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The map label for this gene is aIF-2BII [H]

Identifier: 218883771

GI number: 218883771

Start: 428962

End: 429897

Strand: Reverse

Name: aIF-2BII [H]

Synonym: DKAM_0460

Alternate gene names: 218883771

Gene position: 429897-428962 (Counterclockwise)

Preceding gene: 218883772

Following gene: 218883770

Centisome position: 31.49

GC content: 49.57

Gene sequence:

>936_bases
ATGTCTGAGCTTGAAAGACATGGGTTTACCCGGAGGGCAACTGGATCCGAGCTATTATTTCAAATAGCCTCGGCTTTAAA
GGAGTCGAGTAGTGATGTGAAGTCGTTTGCAAGAACCTTTACAAGGATCTATGAGGATATAATCAATGAGAGGCCTAGCT
CGATGGCGTCCATCAATGCTTTAAGGATGATCGGTGAGTACTTCCTGGAGAACGGGGTTAACGGGATCCGGGACTACATT
GATGGTATTGCCGCCAGGTACGAGGAGAGCATCATGAGAGCGGCTGAGGTGGCGGCTAAAAGAGTCGTTGAGGGGGATGC
GTTGATCACTAATAGTAATAGCCTAGCTATTCGAAGACTCTTCAAGACCCTAAGCGATAGCAAGGTCAAGGTAAAGGTAT
ATGTTACTGAGTCCAGGCCGGGCCTCGAGGGATTGTTAATGGCTGAGTACCTGGAGAAACTGGGCTTCGAGGTCTACTTG
ATCGTTGACTCAGCTGCCCGCTTCTTCATGAAGAACATTGATAAGGCGGTGTTGGGGGCTGAAGCAGTTGCTGTAAACGG
CGCTGTAGTGAGTAAGATTGGGACAAGCGTTATCGCCCTGGACGCACATGAAGCCAGGGTAAGGGTATTCGTTGTAGCAC
CTACATTGAAGTTTAGTATTGAGACCATATACGGGGAGTTAATTAAGTTGCCTGAGGGAGACTGGCGTCTCCTAATGGAT
GAGGACACTAGGAGAACCCTCCCAGAGAACTATAGAGCCTTCGCGCCCCTCTACGATGTAACTCCAGCCGAGTACGTGGA
CGGCATAGCAACCGAGAAAGGATTATTTGCTCCGCAGGCGATACCGATAGTCATCAGGGAGGTCTACGGAGGCTTTCCAC
CTCTTGTAAAGCCCCTTGAGAAAATAGCGATGGAGGTAAGGAGGTACCTGGAATGA

Upstream 100 bases:

>100_bases
ACCTTACTCTAATACCAGTGAATTCAATGACTTTATTGATCTCCTGGTAGAGTTTATTACCTCCTATCAATAACTAGTCT
TCTCTAAAAGGTGCTGGGTA

Downstream 100 bases:

>100_bases
GCGATGTTAGTATACCTCCAAAGGTCCTTGAGATAGCTGATGGAATAAAGACGATGAGGATCCGGGGAGCTGGTAAGATC
GGGCGGGCAGCAGCCGAAGC

Product: translation initiation factor eIF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSELERHGFTRRATGSELLFQIASALKESSSDVKSFARTFTRIYEDIINERPSSMASINALRMIGEYFLENGVNGIRDYI
DGIAARYEESIMRAAEVAAKRVVEGDALITNSNSLAIRRLFKTLSDSKVKVKVYVTESRPGLEGLLMAEYLEKLGFEVYL
IVDSAARFFMKNIDKAVLGAEAVAVNGAVVSKIGTSVIALDAHEARVRVFVVAPTLKFSIETIYGELIKLPEGDWRLLMD
EDTRRTLPENYRAFAPLYDVTPAEYVDGIATEKGLFAPQAIPIVIREVYGGFPPLVKPLEKIAMEVRRYLE

Sequences:

>Translated_311_residues
MSELERHGFTRRATGSELLFQIASALKESSSDVKSFARTFTRIYEDIINERPSSMASINALRMIGEYFLENGVNGIRDYI
DGIAARYEESIMRAAEVAAKRVVEGDALITNSNSLAIRRLFKTLSDSKVKVKVYVTESRPGLEGLLMAEYLEKLGFEVYL
IVDSAARFFMKNIDKAVLGAEAVAVNGAVVSKIGTSVIALDAHEARVRVFVVAPTLKFSIETIYGELIKLPEGDWRLLMD
EDTRRTLPENYRAFAPLYDVTPAEYVDGIATEKGLFAPQAIPIVIREVYGGFPPLVKPLEKIAMEVRRYLE
>Mature_310_residues
SELERHGFTRRATGSELLFQIASALKESSSDVKSFARTFTRIYEDIINERPSSMASINALRMIGEYFLENGVNGIRDYID
GIAARYEESIMRAAEVAAKRVVEGDALITNSNSLAIRRLFKTLSDSKVKVKVYVTESRPGLEGLLMAEYLEKLGFEVYLI
VDSAARFFMKNIDKAVLGAEAVAVNGAVVSKIGTSVIALDAHEARVRVFVVAPTLKFSIETIYGELIKLPEGDWRLLMDE
DTRRTLPENYRAFAPLYDVTPAEYVDGIATEKGLFAPQAIPIVIREVYGGFPPLVKPLEKIAMEVRRYLE

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI78000156, Length=259, Percent_Identity=28.1853281853282, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI78000158, Length=259, Percent_Identity=28.1853281853282, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI187607323, Length=259, Percent_Identity=28.1853281853282, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4503503, Length=193, Percent_Identity=27.4611398963731, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557123, Length=285, Percent_Identity=27.0175438596491, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322878, Length=218, Percent_Identity=27.9816513761468, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321520, Length=149, Percent_Identity=30.8724832214765, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281364091, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24659399, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24659407, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922816, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358605, Length=189, Percent_Identity=30.6878306878307, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357667, Length=149, Percent_Identity=35.5704697986577, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651647, Length=149, Percent_Identity=35.5704697986577, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 34703; Mature: 34572

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELERHGFTRRATGSELLFQIASALKESSSDVKSFARTFTRIYEDIINERPSSMASINA
CCCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRMIGEYFLENGVNGIRDYIDGIAARYEESIMRAAEVAAKRVVEGDALITNSNSLAIRRL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHH
FKTLSDSKVKVKVYVTESRPGLEGLLMAEYLEKLGFEVYLIVDSAARFFMKNIDKAVLGA
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
EAVAVNGAVVSKIGTSVIALDAHEARVRVFVVAPTLKFSIETIYGELIKLPEGDWRLLMD
HHHHCCCHHHHHHCCEEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEC
EDTRRTLPENYRAFAPLYDVTPAEYVDGIATEKGLFAPQAIPIVIREVYGGFPPLVKPLE
CCHHHCCCHHHHHHCCHHCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
KIAMEVRRYLE
HHHHHHHHHCC
>Mature Secondary Structure 
SELERHGFTRRATGSELLFQIASALKESSSDVKSFARTFTRIYEDIINERPSSMASINA
CCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRMIGEYFLENGVNGIRDYIDGIAARYEESIMRAAEVAAKRVVEGDALITNSNSLAIRRL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHH
FKTLSDSKVKVKVYVTESRPGLEGLLMAEYLEKLGFEVYLIVDSAARFFMKNIDKAVLGA
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
EAVAVNGAVVSKIGTSVIALDAHEARVRVFVVAPTLKFSIETIYGELIKLPEGDWRLLMD
HHHHCCCHHHHHHCCEEEEEECCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEC
EDTRRTLPENYRAFAPLYDVTPAEYVDGIATEKGLFAPQAIPIVIREVYGGFPPLVKPLE
CCHHHCCCHHHHHHCCHHCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
KIAMEVRRYLE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]