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The map label for this gene is cyoB [H]

Identifier: 218532591

GI number: 218532591

Start: 4984962

End: 4986965

Strand: Reverse

Name: cyoB [H]

Synonym: Mchl_4705

Alternate gene names: 218532591

Gene position: 4986965-4984962 (Counterclockwise)

Preceding gene: 218532592

Following gene: 218532590

Centisome position: 86.31

GC content: 63.97

Gene sequence:

>2004_bases
ATGTTCGCAAACACGGACCTGCAGCACCTGCTGTTCGGGCGCCTCTCCCTGGAGGACATCCCGTTCCACGAACCGATCCT
GCAAGTGACCTTCGCAGGCGTCGCCGTGGCCGGGATCGCGGTGATCGCCGCCATCACCTATTTCCGCTTCTGGGGTCCGC
TCTGGCGCGACTGGTTGACCTCGGTCGACCACAAGAAGATCGGCATCATGTACGTCGTCCTGGCGCTCGTGATGCTGCTG
CGCGGCTTTGCCGACGCGTTGCTGATGCGCTCGCAGCAGGCGATCGCGTTCGGCTCCAACGAGGGCTTCCTGCCGCCGCA
CCACTACGACCAGATCTTCACCGCCCACGGCGTGATCATGATCTTCTTCGTGGCGATGCCGTTCGTCACCGGCCTGATGA
ACTACGTCGTGCCGCTGCAGATCGGCGCACGCGACGTCGCCTTCCCGTTCCTGAACAACTTCTCGTTCTGGATGACGGTG
TCCGGCGCGACCACGATCATGATCTCGCTGTTCGTCGGTGAGTTCGCCCGCACCGGCTGGCTCGCCTACCCGCCGCTCTC
GGGCGCGGACATGAGTCCGGGGGTCGGCGTCGACTACTACATCTGGGGCCTGCAGATCGCGGGCATCGGCACGACGCTGT
CCGGCATCAACCTCGTCGCGACCATCGTGAAGATGCGCGCGCCCGGCATGTCGATGATGAAGCTGCCGATCTTCACCTGG
ACCTCGCTGTGCACGAACGTGCTCATCGTGGCCGCCTTCCCGATCCTCGCCGCCGTTCTCGCGCTGCTGAGCCTCGACCG
CTACGTCGGCACGCACTTCTTCACGAACGACCTCGGCGGCAACCCGATGATGTACTTCAACCTCATCTGGATCTGGGGCC
ACCCGGAGGTCTACATCCTCATCCTGCCGGCCTTCGGCGTGTTCTCGGAGGTCACCTCGGCCTTCAGCGGCAAGCGCCTG
TTCGGCTACACCTCGATGGTCTACGCGACCGTCGTCATCACGATCCTGTCCTACCTCGTGTGGCTGCACCACTTCTTCAC
GATGGGTTCGGGCGCGAGCGTGAACTCGTTCTTCGGCCTCACGACGATGATCATCTCGATCCCGACGGGCGCGAAGATCT
TCAACTGGCTGTTCACGATGTACCGCGGCCGCATCCGCTTCGATGTGCCGATGCTGTGGACCGTCAGCTTCATGGTCACC
TTCACCATCGGTGGCATGACCGGCGTGCTGCTCGCCGTGCCCCCGGCCGACTTCGTGCTGCACAACTCGCTGTTCCTGAT
CGCGCACTTCCACAACGTGATCATCGGCGGCGTGCTGTTCGGCATGTTCGCCGGCGTGAACTACTGGTTCCCGAAGGCCT
TCGGCTTCCGGCTCGATGAGTTCTGGGGCAAGGTCAGCTTCTGGTTCTGGACCATCGGCTTCTACGTCGCCTTCATGCCG
CTCTATGTGCTGGGGCTCATGGGCGTGACCCGCCGCGCCCAGCACTTCGACGACCCGTCGCTGCAGATCTGGTTCGTGAT
CGCCGCCATCGGCGCGGGTCTGATCGCGCTGGGCATCGGTGCGATGATCGTCCAGTTCGCGGTCTCGATCAAAAACCGCG
AGGCGCTGCGCGACGTGACCGGCGATCCGTGGGAAGGCCGGACCCTCGAATGGGCGACCTCCTCGCCGCCGCCGGACTAC
AACTTCGCCTTCACGCCCGTGGTGCACAGCCTCGACGCGTGGTGGGACATGAAGGCCCGCGGCTTCCAGCGTCCGCTCTC
GGGCTACAAGCCGATCCACATGCCCAAGAACACCGCCACTGGCGTGATCCTGGGCGTGGTCAGCATCGTCTTCTCGTTCG
CGATGATCTGGTACATCTGGTGGCTCGCAGCGCTCACCTTCGTGGCGATGCTGGCAATCACGATCGCCCATACCTTCAAC
TACAACCGCGACTTCTACATCCCCGCTGAGACGGTCCGCCGGACCGAGCAGCAGCGGACCGAAGCGCTCGCGGCGCGGGT
CTGA

Upstream 100 bases:

>100_bases
CGATAAGACCCACGAGGGGAGCGGCCAAGGCCACTCCGCTCCCGACCAGACCAACAACTGATCCGTCGCCGCCTCAGGAT
TTACGGACGAGTTTCAACCC

Downstream 100 bases:

>100_bases
GCAGCATCATGGCAACGCACGCGACCCACACCCTCGTCGGCGACCGGATGTCCGGCGCCGACGTGCCGGACTTCCTCGAT
CTCGAGGGCGAGCATCACCC

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MFANTDLQHLLFGRLSLEDIPFHEPILQVTFAGVAVAGIAVIAAITYFRFWGPLWRDWLTSVDHKKIGIMYVVLALVMLL
RGFADALLMRSQQAIAFGSNEGFLPPHHYDQIFTAHGVIMIFFVAMPFVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTV
SGATTIMISLFVGEFARTGWLAYPPLSGADMSPGVGVDYYIWGLQIAGIGTTLSGINLVATIVKMRAPGMSMMKLPIFTW
TSLCTNVLIVAAFPILAAVLALLSLDRYVGTHFFTNDLGGNPMMYFNLIWIWGHPEVYILILPAFGVFSEVTSAFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGLTTMIISIPTGAKIFNWLFTMYRGRIRFDVPMLWTVSFMVT
FTIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGMFAGVNYWFPKAFGFRLDEFWGKVSFWFWTIGFYVAFMP
LYVLGLMGVTRRAQHFDDPSLQIWFVIAAIGAGLIALGIGAMIVQFAVSIKNREALRDVTGDPWEGRTLEWATSSPPPDY
NFAFTPVVHSLDAWWDMKARGFQRPLSGYKPIHMPKNTATGVILGVVSIVFSFAMIWYIWWLAALTFVAMLAITIAHTFN
YNRDFYIPAETVRRTEQQRTEALAARV

Sequences:

>Translated_667_residues
MFANTDLQHLLFGRLSLEDIPFHEPILQVTFAGVAVAGIAVIAAITYFRFWGPLWRDWLTSVDHKKIGIMYVVLALVMLL
RGFADALLMRSQQAIAFGSNEGFLPPHHYDQIFTAHGVIMIFFVAMPFVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTV
SGATTIMISLFVGEFARTGWLAYPPLSGADMSPGVGVDYYIWGLQIAGIGTTLSGINLVATIVKMRAPGMSMMKLPIFTW
TSLCTNVLIVAAFPILAAVLALLSLDRYVGTHFFTNDLGGNPMMYFNLIWIWGHPEVYILILPAFGVFSEVTSAFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGLTTMIISIPTGAKIFNWLFTMYRGRIRFDVPMLWTVSFMVT
FTIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGMFAGVNYWFPKAFGFRLDEFWGKVSFWFWTIGFYVAFMP
LYVLGLMGVTRRAQHFDDPSLQIWFVIAAIGAGLIALGIGAMIVQFAVSIKNREALRDVTGDPWEGRTLEWATSSPPPDY
NFAFTPVVHSLDAWWDMKARGFQRPLSGYKPIHMPKNTATGVILGVVSIVFSFAMIWYIWWLAALTFVAMLAITIAHTFN
YNRDFYIPAETVRRTEQQRTEALAARV
>Mature_667_residues
MFANTDLQHLLFGRLSLEDIPFHEPILQVTFAGVAVAGIAVIAAITYFRFWGPLWRDWLTSVDHKKIGIMYVVLALVMLL
RGFADALLMRSQQAIAFGSNEGFLPPHHYDQIFTAHGVIMIFFVAMPFVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTV
SGATTIMISLFVGEFARTGWLAYPPLSGADMSPGVGVDYYIWGLQIAGIGTTLSGINLVATIVKMRAPGMSMMKLPIFTW
TSLCTNVLIVAAFPILAAVLALLSLDRYVGTHFFTNDLGGNPMMYFNLIWIWGHPEVYILILPAFGVFSEVTSAFSGKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGLTTMIISIPTGAKIFNWLFTMYRGRIRFDVPMLWTVSFMVT
FTIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGMFAGVNYWFPKAFGFRLDEFWGKVSFWFWTIGFYVAFMP
LYVLGLMGVTRRAQHFDDPSLQIWFVIAAIGAGLIALGIGAMIVQFAVSIKNREALRDVTGDPWEGRTLEWATSSPPPDY
NFAFTPVVHSLDAWWDMKARGFQRPLSGYKPIHMPKNTATGVILGVVSIVFSFAMIWYIWWLAALTFVAMLAITIAHTFN
YNRDFYIPAETVRRTEQQRTEALAARV

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=508, Percent_Identity=38.3858267716535, Blast_Score=333, Evalue=4e-91,
Organism=Escherichia coli, GI1786634, Length=655, Percent_Identity=67.0229007633588, Blast_Score=926, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=535, Percent_Identity=37.5700934579439, Blast_Score=343, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.1538461538462, Blast_Score=240, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=36.144578313253, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74647; Mature: 74647

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFANTDLQHLLFGRLSLEDIPFHEPILQVTFAGVAVAGIAVIAAITYFRFWGPLWRDWLT
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SVDHKKIGIMYVVLALVMLLRGFADALLMRSQQAIAFGSNEGFLPPHHYDQIFTAHGVIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
IFFVAMPFVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTVSGATTIMISLFVGEFARTGW
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCC
LAYPPLSGADMSPGVGVDYYIWGLQIAGIGTTLSGINLVATIVKMRAPGMSMMKLPIFTW
EECCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TSLCTNVLIVAAFPILAAVLALLSLDRYVGTHFFTNDLGGNPMMYFNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGVFSEVTSAFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGL
EEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TTMIISIPTGAKIFNWLFTMYRGRIRFDVPMLWTVSFMVTFTIGGMTGVLLAVPPADFVL
HHHEEECCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHEEEEEECCHHHHH
HNSLFLIAHFHNVIIGGVLFGMFAGVNYWFPKAFGFRLDEFWGKVSFWFWTIGFYVAFMP
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LYVLGLMGVTRRAQHFDDPSLQIWFVIAAIGAGLIALGIGAMIVQFAVSIKNREALRDVT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWEGRTLEWATSSPPPDYNFAFTPVVHSLDAWWDMKARGFQRPLSGYKPIHMPKNTAT
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCHH
GVILGVVSIVFSFAMIWYIWWLAALTFVAMLAITIAHTFNYNRDFYIPAETVRRTEQQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
EALAARV
HHHHHCC
>Mature Secondary Structure
MFANTDLQHLLFGRLSLEDIPFHEPILQVTFAGVAVAGIAVIAAITYFRFWGPLWRDWLT
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SVDHKKIGIMYVVLALVMLLRGFADALLMRSQQAIAFGSNEGFLPPHHYDQIFTAHGVIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
IFFVAMPFVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTVSGATTIMISLFVGEFARTGW
HHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCC
LAYPPLSGADMSPGVGVDYYIWGLQIAGIGTTLSGINLVATIVKMRAPGMSMMKLPIFTW
EECCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TSLCTNVLIVAAFPILAAVLALLSLDRYVGTHFFTNDLGGNPMMYFNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGVFSEVTSAFSGKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNSFFGL
EEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TTMIISIPTGAKIFNWLFTMYRGRIRFDVPMLWTVSFMVTFTIGGMTGVLLAVPPADFVL
HHHEEECCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHEEEEEECCHHHHH
HNSLFLIAHFHNVIIGGVLFGMFAGVNYWFPKAFGFRLDEFWGKVSFWFWTIGFYVAFMP
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LYVLGLMGVTRRAQHFDDPSLQIWFVIAAIGAGLIALGIGAMIVQFAVSIKNREALRDVT
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWEGRTLEWATSSPPPDYNFAFTPVVHSLDAWWDMKARGFQRPLSGYKPIHMPKNTAT
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCHH
GVILGVVSIVFSFAMIWYIWWLAALTFVAMLAITIAHTFNYNRDFYIPAETVRRTEQQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
EALAARV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]