTATATAGAGAAGGGGTTACTGGTTCCAGACGAGATCGTTATAGAAGTTGTAAGCAAGAGGCTGAAGCA
ACCCGATGCATTAAGAGGCTTCATCCTAGACGGATTCCCGAGAACCCTAGAGCAGGCCAAAGCCCTCGATAAAATAGTGG
ATGTCGACGCCGTGGTGCATCTCGCTGTCTCGGAAGAAGTGGCTGTAAGGAGATTAAGCGGGCGGAGAATATGTCCAGTA
TGCAATAGAGTATATAATATATACTATGAGCCGAAGCCCAGGGAGGATGAGAAATGCGATTACGACGGAGCACAATTGAT
CAAGCGCCCAGATGACGAGCCAGAGGTAGTTAGAAACAGATATAGAGTGTTCTATGAGACGTTTAAACCAATAATCGAGT
ATTACAGGGTAAGTAGTAAGCTTATTGAAGTAGATTCAAACAAGTCTATCAAGGAGGTATTCCCGGTGCTGGAGGAGGCC
TTAAGGAGGAATAAGATACTCCAGCTACAACCATGCAAAGAAGATGTTAGAGTAGGGTAG

Upstream 100 bases:

>100_bases
GAGGTTAACGCATTCTATATGAAGAGGCCTGGCCCCCATGGGTCGAGAGCGGTCTCGAAATACCATGCGTTCCAGAAACT
ATTGAACTGGCTCGGTATAA

Downstream 100 bases:

>100_bases
TGTTAATGCGTAGGGAGAAGACTGTTGAATACGTTAGAAGTCTCGTCTTGAAACTCTACGATAACCGGGATTACTATTTC
TACGGCGATGAATTGAATAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MILGIRHSFHSQPAFSIIIKLPKMNQYLMRWLLVKIVLIGAPGAGKGTYAQILREKYCIPHISTGDIFREEIARDTELGR
VVKSYIEKGLLVPDEIVIEVVSKRLKQPDALRGFILDGFPRTLEQAKALDKIVDVDAVVHLAVSEEVAVRRLSGRRICPV
CNRVYNIYYEPKPREDEKCDYDGAQLIKRPDDEPEVVRNRYRVFYETFKPIIEYYRVSSKLIEVDSNKSIKEVFPVLEEA
LRRNKILQLQPCKEDVRVG

Sequences:

>Translated_259_residues
MILGIRHSFHSQPAFSIIIKLPKMNQYLMRWLLVKIVLIGAPGAGKGTYAQILREKYCIPHISTGDIFREEIARDTELGR
VVKSYIEKGLLVPDEIVIEVVSKRLKQPDALRGFILDGFPRTLEQAKALDKIVDVDAVVHLAVSEEVAVRRLSGRRICPV
CNRVYNIYYEPKPREDEKCDYDGAQLIKRPDDEPEVVRNRYRVFYETFKPIIEYYRVSSKLIEVDSNKSIKEVFPVLEEA
LRRNKILQLQPCKEDVRVG
>Mature_259_residues
MILGIRHSFHSQPAFSIIIKLPKMNQYLMRWLLVKIVLIGAPGAGKGTYAQILREKYCIPHISTGDIFREEIARDTELGR
VVKSYIEKGLLVPDEIVIEVVSKRLKQPDALRGFILDGFPRTLEQAKALDKIVDVDAVVHLAVSEEVAVRRLSGRRICPV
CNRVYNIYYEPKPREDEKCDYDGAQLIKRPDDEPEVVRNRYRVFYETFKPIIEYYRVSSKLIEVDSNKSIKEVFPVLEEA
LRRNKILQLQPCKEDVRVG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=36.7441860465116, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=36.7441860465116, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=37.9310344827586, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI310110345, Length=218, Percent_Identity=38.9908256880734, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI53832003, Length=218, Percent_Identity=38.9908256880734, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI8051579, Length=218, Percent_Identity=38.9908256880734, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI53832001, Length=218, Percent_Identity=38.9908256880734, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=29.1866028708134, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI7706497, Length=238, Percent_Identity=29.8319327731092, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI28144897, Length=203, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI28144899, Length=203, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4502011, Length=201, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=42.0560747663551, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=36.0975609756098, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=34.2592592592593, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=27.0935960591133, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=28.9855072463768, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=200, Percent_Identity=27, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=36.231884057971, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6321018, Length=191, Percent_Identity=37.17277486911, Blast_Score=121, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=238, Percent_Identity=28.1512605042017, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI22026816, Length=222, Percent_Identity=36.036036036036, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17737899, Length=206, Percent_Identity=39.8058252427184, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24645822, Length=206, Percent_Identity=39.8058252427184, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI221459597, Length=241, Percent_Identity=26.5560165975104, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21356893, Length=241, Percent_Identity=26.5560165975104, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17647141, Length=201, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24663208, Length=201, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 29912; Mature: 29912

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGIRHSFHSQPAFSIIIKLPKMNQYLMRWLLVKIVLIGAPGAGKGTYAQILREKYCIP
CEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
HISTGDIFREEIARDTELGRVVKSYIEKGLLVPDEIVIEVVSKRLKQPDALRGFILDGFP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCH
RTLEQAKALDKIVDVDAVVHLAVSEEVAVRRLSGRRICPVCNRVYNIYYEPKPREDEKCD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCCCC
YDGAQLIKRPDDEPEVVRNRYRVFYETFKPIIEYYRVSSKLIEVDSNKSIKEVFPVLEEA
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
LRRNKILQLQPCKEDVRVG
HHHCCCEEECCCHHCCCCC
>Mature Secondary Structure
MILGIRHSFHSQPAFSIIIKLPKMNQYLMRWLLVKIVLIGAPGAGKGTYAQILREKYCIP
CEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
HISTGDIFREEIARDTELGRVVKSYIEKGLLVPDEIVIEVVSKRLKQPDALRGFILDGFP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCH
RTLEQAKALDKIVDVDAVVHLAVSEEVAVRRLSGRRICPVCNRVYNIYYEPKPREDEKCD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCCCC
YDGAQLIKRPDDEPEVVRNRYRVFYETFKPIIEYYRVSSKLIEVDSNKSIKEVFPVLEEA
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
LRRNKILQLQPCKEDVRVG
HHHCCCEEECCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA