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The map label for this gene is glmU [H]

Identifier: 218883425

GI number: 218883425

Start: 96775

End: 97902

Strand: Reverse

Name: glmU [H]

Synonym: DKAM_0111

Alternate gene names: 218883425

Gene position: 97902-96775 (Counterclockwise)

Preceding gene: 218883428

Following gene: 218883424

Centisome position: 7.17

GC content: 42.64

Gene sequence:

>1128_bases
GTGAAAGCAGTGGTGCTTGCTGGAGGACTTGGGACAAGACTTTACCCCTTAACCAAGATCACTCCTAAACCCATGATACC
TCTAGCAGGCAAGCCTATATTAGAATACATTACAGAATGGCTACATAAACACGGCGTTAAAGATATAATCATTGTGGCCC
GCTACCTTGGCGACCAGATATTGGCATACTTTAAGGATCACTCATATGTTAGAGCCATGCTGCTTGATTCAAAGGATACA
GCTGACGCTATAAGATTACTCGACGGCATCCTTGAAGAATCCTTTATAGTTACAATGGGTGATACATTATGTAATATTGT
TTATAGAGAGATCTATGAATCACATGAGTCTTCAAACGCTGTTGCAACCATAGCGCTTAAACAGGTTGAAAACCCACTAC
CATACGGCATAGTCTATTTGAACGAGCAGGGGGATATACAGTTATTCATTGAGAAACCTCTATCCATAGAGGTATACTTG
CTGAATATAGCATATTACAGGAGGAAGAGTTTATCGGCCTACGAGAACCTCATCAACACCGGGATATACGTGCTCAGCCA
ACACATACTTGAGATCCTCGAGAAGAACCCTGGTCTACTGGATTTTGGGAGGCATGTCTTCCCCTATTTGATTGAAAATG
GATACAAGGTTAAAGGCTATATTTTGAAGCATAATGTGTACTGGAACGATGTTGGTAGACTGGAAACATATAGGAACGTG
GCATGGGATCTCCTCGATGGTGAAATAGCTGGTTTTGAACCGGGAGCACCAAAGATCTCGCCCGGCATCTATATGCATGA
ATCCTCCCTGGTGAAGGGTGAGGTACATCCTCCAGTCTATATAGGTAGGAATGTCGTTATAGAGGATGATACGGTCATCG
GACCCTACGTCATACTAGAGGATAACGTGAAAGTGGAACATGGATCTATTATACGGGAAAGCATCATATGGCATAACACT
ATAATTAGAAGGGGGTCGAAAATATATGATACAATAATAATGAACAATGTAGAGGTAGCCGAAAACACGAGAATGATGGC
CTCAGTGATCGGCACGGGCAACCATGTAAGAGGGGATATTTCTAAGAAAAACATAGAGCCAGTAGAGGTGACGCCGCCTT
ATGCTTAA

Upstream 100 bases:

>100_bases
CTAGAAAAGGAGGTCTGATAATGTTTTACCGGTTTCAGAAGATATGCGGTAGGTTCGGGGAGATGTCCCTGTTTGCTTCA
GTCCTTTCTAGGTGGTATGA

Downstream 100 bases:

>100_bases
ATACGTTGATGGAAGAATAACAGGAGAACCACTAGTCGATATCAAGCTAGATGATGTTGTCATGCTTGGAGCGGTATTTG
GCTCGTTACTCGGTAAGAGA

Product: Nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKAVVLAGGLGTRLYPLTKITPKPMIPLAGKPILEYITEWLHKHGVKDIIIVARYLGDQILAYFKDHSYVRAMLLDSKDT
ADAIRLLDGILEESFIVTMGDTLCNIVYREIYESHESSNAVATIALKQVENPLPYGIVYLNEQGDIQLFIEKPLSIEVYL
LNIAYYRRKSLSAYENLINTGIYVLSQHILEILEKNPGLLDFGRHVFPYLIENGYKVKGYILKHNVYWNDVGRLETYRNV
AWDLLDGEIAGFEPGAPKISPGIYMHESSLVKGEVHPPVYIGRNVVIEDDTVIGPYVILEDNVKVEHGSIIRESIIWHNT
IIRRGSKIYDTIIMNNVEVAENTRMMASVIGTGNHVRGDISKKNIEPVEVTPPYA

Sequences:

>Translated_375_residues
MKAVVLAGGLGTRLYPLTKITPKPMIPLAGKPILEYITEWLHKHGVKDIIIVARYLGDQILAYFKDHSYVRAMLLDSKDT
ADAIRLLDGILEESFIVTMGDTLCNIVYREIYESHESSNAVATIALKQVENPLPYGIVYLNEQGDIQLFIEKPLSIEVYL
LNIAYYRRKSLSAYENLINTGIYVLSQHILEILEKNPGLLDFGRHVFPYLIENGYKVKGYILKHNVYWNDVGRLETYRNV
AWDLLDGEIAGFEPGAPKISPGIYMHESSLVKGEVHPPVYIGRNVVIEDDTVIGPYVILEDNVKVEHGSIIRESIIWHNT
IIRRGSKIYDTIIMNNVEVAENTRMMASVIGTGNHVRGDISKKNIEPVEVTPPYA
>Mature_375_residues
MKAVVLAGGLGTRLYPLTKITPKPMIPLAGKPILEYITEWLHKHGVKDIIIVARYLGDQILAYFKDHSYVRAMLLDSKDT
ADAIRLLDGILEESFIVTMGDTLCNIVYREIYESHESSNAVATIALKQVENPLPYGIVYLNEQGDIQLFIEKPLSIEVYL
LNIAYYRRKSLSAYENLINTGIYVLSQHILEILEKNPGLLDFGRHVFPYLIENGYKVKGYILKHNVYWNDVGRLETYRNV
AWDLLDGEIAGFEPGAPKISPGIYMHESSLVKGEVHPPVYIGRNVVIEDDTVIGPYVILEDNVKVEHGSIIRESIIWHNT
IIRRGSKIYDTIIMNNVEVAENTRMMASVIGTGNHVRGDISKKNIEPVEVTPPYA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=354, Percent_Identity=26.8361581920904, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI11761619, Length=326, Percent_Identity=27.3006134969325, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI9966779, Length=421, Percent_Identity=21.3776722090261, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI83267879, Length=410, Percent_Identity=17.5609756097561, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI262205273, Length=412, Percent_Identity=21.1165048543689, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=355, Percent_Identity=27.887323943662, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320148, Length=372, Percent_Identity=24.4623655913978, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320417, Length=400, Percent_Identity=23.5, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355443, Length=334, Percent_Identity=28.1437125748503, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644084, Length=334, Percent_Identity=28.1437125748503, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 42365; Mature: 42365

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLAGGLGTRLYPLTKITPKPMIPLAGKPILEYITEWLHKHGVKDIIIVARYLGDQI
CCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LAYFKDHSYVRAMLLDSKDTADAIRLLDGILEESFIVTMGDTLCNIVYREIYESHESSNA
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCC
VATIALKQVENPLPYGIVYLNEQGDIQLFIEKPLSIEVYLLNIAYYRRKSLSAYENLINT
EEEEEEEHHCCCCCEEEEEECCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHHH
GIYVLSQHILEILEKNPGLLDFGRHVFPYLIENGYKVKGYILKHNVYWNDVGRLETYRNV
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCEEEEEEEEEECCEECCCHHHHHHHHH
AWDLLDGEIAGFEPGAPKISPGIYMHESSLVKGEVHPPVYIGRNVVIEDDTVIGPYVILE
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCEECCCCCCEEECCEEEEECCCEECCEEEEE
DNVKVEHGSIIRESIIWHNTIIRRGSKIYDTIIMNNVEVAENTRMMASVIGTGNHVRGDI
CCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCC
SKKNIEPVEVTPPYA
CCCCCCCEECCCCCC
>Mature Secondary Structure
MKAVVLAGGLGTRLYPLTKITPKPMIPLAGKPILEYITEWLHKHGVKDIIIVARYLGDQI
CCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LAYFKDHSYVRAMLLDSKDTADAIRLLDGILEESFIVTMGDTLCNIVYREIYESHESSNA
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCCC
VATIALKQVENPLPYGIVYLNEQGDIQLFIEKPLSIEVYLLNIAYYRRKSLSAYENLINT
EEEEEEEHHCCCCCEEEEEECCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHHHH
GIYVLSQHILEILEKNPGLLDFGRHVFPYLIENGYKVKGYILKHNVYWNDVGRLETYRNV
HHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCEEEEEEEEEECCEECCCHHHHHHHHH
AWDLLDGEIAGFEPGAPKISPGIYMHESSLVKGEVHPPVYIGRNVVIEDDTVIGPYVILE
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCEECCCCCCEEECCEEEEECCCEECCEEEEE
DNVKVEHGSIIRESIIWHNTIIRRGSKIYDTIIMNNVEVAENTRMMASVIGTGNHVRGDI
CCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCC
SKKNIEPVEVTPPYA
CCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]