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The map label for this gene is serS

Identifier: 218532490

GI number: 218532490

Start: 4881281

End: 4882567

Strand: Reverse

Name: serS

Synonym: Mchl_4604

Alternate gene names: 218532490

Gene position: 4882567-4881281 (Counterclockwise)

Preceding gene: 218532491

Following gene: 218532489

Centisome position: 84.5

GC content: 68.84

Gene sequence:

>1287_bases
ATGCACGACATCCGCGCCATCCGCGAGAACCCGGAGGCCTTCGACCGCGACCTGGAGCGGCGTGGCCTCGCGCCCCTCAG
CGCCGAGCTGATCGCCCTCGACGACGTGCGCAAGGGTGCGGTCTCGGCCGCACAGGCGGCCCAGGAGCGGCGCAACGCGC
TGTCCAAGGAGATCGGCGCCGCCAAGAAGGCCAAGGACGAGGCCCGTGCGACCGAGCTGATGGCCGAGGTCGCCCGCCTG
AAGGAAGAGGCACCGGGCCTCGAAGCCGCGCAGGGGGAGGCCGCCAAGGCCCTCGACGAGCGTCTCGCCGCGATCCCGAA
CCGTCCGAAGGACGACGTGCCCCCCGGCGCCGACGAGCACGGCAATGTCGAGTACCGCCGCTTCGATTCCTCCCGTGAGC
GCCTGACGCAAGGGCGTCAGCATTTCGAGCTCGGCGAGGCCACCGGGCTGATGGATTTCGAGGCGGCCGCGAAACTCTCC
GGCTCGCGCTTCGTCGTGCTGAAGGGCCAGCTCGCCCGGCTGGAGCGGGCGCTCGGCCAGTTCATGCTCGACCTGCACAC
GGGCGAGCACGGCTATACCGAGGTGGTGCCGCCGGTCCTCGTGCGTGAGGAAGCGATGTTCGGCACGGCGCAATTGCCGA
AGTTCCGTGATGATCAGTTCGCGGCGGGCGAGAACTTCTGGCTGATCCCCACGGCGGAAGTCCCGCTCACCAACCTCGTG
CGCGAAAGCATCCTCGCGGAGGACGAGCTTCCCTTGCGCTTCACCGCGCTCACCCCCTGCTTCCGCGCGGAGGCCGGGGC
GGCGGGGCGCGACACCCGCGGCATGCTGCGCCAGCACCAGTTCAACAAGGTCGAGCTGGTCTCGATCACCGCACCCGAAA
AGTCGGCCGAGGAGCACGAGCGGATGCTCGCCTGCGCCGAGGCCGTGCTGCAGAAGCTCGATCTCACCTATCGCGTCATG
ACGCTGTGTACCGGTGACATGGGCTTTGCCTCCCAGAAAACCTACGACATCGAGGTCTGGGTGCCGGGCCAGCAGACATA
CCGCGAGATTTCGTCCTGCTCGGTCTGCGGCGAGTTCCAGGCGCGGCGGATGAATGCGCGCTACCGGGCCAAGGAGGGCA
GGGGGGTCGGCTTCGTCCACACCCTGAACGGCTCGGGCGTCGCGGTCGGCCGCGCGCTGATCGCCGTGATGGAGAACTAC
CAGAACCCCGACGGCAGCGTCACGATCCCGTCGGCGCTCCAGCCCTACATGGGCGGCCTCACCCGGATCGAGGGACCGAA
GAACTGA

Upstream 100 bases:

>100_bases
GCCTCGGCCCGAGCGCCTGCCGAAGCGCCTGCTCTTGTGATGCCGAGGGCGATGCGGCAAAGCGGGGCCCTCGCGCGCAC
AAGACCTCAAGAGCCCCGAA

Downstream 100 bases:

>100_bases
TGCGCATCCTGGTCACCAACGACGACGGCATCCACGCGCCGGGCCTGGAGACGCTGGAAGGCATCGCCCGCGCGCTCAGC
GACGATGTCTGGGTGGTCGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MHDIRAIRENPEAFDRDLERRGLAPLSAELIALDDVRKGAVSAAQAAQERRNALSKEIGAAKKAKDEARATELMAEVARL
KEEAPGLEAAQGEAAKALDERLAAIPNRPKDDVPPGADEHGNVEYRRFDSSRERLTQGRQHFELGEATGLMDFEAAAKLS
GSRFVVLKGQLARLERALGQFMLDLHTGEHGYTEVVPPVLVREEAMFGTAQLPKFRDDQFAAGENFWLIPTAEVPLTNLV
RESILAEDELPLRFTALTPCFRAEAGAAGRDTRGMLRQHQFNKVELVSITAPEKSAEEHERMLACAEAVLQKLDLTYRVM
TLCTGDMGFASQKTYDIEVWVPGQQTYREISSCSVCGEFQARRMNARYRAKEGRGVGFVHTLNGSGVAVGRALIAVMENY
QNPDGSVTIPSALQPYMGGLTRIEGPKN

Sequences:

>Translated_428_residues
MHDIRAIRENPEAFDRDLERRGLAPLSAELIALDDVRKGAVSAAQAAQERRNALSKEIGAAKKAKDEARATELMAEVARL
KEEAPGLEAAQGEAAKALDERLAAIPNRPKDDVPPGADEHGNVEYRRFDSSRERLTQGRQHFELGEATGLMDFEAAAKLS
GSRFVVLKGQLARLERALGQFMLDLHTGEHGYTEVVPPVLVREEAMFGTAQLPKFRDDQFAAGENFWLIPTAEVPLTNLV
RESILAEDELPLRFTALTPCFRAEAGAAGRDTRGMLRQHQFNKVELVSITAPEKSAEEHERMLACAEAVLQKLDLTYRVM
TLCTGDMGFASQKTYDIEVWVPGQQTYREISSCSVCGEFQARRMNARYRAKEGRGVGFVHTLNGSGVAVGRALIAVMENY
QNPDGSVTIPSALQPYMGGLTRIEGPKN
>Mature_428_residues
MHDIRAIRENPEAFDRDLERRGLAPLSAELIALDDVRKGAVSAAQAAQERRNALSKEIGAAKKAKDEARATELMAEVARL
KEEAPGLEAAQGEAAKALDERLAAIPNRPKDDVPPGADEHGNVEYRRFDSSRERLTQGRQHFELGEATGLMDFEAAAKLS
GSRFVVLKGQLARLERALGQFMLDLHTGEHGYTEVVPPVLVREEAMFGTAQLPKFRDDQFAAGENFWLIPTAEVPLTNLV
RESILAEDELPLRFTALTPCFRAEAGAAGRDTRGMLRQHQFNKVELVSITAPEKSAEEHERMLACAEAVLQKLDLTYRVM
TLCTGDMGFASQKTYDIEVWVPGQQTYREISSCSVCGEFQARRMNARYRAKEGRGVGFVHTLNGSGVAVGRALIAVMENY
QNPDGSVTIPSALQPYMGGLTRIEGPKN

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=336, Percent_Identity=34.5238095238095, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI225579074, Length=331, Percent_Identity=32.6283987915408, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI8923421, Length=331, Percent_Identity=32.6283987915408, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787120, Length=434, Percent_Identity=52.3041474654378, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17539260, Length=452, Percent_Identity=31.6371681415929, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=308, Percent_Identity=30.8441558441558, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321799, Length=366, Percent_Identity=31.1475409836066, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320226, Length=388, Percent_Identity=30.9278350515464, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=30.8855291576674, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17737985, Length=276, Percent_Identity=35.8695652173913, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_METC4 (B7KPY5)

Other databases:

- EMBL:   CP001298
- RefSeq:   YP_002423306.1
- ProteinModelPortal:   B7KPY5
- SMR:   B7KPY5
- GeneID:   7118000
- GenomeReviews:   CP001298_GR
- KEGG:   mch:Mchl_4604
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47121; Mature: 47121

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRAIRENPEAFDRDLERRGLAPLSAELIALDDVRKGAVSAAQAAQERRNALSKEIGA
CCCCHHHHCCHHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAKDEARATELMAEVARLKEEAPGLEAAQGEAAKALDERLAAIPNRPKDDVPPGADEH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GNVEYRRFDSSRERLTQGRQHFELGEATGLMDFEAAAKLSGSRFVVLKGQLARLERALGQ
CCEEEEECCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHH
FMLDLHTGEHGYTEVVPPVLVREEAMFGTAQLPKFRDDQFAAGENFWLIPTAEVPLTNLV
HHHHHCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
RESILAEDELPLRFTALTPCFRAEAGAAGRDTRGMLRQHQFNKVELVSITAPEKSAEEHE
HHHHHCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHH
RMLACAEAVLQKLDLTYRVMTLCTGDMGFASQKTYDIEVWVPGQQTYREISSCSVCGEFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
ARRMNARYRAKEGRGVGFVHTLNGSGVAVGRALIAVMENYQNPDGSVTIPSALQPYMGGL
HHHHCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHCCC
TRIEGPKN
CCCCCCCC
>Mature Secondary Structure
MHDIRAIRENPEAFDRDLERRGLAPLSAELIALDDVRKGAVSAAQAAQERRNALSKEIGA
CCCCHHHHCCHHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAKDEARATELMAEVARLKEEAPGLEAAQGEAAKALDERLAAIPNRPKDDVPPGADEH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GNVEYRRFDSSRERLTQGRQHFELGEATGLMDFEAAAKLSGSRFVVLKGQLARLERALGQ
CCEEEEECCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHH
FMLDLHTGEHGYTEVVPPVLVREEAMFGTAQLPKFRDDQFAAGENFWLIPTAEVPLTNLV
HHHHHCCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHH
RESILAEDELPLRFTALTPCFRAEAGAAGRDTRGMLRQHQFNKVELVSITAPEKSAEEHE
HHHHHCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHH
RMLACAEAVLQKLDLTYRVMTLCTGDMGFASQKTYDIEVWVPGQQTYREISSCSVCGEFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
ARRMNARYRAKEGRGVGFVHTLNGSGVAVGRALIAVMENYQNPDGSVTIPSALQPYMGGL
HHHHCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHCCC
TRIEGPKN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA