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The map label for this gene is aIF-2BII [H]

Identifier: 218883770

GI number: 218883770

Start: 427967

End: 428965

Strand: Reverse

Name: aIF-2BII [H]

Synonym: DKAM_0459

Alternate gene names: 218883770

Gene position: 428965-427967 (Counterclockwise)

Preceding gene: 218883771

Following gene: 218883769

Centisome position: 31.42

GC content: 47.55

Gene sequence:

>999_bases
ATGAGCGATGTTAGTATACCTCCAAAGGTCCTTGAGATAGCTGATGGAATAAAGACGATGAGGATCCGGGGAGCTGGTAA
GATCGGGCGGGCAGCAGCCGAAGCTTTGAAAATAGCGGCAGAGGAGTATAATGGGCCACGGGATGCATCCCTATTTAAGA
AGTATATTGGAAGAGTCGCCGATATACTCATATCGACGAGGCCTACCGCTGTAAGCCTACCTAACGCAGTCATGTTTATT
CTTTCCAGTCTAAGGGATCAATACGGCTTCGACGAGGCCCATTCAGCCATAGTGAGTGCTGCTAATAGATTCATCGAGGA
AAGCCTGAACGCGGTTAAGAAGATAAGTGAAATGGGTGCTAAGAGGATAAAGGAGAACTCCATCATACTTACACATTGCC
ACAGCAGCGTCGCAGTGAATACTATAACTGAAGCATATAGACAAGGCAAGGTGGTGAAGGTCTACAGTACCGAGACACGT
CCATTCTACCAGGGCAGGATAACCACAACGCAGCTCCTGAATAACGGGGTACCTGTTGTCCAGATACCTGATAGTGCTGT
GAGGTATGTTATGAATGATGTGGATTACGTGGTAATAGGGGCTGACACGATTACAAGTAATGGAGCAGTGATAAACAAGA
TTGGTACAAGCCAGGTAGCTTTGGCAGCCAAGGAGGCCAGGGTACGCGTCTACGTTGTAGCCGAGTCATATAAGTTCTCA
CCTATAACACTCGTCGGGGAACTCGTGCCAATAGAGTTCCGTGATCCAAGCGAGATAGTCCCCGAAGAGTGGTTGAAGCA
GCATCCAGGCGTCAAAGTATTGAACCCCTCATTCGATGTCACGCCTCCCGAGTACATTGACGCCATAGTAACTGAAGTCG
GAGTTATACCACCTCAATCAGCGATACTCGTGCTCATGGAGAGGCTTGGCTGGGCACTAGAAAAGATTAAACAGGGTTTA
TCAATATCTACAATAAGGTTTGAGGACTTGTTGGAGTAA

Upstream 100 bases:

>100_bases
CGCAGGCGATACCGATAGTCATCAGGGAGGTCTACGGAGGCTTTCCACCTCTTGTAAAGCCCCTTGAGAAAATAGCGATG
GAGGTAAGGAGGTACCTGGA

Downstream 100 bases:

>100_bases
GATGTGTATGTCCAATATATTAAAGATGAAGCAGGGGATAGTGAGACTAATAGATGAATCAAGCGAGCAAGCCTATAAGA
TAGCCTTCTATTCAAATCCT

Product: translation initiation factor IF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSDVSIPPKVLEIADGIKTMRIRGAGKIGRAAAEALKIAAEEYNGPRDASLFKKYIGRVADILISTRPTAVSLPNAVMFI
LSSLRDQYGFDEAHSAIVSAANRFIEESLNAVKKISEMGAKRIKENSIILTHCHSSVAVNTITEAYRQGKVVKVYSTETR
PFYQGRITTTQLLNNGVPVVQIPDSAVRYVMNDVDYVVIGADTITSNGAVINKIGTSQVALAAKEARVRVYVVAESYKFS
PITLVGELVPIEFRDPSEIVPEEWLKQHPGVKVLNPSFDVTPPEYIDAIVTEVGVIPPQSAILVLMERLGWALEKIKQGL
SISTIRFEDLLE

Sequences:

>Translated_332_residues
MSDVSIPPKVLEIADGIKTMRIRGAGKIGRAAAEALKIAAEEYNGPRDASLFKKYIGRVADILISTRPTAVSLPNAVMFI
LSSLRDQYGFDEAHSAIVSAANRFIEESLNAVKKISEMGAKRIKENSIILTHCHSSVAVNTITEAYRQGKVVKVYSTETR
PFYQGRITTTQLLNNGVPVVQIPDSAVRYVMNDVDYVVIGADTITSNGAVINKIGTSQVALAAKEARVRVYVVAESYKFS
PITLVGELVPIEFRDPSEIVPEEWLKQHPGVKVLNPSFDVTPPEYIDAIVTEVGVIPPQSAILVLMERLGWALEKIKQGL
SISTIRFEDLLE
>Mature_331_residues
SDVSIPPKVLEIADGIKTMRIRGAGKIGRAAAEALKIAAEEYNGPRDASLFKKYIGRVADILISTRPTAVSLPNAVMFIL
SSLRDQYGFDEAHSAIVSAANRFIEESLNAVKKISEMGAKRIKENSIILTHCHSSVAVNTITEAYRQGKVVKVYSTETRP
FYQGRITTTQLLNNGVPVVQIPDSAVRYVMNDVDYVVIGADTITSNGAVINKIGTSQVALAAKEARVRVYVVAESYKFSP
ITLVGELVPIEFRDPSEIVPEEWLKQHPGVKVLNPSFDVTPPEYIDAIVTEVGVIPPQSAILVLMERLGWALEKIKQGLS
ISTIRFEDLLE

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI78000158, Length=286, Percent_Identity=30.0699300699301, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI78000156, Length=286, Percent_Identity=30.0699300699301, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI187607323, Length=286, Percent_Identity=30.0699300699301, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI72534748, Length=310, Percent_Identity=28.0645161290323, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4503503, Length=193, Percent_Identity=34.1968911917098, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7657058, Length=293, Percent_Identity=26.962457337884, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI23943880, Length=147, Percent_Identity=38.7755102040816, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17557123, Length=221, Percent_Identity=33.4841628959276, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557462, Length=307, Percent_Identity=29.6416938110749, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322878, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325375, Length=375, Percent_Identity=27.4666666666667, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321520, Length=264, Percent_Identity=28.4090909090909, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323322, Length=213, Percent_Identity=28.6384976525822, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357667, Length=328, Percent_Identity=31.0975609756098, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24651647, Length=328, Percent_Identity=31.0975609756098, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358605, Length=225, Percent_Identity=32, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281364091, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24659399, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24659407, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI19922816, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18543295, Length=222, Percent_Identity=27.9279279279279, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 36366; Mature: 36235

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVSIPPKVLEIADGIKTMRIRGAGKIGRAAAEALKIAAEEYNGPRDASLFKKYIGRVA
CCCCCCCHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DILISTRPTAVSLPNAVMFILSSLRDQYGFDEAHSAIVSAANRFIEESLNAVKKISEMGA
HHHHCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRIKENSIILTHCHSSVAVNTITEAYRQGKVVKVYSTETRPFYQGRITTTQLLNNGVPVV
HHHCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCHHHHHHHCCCCEE
QIPDSAVRYVMNDVDYVVIGADTITSNGAVINKIGTSQVALAAKEARVRVYVVAESYKFS
ECCHHHHHHHHCCCCEEEEECCEECCCCEEEEECCCHHHHHEECCCEEEEEEEECCCCCC
PITLVGELVPIEFRDPSEIVPEEWLKQHPGVKVLNPSFDVTPPEYIDAIVTEVGVIPPQS
CEEEEEEEEEEEECCCHHCCCHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHH
AILVLMERLGWALEKIKQGLSISTIRFEDLLE
HHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCC
>Mature Secondary Structure 
SDVSIPPKVLEIADGIKTMRIRGAGKIGRAAAEALKIAAEEYNGPRDASLFKKYIGRVA
CCCCCCHHHHHHHCCHHEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DILISTRPTAVSLPNAVMFILSSLRDQYGFDEAHSAIVSAANRFIEESLNAVKKISEMGA
HHHHCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRIKENSIILTHCHSSVAVNTITEAYRQGKVVKVYSTETRPFYQGRITTTQLLNNGVPVV
HHHCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEECCCCHHHHHHHCCCCEE
QIPDSAVRYVMNDVDYVVIGADTITSNGAVINKIGTSQVALAAKEARVRVYVVAESYKFS
ECCHHHHHHHHCCCCEEEEECCEECCCCEEEEECCCHHHHHEECCCEEEEEEEECCCCCC
PITLVGELVPIEFRDPSEIVPEEWLKQHPGVKVLNPSFDVTPPEYIDAIVTEVGVIPPQS
CEEEEEEEEEEEECCCHHCCCHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHH
AILVLMERLGWALEKIKQGLSISTIRFEDLLE
HHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]