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The map label for this gene is yeaE [H]

Identifier: 218884216

GI number: 218884216

Start: 860702

End: 861505

Strand: Direct

Name: yeaE [H]

Synonym: DKAM_0905

Alternate gene names: 218884216

Gene position: 860702-861505 (Clockwise)

Preceding gene: 218884215

Following gene: 218884217

Centisome position: 63.04

GC content: 44.28

Gene sequence:

>804_bases
ATGTATGAGTTCAAGGAGTGGAAGGTAATCGGGTCCGATAAAGTCTCAGCAATAGGGCTCGGCACATATGGTATCAAGAG
TTATGATAAGGCGTTTGACGCGTTCATCTATGCATTAACCCATGGCATAAACCTGGTTGACACTGCTGAAATGTATGATG
GTGGGAGAGCTGAGGAGTTCATTGGAAGAGTGGTTAAAGAGGTTGGACGGGACAGCGTATTCATAACGACCAAGATGCTA
CCAAATAGACTCGATGACAAGGAGAAGATTATTAGGGCGGCTGAGGAGGCTTTAAGGAGGCTTGGTGTACCATATGTAGA
CCTCTACTTAATCCACTGGCCCAACGAAAGCCTCCCGATAAGTGTGCAAGTAAGAAACTTCGAGGTGCTCGCTGAGAAAG
GTTTAACCAGGTATATAGGGGTAAGTAATTTCGAACCAGCCATGCTGCGAGAAGCCATAGAGGCTACAAGCAAGCACAAG
ATAGTTGCAAACCAGGTTCACTACAGTGTATTCAACAGGCACTATGTTGAGAAAGAACTCCTACCCTACTGTATTGAGAA
GATAGCTCTCCAAGCATATACCCCTCTTGAAAGAGGGAACGTAGTGATAAATAACGTCATAAAGAAAATGGCTGAGAAAT
ATAGTAAAACACCTATACAGGTGGCATTGAACTACCTGGTGAGCCATATGAATGTTATAGCCGTGCCTAAGACAGAGAAT
ATAGAGCATGTAAAGGAAATACTGGGCTCAATAGGCTGGTGGATGAGTATCGATGACCTTGAATACCTGAGAAAACACGC
CTAG

Upstream 100 bases:

>100_bases
AGATCAGGTATGCCTTCAGCAGTAAACTACCTGCATGCATTTCTCTAAACTTAATTAGTTTCCACTACGTAATAAAAAAT
GTACTATTAAGGGATGCATC

Downstream 100 bases:

>100_bases
TTATCGAGGCAAGCCCTCCACGTCTTTTAGGCGGACTCCTGCCGGTATAGTGGATAAGGAATAAAATAGGGTTTACATAA
ATCTTCAACCCGATGGTGAC

Product: Putative oxidoreductase, aldo/keto reductase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MYEFKEWKVIGSDKVSAIGLGTYGIKSYDKAFDAFIYALTHGINLVDTAEMYDGGRAEEFIGRVVKEVGRDSVFITTKML
PNRLDDKEKIIRAAEEALRRLGVPYVDLYLIHWPNESLPISVQVRNFEVLAEKGLTRYIGVSNFEPAMLREAIEATSKHK
IVANQVHYSVFNRHYVEKELLPYCIEKIALQAYTPLERGNVVINNVIKKMAEKYSKTPIQVALNYLVSHMNVIAVPKTEN
IEHVKEILGSIGWWMSIDDLEYLRKHA

Sequences:

>Translated_267_residues
MYEFKEWKVIGSDKVSAIGLGTYGIKSYDKAFDAFIYALTHGINLVDTAEMYDGGRAEEFIGRVVKEVGRDSVFITTKML
PNRLDDKEKIIRAAEEALRRLGVPYVDLYLIHWPNESLPISVQVRNFEVLAEKGLTRYIGVSNFEPAMLREAIEATSKHK
IVANQVHYSVFNRHYVEKELLPYCIEKIALQAYTPLERGNVVINNVIKKMAEKYSKTPIQVALNYLVSHMNVIAVPKTEN
IEHVKEILGSIGWWMSIDDLEYLRKHA
>Mature_267_residues
MYEFKEWKVIGSDKVSAIGLGTYGIKSYDKAFDAFIYALTHGINLVDTAEMYDGGRAEEFIGRVVKEVGRDSVFITTKML
PNRLDDKEKIIRAAEEALRRLGVPYVDLYLIHWPNESLPISVQVRNFEVLAEKGLTRYIGVSNFEPAMLREAIEATSKHK
IVANQVHYSVFNRHYVEKELLPYCIEKIALQAYTPLERGNVVINNVIKKMAEKYSKTPIQVALNYLVSHMNVIAVPKTEN
IEHVKEILGSIGWWMSIDDLEYLRKHA

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=267, Percent_Identity=28.4644194756554, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI27436969, Length=205, Percent_Identity=31.219512195122, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4504825, Length=205, Percent_Identity=31.219512195122, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI27436971, Length=203, Percent_Identity=32.512315270936, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI27436964, Length=203, Percent_Identity=31.5270935960591, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI27436966, Length=203, Percent_Identity=31.5270935960591, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI27436962, Length=203, Percent_Identity=31.5270935960591, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI45446745, Length=274, Percent_Identity=27.7372262773723, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4503285, Length=274, Percent_Identity=27.7372262773723, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI310109920, Length=271, Percent_Identity=28.0442804428044, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI5453543, Length=271, Percent_Identity=28.0442804428044, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI24497577, Length=264, Percent_Identity=26.8939393939394, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI5174391, Length=264, Percent_Identity=26.8939393939394, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI24497583, Length=285, Percent_Identity=25.9649122807018, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI24497585, Length=289, Percent_Identity=24.2214532871972, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=25.8389261744966, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI300116273, Length=276, Percent_Identity=26.4492753623188, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788081, Length=246, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786400, Length=216, Percent_Identity=34.2592592592593, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87081735, Length=290, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788070, Length=215, Percent_Identity=32.093023255814, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87082198, Length=235, Percent_Identity=29.3617021276596, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789199, Length=206, Percent_Identity=30.5825242718447, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789375, Length=186, Percent_Identity=27.9569892473118, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561300, Length=254, Percent_Identity=32.6771653543307, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17552492, Length=252, Percent_Identity=31.3492063492063, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71998625, Length=259, Percent_Identity=30.8880308880309, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17564128, Length=291, Percent_Identity=26.1168384879725, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17561298, Length=280, Percent_Identity=30, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=30.4498269896194, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538386, Length=278, Percent_Identity=26.978417266187, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562292, Length=270, Percent_Identity=28.5185185185185, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550248, Length=286, Percent_Identity=27.972027972028, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324694, Length=265, Percent_Identity=30.9433962264151, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320576, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322556, Length=271, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320079, Length=256, Percent_Identity=26.953125, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657054, Length=282, Percent_Identity=29.4326241134752, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356425, Length=282, Percent_Identity=28.7234042553192, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129731, Length=282, Percent_Identity=29.7872340425532, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24663317, Length=282, Percent_Identity=28.7234042553192, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646155, Length=137, Percent_Identity=35.7664233576642, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30568; Mature: 30568

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEFKEWKVIGSDKVSAIGLGTYGIKSYDKAFDAFIYALTHGINLVDTAEMYDGGRAEEF
CCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCHHHH
IGRVVKEVGRDSVFITTKMLPNRLDDKEKIIRAAEEALRRLGVPYVDLYLIHWPNESLPI
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCE
SVQVRNFEVLAEKGLTRYIGVSNFEPAMLREAIEATSKHKIVANQVHYSVFNRHYVEKEL
EEEECCHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LPYCIEKIALQAYTPLERGNVVINNVIKKMAEKYSKTPIQVALNYLVSHMNVIAVPKTEN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCC
IEHVKEILGSIGWWMSIDDLEYLRKHA
HHHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MYEFKEWKVIGSDKVSAIGLGTYGIKSYDKAFDAFIYALTHGINLVDTAEMYDGGRAEEF
CCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCHHHH
IGRVVKEVGRDSVFITTKMLPNRLDDKEKIIRAAEEALRRLGVPYVDLYLIHWPNESLPI
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCE
SVQVRNFEVLAEKGLTRYIGVSNFEPAMLREAIEATSKHKIVANQVHYSVFNRHYVEKEL
EEEECCHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LPYCIEKIALQAYTPLERGNVVINNVIKKMAEKYSKTPIQVALNYLVSHMNVIAVPKTEN
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCC
IEHVKEILGSIGWWMSIDDLEYLRKHA
HHHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]