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The map label for this gene is degP [H]

Identifier: 218533033

GI number: 218533033

Start: 5524726

End: 5526237

Strand: Reverse

Name: degP [H]

Synonym: Mchl_5157

Alternate gene names: 218533033

Gene position: 5526237-5524726 (Counterclockwise)

Preceding gene: 218533034

Following gene: 218533032

Centisome position: 95.64

GC content: 70.17

Gene sequence:

>1512_bases
ATGACCATGACTGTCCGCCGCCGCGCCTTCGCCTCCGTCGCCGCAGCCGCCCTCGTCGCGGGCGGCGCCGCCGGGTTCGG
CCTGACCGAGCCCATGACCCCGGCTTACGCCCAGGCCCTGCCCAAGACCCCGATCGAAGCGCCCGAGCACCCGCCGGGCT
CGTTTGCCAACGTCGTCGACAAGGTGAAGCCGGGCGTCGTCGCCGTGAAGGTGAAGCTCGACAACAGCGCCGACGATGAC
GACGACAGCGCGGGCGGTCCCAACCTGCAGCAGGTGCCGCCGCAGCTGCGCGAGTTCTTCAAGCGCTTCGGCCAGGGCGG
TCCGGGTGGTCAGGGCGGGCGCGGCATGCCGCAGCGCGGCGAGCGCGGCGCGGTCGGCTCGGGCTTCATCATCTCGGCGG
ACGGCTACGTCGTCACCAACAACCACGTCGTCGACAAGGCCAAGACCGTGCAGGTCACGCTCGACGACAACCGCACCCTC
GATGCCAAGGTGATCGGCAAGGATCCGAAGACCGACATCGCGCTGCTCAAGATCACCGAGAGCGGCAGTTACCCCTATGT
CCAGTTCGGCAAGAGCGCCCCGCGCGTCGGCGATTGGGTCGTCGCCATCGGCAACCCGTTCGGCCTCGGCGGTACGGTGA
CGGCGGGCATCGTCTCGGCCCGCGGCCGTGACATCGGCGCCGGCCCCTACGACGACTTCCTGCAGATCGACGCGCCGATC
AACAAGGGCAATTCCGGCGGCCCGACCTTCAACGTCAACGGTGAGGTCGTGGGCGTGAACACGGCGATCGCCTCACCGTC
CGGCGGCTCGGTCGGCCTCGCCTTTGCGATCCCCGCCGAGACGGTGCAGACGGTGGTCGATCAGCTCCGCACCGACGGCA
AGGTGGTGCGCGGTTATCTCGGCGTGCAGGTCCAGCCGGTGACCAAGGACATCGCCGACGGGCTCGGCCTCGACAAGGCC
AAGGGCGCGCTGGTCGATCACGCCGAGAACGGTACGCCCGCGGCCAAGGCCGGCCTGAAGTCGGGTGACGTGATCGAGTC
GGTCAACGGCGCCCCGGTCAACGATGCCCGCGACCTCTCGCGCCGCATCGCCGGCCTCAAGCCTGGCACCGAGGTGAAGC
TCGCCTATCTGCGGGGCGGCAAGAGCGACGTCGCGACGGTCGAACTCGGCACGCAGCCGACCGACGCCAAGGTCGCGAGC
CGCAGTGACAGCACGTCCGGTGGCCAGGCGCGCCTCGGCCTCAGCCTGGCCCCTGCCAGCGAGATCGGCCTCGGCGACGA
GGGCGTGGCGGTGATGGATGTCGATCCCGACGGTCCGGCCGCGGCCAAGGGCATCGCCCAGGGCGACGTGATCCTGGATG
TCGCTGGCACCAGCGTCTCGAAGCCCTCCGAGGTGCAGGCGCAGATCCGCGCCGCAGAATCGAACGGCCGCAAGGCGGTG
CTGATGCGGGTGAAGAGCGCCAAGGGCCAGACCCGCTTCGTCGCCGTGGCCCTCGGCAAGAAGGAGGGCTGA

Upstream 100 bases:

>100_bases
CGGCGGTCAGGCTCGGGCCTCTACGAGTCTCCTCACGGATCGCCGCCCCGACGTTCAACGGAAGGGCAGCCGACCGGCCC
ATTTCCCGTCGGAGACCTCC

Downstream 100 bases:

>100_bases
TCCCCTCGCAGATCACGGCCGGGCCGCCTCCGGCCCCGCCGACCGCCCTGCATCTCCTCCCGACTTCGCGCCCGCTCCTA
GAGCGGGCGTTTTTTCGTTC

Product: protease Do

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTMTVRRRAFASVAAAALVAGGAAGFGLTEPMTPAYAQALPKTPIEAPEHPPGSFANVVDKVKPGVVAVKVKLDNSADDD
DDSAGGPNLQQVPPQLREFFKRFGQGGPGGQGGRGMPQRGERGAVGSGFIISADGYVVTNNHVVDKAKTVQVTLDDNRTL
DAKVIGKDPKTDIALLKITESGSYPYVQFGKSAPRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQIDAPI
NKGNSGGPTFNVNGEVVGVNTAIASPSGGSVGLAFAIPAETVQTVVDQLRTDGKVVRGYLGVQVQPVTKDIADGLGLDKA
KGALVDHAENGTPAAKAGLKSGDVIESVNGAPVNDARDLSRRIAGLKPGTEVKLAYLRGGKSDVATVELGTQPTDAKVAS
RSDSTSGGQARLGLSLAPASEIGLGDEGVAVMDVDPDGPAAAKGIAQGDVILDVAGTSVSKPSEVQAQIRAAESNGRKAV
LMRVKSAKGQTRFVAVALGKKEG

Sequences:

>Translated_503_residues
MTMTVRRRAFASVAAAALVAGGAAGFGLTEPMTPAYAQALPKTPIEAPEHPPGSFANVVDKVKPGVVAVKVKLDNSADDD
DDSAGGPNLQQVPPQLREFFKRFGQGGPGGQGGRGMPQRGERGAVGSGFIISADGYVVTNNHVVDKAKTVQVTLDDNRTL
DAKVIGKDPKTDIALLKITESGSYPYVQFGKSAPRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQIDAPI
NKGNSGGPTFNVNGEVVGVNTAIASPSGGSVGLAFAIPAETVQTVVDQLRTDGKVVRGYLGVQVQPVTKDIADGLGLDKA
KGALVDHAENGTPAAKAGLKSGDVIESVNGAPVNDARDLSRRIAGLKPGTEVKLAYLRGGKSDVATVELGTQPTDAKVAS
RSDSTSGGQARLGLSLAPASEIGLGDEGVAVMDVDPDGPAAAKGIAQGDVILDVAGTSVSKPSEVQAQIRAAESNGRKAV
LMRVKSAKGQTRFVAVALGKKEG
>Mature_502_residues
TMTVRRRAFASVAAAALVAGGAAGFGLTEPMTPAYAQALPKTPIEAPEHPPGSFANVVDKVKPGVVAVKVKLDNSADDDD
DSAGGPNLQQVPPQLREFFKRFGQGGPGGQGGRGMPQRGERGAVGSGFIISADGYVVTNNHVVDKAKTVQVTLDDNRTLD
AKVIGKDPKTDIALLKITESGSYPYVQFGKSAPRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQIDAPIN
KGNSGGPTFNVNGEVVGVNTAIASPSGGSVGLAFAIPAETVQTVVDQLRTDGKVVRGYLGVQVQPVTKDIADGLGLDKAK
GALVDHAENGTPAAKAGLKSGDVIESVNGAPVNDARDLSRRIAGLKPGTEVKLAYLRGGKSDVATVELGTQPTDAKVASR
SDSTSGGQARLGLSLAPASEIGLGDEGVAVMDVDPDGPAAAKGIAQGDVILDVAGTSVSKPSEVQAQIRAAESNGRKAVL
MRVKSAKGQTRFVAVALGKKEG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=280, Percent_Identity=38.9285714285714, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI24308541, Length=278, Percent_Identity=35.2517985611511, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI22129776, Length=280, Percent_Identity=33.9285714285714, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI7019477, Length=251, Percent_Identity=37.4501992031873, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=38.1374722838137, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789629, Length=460, Percent_Identity=38.2608695652174, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=37.9928315412186, Blast_Score=182, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=34.0350877192982, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51181; Mature: 51050

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTVRRRAFASVAAAALVAGGAAGFGLTEPMTPAYAQALPKTPIEAPEHPPGSFANVVD
CCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHH
KVKPGVVAVKVKLDNSADDDDDSAGGPNLQQVPPQLREFFKRFGQGGPGGQGGRGMPQRG
HCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
ERGAVGSGFIISADGYVVTNNHVVDKAKTVQVTLDDNRTLDAKVIGKDPKTDIALLKITE
CCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEEEC
SGSYPYVQFGKSAPRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQIDAPI
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCC
NKGNSGGPTFNVNGEVVGVNTAIASPSGGSVGLAFAIPAETVQTVVDQLRTDGKVVRGYL
CCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEE
GVQVQPVTKDIADGLGLDKAKGALVDHAENGTPAAKAGLKSGDVIESVNGAPVNDARDLS
CEEEEEHHHHHHHCCCCCCCCCCEEECCCCCCCHHHCCCCCCCHHHCCCCCCCCHHHHHH
RRIAGLKPGTEVKLAYLRGGKSDVATVELGTQPTDAKVASRSDSTSGGQARLGLSLAPAS
HHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHCCCCCCCCCCEEEEEEECCHH
EIGLGDEGVAVMDVDPDGPAAAKGIAQGDVILDVAGTSVSKPSEVQAQIRAAESNGRKAV
HCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHEEECCCCCCEEE
LMRVKSAKGQTRFVAVALGKKEG
EEEEECCCCCEEEEEEEECCCCC
>Mature Secondary Structure 
TMTVRRRAFASVAAAALVAGGAAGFGLTEPMTPAYAQALPKTPIEAPEHPPGSFANVVD
CEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHH
KVKPGVVAVKVKLDNSADDDDDSAGGPNLQQVPPQLREFFKRFGQGGPGGQGGRGMPQRG
HCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
ERGAVGSGFIISADGYVVTNNHVVDKAKTVQVTLDDNRTLDAKVIGKDPKTDIALLKITE
CCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEEEC
SGSYPYVQFGKSAPRVGDWVVAIGNPFGLGGTVTAGIVSARGRDIGAGPYDDFLQIDAPI
CCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCC
NKGNSGGPTFNVNGEVVGVNTAIASPSGGSVGLAFAIPAETVQTVVDQLRTDGKVVRGYL
CCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEE
GVQVQPVTKDIADGLGLDKAKGALVDHAENGTPAAKAGLKSGDVIESVNGAPVNDARDLS
CEEEEEHHHHHHHCCCCCCCCCCEEECCCCCCCHHHCCCCCCCHHHCCCCCCCCHHHHHH
RRIAGLKPGTEVKLAYLRGGKSDVATVELGTQPTDAKVASRSDSTSGGQARLGLSLAPAS
HHHHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHCCCCCCCCCCEEEEEEECCHH
EIGLGDEGVAVMDVDPDGPAAAKGIAQGDVILDVAGTSVSKPSEVQAQIRAAESNGRKAV
HCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHEEECCCCCCEEE
LMRVKSAKGQTRFVAVALGKKEG
EEEEECCCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]