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The map label for this gene is hemC [H]

Identifier: 218533190

GI number: 218533190

Start: 5694793

End: 5695722

Strand: Reverse

Name: hemC [H]

Synonym: Mchl_5316

Alternate gene names: 218533190

Gene position: 5695722-5694793 (Counterclockwise)

Preceding gene: 218533191

Following gene: 218533188

Centisome position: 98.58

GC content: 69.46

Gene sequence:

>930_bases
ATGAGCCTTTCGCGCGCCTTGAGAATTGGAACCCGCGGCAGCCCGATGGCGCTGGCCCAGACCGGCATGGTCCGCGATCG
GATTGTCGCGGCCAATCCGGGATTGGAGACGGAGATCGTCGTCGTCTCGACCGTGGCCGACCGCGTGCTCGATCGGCCGC
TCTCCGAGATCGGCGGCAAGGGCCTGTTCACCAAGGAACTCGAACAGGCGCTGTTTGCCGACGAGATCGATGTCGCCGTC
CACTCGATGAAGGACGTGGAGACTTGGCTGCCCGACGGGCTCGCTATCGCCTGCATCCTGGAACGCGACGACCCGCGCGA
CGCCTTCCTCAGCGCGAACGGAGCCAACGGCTTGGCCGATTTGCCGCCCGGTGCACGGGTCGGCACCTCTTCGCTCAGGC
GTGGGGCGCAGGTGCTGATGCACCGGCCCGATCTCACCATCGTGCCCCTGCGCGGCAATGCCAACACCCGGATGCGCAAG
CTGGAGGCGGGGGAGTGCGACGCCACGCTGCTAGCGCTCGCCGGCCTTCAGCGCCTCGGGATGGAGGATGTCGCCCGCAG
TGTGCTGTCGGTAGAAGAAATGCTCCCGGCCGTGGCGCAGGGCGCACTCGGCATCGAGTGCCGGGCCGGCGACGACGCGA
TCCGGGCGCTGCTGGCGCCGGTTGCCTGCGCCACCACGACGACGGCGCTCGACGCAGAACGCGGGCTGCTTGCCGAACTC
GACGGTTCGTGCCGCACCCCCATCGCGGCGCTCGCGCAGGTGAAGGGGGACCGCATCAGCCTCGACGGGTTGCTGTTCCT
GCCGGATGGCAGCCGCCACTGGGAGGTCCATCGCGAGGGACTGGCCGCGGATGCCGACGCGATCGGCCGCGATGCCGGGG
CCGAGCTGAAGCGGGCGGCGGGCGACGTCTACTTCGCCCACCTCAAGTAG

Upstream 100 bases:

>100_bases
AAAGTTTTCCGACAAAGTGCCGCCGGGATCGCTCGTCCCGCGCAGCCTCACAGGCGCGCCAGCGCGTGACGGGCGGCATC
GTCTCGGGTAAAGCGCGGGG

Downstream 100 bases:

>100_bases
CCCCTCTCATCCCAAATCCGCTTGATCCCCTTGGGATCGCGGATCTGGGCCTGGGCGGGATCCCGTCGTGTCGGCACGAT
GGGTTGCCTCCTCGCGCGTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSLSRALRIGTRGSPMALAQTGMVRDRIVAANPGLETEIVVVSTVADRVLDRPLSEIGGKGLFTKELEQALFADEIDVAV
HSMKDVETWLPDGLAIACILERDDPRDAFLSANGANGLADLPPGARVGTSSLRRGAQVLMHRPDLTIVPLRGNANTRMRK
LEAGECDATLLALAGLQRLGMEDVARSVLSVEEMLPAVAQGALGIECRAGDDAIRALLAPVACATTTTALDAERGLLAEL
DGSCRTPIAALAQVKGDRISLDGLLFLPDGSRHWEVHREGLAADADAIGRDAGAELKRAAGDVYFAHLK

Sequences:

>Translated_309_residues
MSLSRALRIGTRGSPMALAQTGMVRDRIVAANPGLETEIVVVSTVADRVLDRPLSEIGGKGLFTKELEQALFADEIDVAV
HSMKDVETWLPDGLAIACILERDDPRDAFLSANGANGLADLPPGARVGTSSLRRGAQVLMHRPDLTIVPLRGNANTRMRK
LEAGECDATLLALAGLQRLGMEDVARSVLSVEEMLPAVAQGALGIECRAGDDAIRALLAPVACATTTTALDAERGLLAEL
DGSCRTPIAALAQVKGDRISLDGLLFLPDGSRHWEVHREGLAADADAIGRDAGAELKRAAGDVYFAHLK
>Mature_308_residues
SLSRALRIGTRGSPMALAQTGMVRDRIVAANPGLETEIVVVSTVADRVLDRPLSEIGGKGLFTKELEQALFADEIDVAVH
SMKDVETWLPDGLAIACILERDDPRDAFLSANGANGLADLPPGARVGTSSLRRGAQVLMHRPDLTIVPLRGNANTRMRKL
EAGECDATLLALAGLQRLGMEDVARSVLSVEEMLPAVAQGALGIECRAGDDAIRALLAPVACATTTTALDAERGLLAELD
GSCRTPIAALAQVKGDRISLDGLLFLPDGSRHWEVHREGLAADADAIGRDAGAELKRAAGDVYFAHLK

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=270, Percent_Identity=44.4444444444444, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI20149500, Length=270, Percent_Identity=44.4444444444444, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=48.6394557823129, Blast_Score=252, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319996, Length=255, Percent_Identity=38.0392156862745, Blast_Score=162, Evalue=7e-41,
Organism=Drosophila melanogaster, GI20130425, Length=260, Percent_Identity=43.4615384615385, Blast_Score=198, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32624; Mature: 32493

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSRALRIGTRGSPMALAQTGMVRDRIVAANPGLETEIVVVSTVADRVLDRPLSEIGGK
CCHHHHEECCCCCCCHHHHHHCCHHHEEEECCCCCCEEEEEEHHHHHHHHHCCHHHHCCC
GLFTKELEQALFADEIDVAVHSMKDVETWLPDGLAIACILERDDPRDAFLSANGANGLAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHEEECCCCCCCCC
LPPGARVGTSSLRRGAQVLMHRPDLTIVPLRGNANTRMRKLEAGECDATLLALAGLQRLG
CCCCCCCCHHHHHHHHHHHEECCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHCC
MEDVARSVLSVEEMLPAVAQGALGIECRAGDDAIRALLAPVACATTTTALDAERGLLAEL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
DGSCRTPIAALAQVKGDRISLDGLLFLPDGSRHWEVHREGLAADADAIGRDAGAELKRAA
CCCCCCHHHHHHHHCCCEEEECEEEEECCCCCCHHHHHCCCCCCHHHHCCCCCHHHHHHC
GDVYFAHLK
CCEEEEEEC
>Mature Secondary Structure 
SLSRALRIGTRGSPMALAQTGMVRDRIVAANPGLETEIVVVSTVADRVLDRPLSEIGGK
CHHHHEECCCCCCCHHHHHHCCHHHEEEECCCCCCEEEEEEHHHHHHHHHCCHHHHCCC
GLFTKELEQALFADEIDVAVHSMKDVETWLPDGLAIACILERDDPRDAFLSANGANGLAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHEEECCCCCCCCC
LPPGARVGTSSLRRGAQVLMHRPDLTIVPLRGNANTRMRKLEAGECDATLLALAGLQRLG
CCCCCCCCHHHHHHHHHHHEECCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHCC
MEDVARSVLSVEEMLPAVAQGALGIECRAGDDAIRALLAPVACATTTTALDAERGLLAEL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
DGSCRTPIAALAQVKGDRISLDGLLFLPDGSRHWEVHREGLAADADAIGRDAGAELKRAA
CCCCCCHHHHHHHHCCCEEEECEEEEECCCCCCHHHHHCCCCCCHHHHCCCCCHHHHHHC
GDVYFAHLK
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA