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The map label for this gene is zraS [C]

Identifier: 218532363

GI number: 218532363

Start: 4737488

End: 4739251

Strand: Reverse

Name: zraS [C]

Synonym: Mchl_4475

Alternate gene names: 218532363

Gene position: 4739251-4737488 (Counterclockwise)

Preceding gene: 218532364

Following gene: 218532362

Centisome position: 82.02

GC content: 71.32

Gene sequence:

>1764_bases
ATGAGCACTGAGCCCGACGCCACGGCTTTGGACGAGGCGCAAGCGCGCATCCGCGCGCTGGAAACGCGGTTGGAGGAGGT
CGAGGACACCCTGGCGGCGATCCGCCGGGGCGATTTCGATGCGATCGTGGTCGAGGGACCGAGCGGCGAGCGGCTGGTCT
ACACCCTGGAGAATGCCGACCGGCCCTACCGGGTGCTGATCGAGCAGATCCAGGAGGGGGCCTTCACCCTCGGGCCGGAT
GGAACGCTGCTCTACTGCAACCGCCGGCTCGCCGAGACCCTGGGCACTCCACAGGAGCGCCTGATCGGCCAGCCCTTCGC
GCGCTTCGCCGCCGGGGGCCAGGACGCGGCGCTCGCCGCCCTGATCACGCAGGCGGCGCGGATGCCGGCCCGCGGCGAGA
TCGCCCTGTGCGACGAGGCGGGGGTCGAGCGCCCGGCCTACCTGTCGCTGAACCGCCTCGACGGCGACGGCGACACCCTG
CTCCTTTGCGGCGTGATCACCGACCTCACGGCGGAGCGGCTGCGCCTGCACGAACTCGCCGAGGCTAACGAGCGCCTGCG
CGCCGAGGTGGCCGAGCGCGAGCGGATCGAGGAGGCATTGCGCCAGAGCCAGAAGATGGAGGCGGTGGGCCAGCTCACCG
GCGGCGTCGCGCACGACTTCAACAACCTGCTCACCGTCATCAAGTCCTCCACCGACCTGCTCAAGCGCCCCGATCTCGCC
GAGGAGCGCCGCCGCCGCTATGTCGACGCCATCTCCGACACGGTGGCACGGGCGGCCAAGCTGACCGGCCAGCTCCTCGC
CTTCGCCCGGCGCCAAGCCTTGAAGCCCGAGGTGTTCGATGCCGGCCGCGGCGTCGCGTCGGTGGCCGACATGGTCGGCA
CGCTCACCGGCGCGCGCATCCAGGTGAAGACCTTGATCGAGCCCTGTTTCGACGCCGCGGGCGAGCCCTTCGCCTGCCTC
GTGGAGGCCGATCCGAGCCAGTTCGACACAGCGCTCGTCAACATGGTCGTCAACGCCCGCGACGCCATGGACGGCGAGGG
CACGCTCACCATCCGCGTCGGCCATGCCGGGCAAATTCCGGCCCTGCGCACCCATCCGGCCGTGCCCGGCGACTTCGTGG
CGGTGGCGATTTCCGACACGGGGACGGGCATCGCGCCCGCCGACCTGTCGCGGATCTTCGAGCCGTTCTTCACGACGAAG
GGCGTCGGCCAGGGCACCGGGCTCGGGCTGTCCCAGGTGTTCGGCTTCGCCAAGCAATCGGGCGGCGACATCGCGGTGGA
GAGCGTGCTGGGACAGGGCACGACCTTCACCCTGTTCCTGCCGCGGGCCAAGGTCGCCCCGACGATGGTCGAGTCCGCCG
ACGAGCCCGAGCCGCTGGCCCCCGGCCACGGCACCTGCGTGCTTCTCGTCGAGGACAACCGCGAGGTCGGCGCCTTCGCG
ACGCAGGCGCTGGCCGAACTCGGCTACGGCACCGTCTGGGCGATGGATGCGGAGCAGGCGCTGGCCGAACTCGACCGGAC
GCCGGAGCGCTTCGACGTGGTGTTCACCGACGTGGTGATGCCCGGCATGAACGGGGTCGAACTCGCCCGCACGATCCTGG
GGCGGACGCCGGGCATGCCGATCGTGCTCTCCTCCGGCTACAGCCACGTGCTGGCCGAGGACGGGCACCACGGCTTCCCG
CTGCTGCACAAGCCCTACTCGGTGGAGGATCTCTCGCGCATCCTGCGCCGGGCGATCCAGCGGCGCGCCGCGCGGGCGCG
GTGA

Upstream 100 bases:

>100_bases
TCACCCCTCCCCGCCCGGCGCATCACCGGAGATCTGAGCGACGAGCGGCATGTCCTCGACGGGCTTGGACTCGGCGGGCT
CGGATTCGGCGGGGCCGCCG

Downstream 100 bases:

>100_bases
TTGTCCCTTCGCCCGCGGCGGCTTGCGCGGCGGGCAAGAAAAAAGGCTCGGATTGCTCCGAGCCTTGAAGGGAAAAGGCC
ATTGGGGGCTGAACTGGCCT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MSTEPDATALDEAQARIRALETRLEEVEDTLAAIRRGDFDAIVVEGPSGERLVYTLENADRPYRVLIEQIQEGAFTLGPD
GTLLYCNRRLAETLGTPQERLIGQPFARFAAGGQDAALAALITQAARMPARGEIALCDEAGVERPAYLSLNRLDGDGDTL
LLCGVITDLTAERLRLHELAEANERLRAEVAERERIEEALRQSQKMEAVGQLTGGVAHDFNNLLTVIKSSTDLLKRPDLA
EERRRRYVDAISDTVARAAKLTGQLLAFARRQALKPEVFDAGRGVASVADMVGTLTGARIQVKTLIEPCFDAAGEPFACL
VEADPSQFDTALVNMVVNARDAMDGEGTLTIRVGHAGQIPALRTHPAVPGDFVAVAISDTGTGIAPADLSRIFEPFFTTK
GVGQGTGLGLSQVFGFAKQSGGDIAVESVLGQGTTFTLFLPRAKVAPTMVESADEPEPLAPGHGTCVLLVEDNREVGAFA
TQALAELGYGTVWAMDAEQALAELDRTPERFDVVFTDVVMPGMNGVELARTILGRTPGMPIVLSSGYSHVLAEDGHHGFP
LLHKPYSVEDLSRILRRAIQRRAARAR

Sequences:

>Translated_587_residues
MSTEPDATALDEAQARIRALETRLEEVEDTLAAIRRGDFDAIVVEGPSGERLVYTLENADRPYRVLIEQIQEGAFTLGPD
GTLLYCNRRLAETLGTPQERLIGQPFARFAAGGQDAALAALITQAARMPARGEIALCDEAGVERPAYLSLNRLDGDGDTL
LLCGVITDLTAERLRLHELAEANERLRAEVAERERIEEALRQSQKMEAVGQLTGGVAHDFNNLLTVIKSSTDLLKRPDLA
EERRRRYVDAISDTVARAAKLTGQLLAFARRQALKPEVFDAGRGVASVADMVGTLTGARIQVKTLIEPCFDAAGEPFACL
VEADPSQFDTALVNMVVNARDAMDGEGTLTIRVGHAGQIPALRTHPAVPGDFVAVAISDTGTGIAPADLSRIFEPFFTTK
GVGQGTGLGLSQVFGFAKQSGGDIAVESVLGQGTTFTLFLPRAKVAPTMVESADEPEPLAPGHGTCVLLVEDNREVGAFA
TQALAELGYGTVWAMDAEQALAELDRTPERFDVVFTDVVMPGMNGVELARTILGRTPGMPIVLSSGYSHVLAEDGHHGFP
LLHKPYSVEDLSRILRRAIQRRAARAR
>Mature_586_residues
STEPDATALDEAQARIRALETRLEEVEDTLAAIRRGDFDAIVVEGPSGERLVYTLENADRPYRVLIEQIQEGAFTLGPDG
TLLYCNRRLAETLGTPQERLIGQPFARFAAGGQDAALAALITQAARMPARGEIALCDEAGVERPAYLSLNRLDGDGDTLL
LCGVITDLTAERLRLHELAEANERLRAEVAERERIEEALRQSQKMEAVGQLTGGVAHDFNNLLTVIKSSTDLLKRPDLAE
ERRRRYVDAISDTVARAAKLTGQLLAFARRQALKPEVFDAGRGVASVADMVGTLTGARIQVKTLIEPCFDAAGEPFACLV
EADPSQFDTALVNMVVNARDAMDGEGTLTIRVGHAGQIPALRTHPAVPGDFVAVAISDTGTGIAPADLSRIFEPFFTTKG
VGQGTGLGLSQVFGFAKQSGGDIAVESVLGQGTTFTLFLPRAKVAPTMVESADEPEPLAPGHGTCVLLVEDNREVGAFAT
QALAELGYGTVWAMDAEQALAELDRTPERFDVVFTDVVMPGMNGVELARTILGRTPGMPIVLSSGYSHVLAEDGHHGFPL
LHKPYSVEDLSRILRRAIQRRAARAR

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=256, Percent_Identity=26.953125, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788713, Length=417, Percent_Identity=24.7002398081535, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=28.740157480315, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI48994928, Length=402, Percent_Identity=24.8756218905473, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081816, Length=265, Percent_Identity=29.811320754717, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=311, Percent_Identity=24.4372990353698, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63126; Mature: 62995

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPDATALDEAQARIRALETRLEEVEDTLAAIRRGDFDAIVVEGPSGERLVYTLENAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCC
RPYRVLIEQIQEGAFTLGPDGTLLYCNRRLAETLGTPQERLIGQPFARFAAGGQDAALAA
CHHHHHHHHHHCCCEEECCCCCEEEECHHHHHHHCCCHHHHCCCCHHHHHCCCCHHHHHH
LITQAARMPARGEIALCDEAGVERPAYLSLNRLDGDGDTLLLCGVITDLTAERLRLHELA
HHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHH
EANERLRAEVAERERIEEALRQSQKMEAVGQLTGGVAHDFNNLLTVIKSSTDLLKRPDLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHCCCHH
EERRRRYVDAISDTVARAAKLTGQLLAFARRQALKPEVFDAGRGVASVADMVGTLTGARI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCEE
QVKTLIEPCFDAAGEPFACLVEADPSQFDTALVNMVVNARDAMDGEGTLTIRVGHAGQIP
EHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
ALRTHPAVPGDFVAVAISDTGTGIAPADLSRIFEPFFTTKGVGQGTGLGLSQVFGFAKQS
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
GGDIAVESVLGQGTTFTLFLPRAKVAPTMVESADEPEPLAPGHGTCVLLVEDNREVGAFA
CCCEEHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHH
TQALAELGYGTVWAMDAEQALAELDRTPERFDVVFTDVVMPGMNGVELARTILGRTPGMP
HHHHHHCCCCEEEEECHHHHHHHHHCCCHHHHEEEEHHHCCCCCHHHHHHHHHCCCCCCC
IVLSSGYSHVLAEDGHHGFPLLHKPYSVEDLSRILRRAIQRRAARAR
EEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STEPDATALDEAQARIRALETRLEEVEDTLAAIRRGDFDAIVVEGPSGERLVYTLENAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCC
RPYRVLIEQIQEGAFTLGPDGTLLYCNRRLAETLGTPQERLIGQPFARFAAGGQDAALAA
CHHHHHHHHHHCCCEEECCCCCEEEECHHHHHHHCCCHHHHCCCCHHHHHCCCCHHHHHH
LITQAARMPARGEIALCDEAGVERPAYLSLNRLDGDGDTLLLCGVITDLTAERLRLHELA
HHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHH
EANERLRAEVAERERIEEALRQSQKMEAVGQLTGGVAHDFNNLLTVIKSSTDLLKRPDLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHCCCHH
EERRRRYVDAISDTVARAAKLTGQLLAFARRQALKPEVFDAGRGVASVADMVGTLTGARI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCEE
QVKTLIEPCFDAAGEPFACLVEADPSQFDTALVNMVVNARDAMDGEGTLTIRVGHAGQIP
EHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
ALRTHPAVPGDFVAVAISDTGTGIAPADLSRIFEPFFTTKGVGQGTGLGLSQVFGFAKQS
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
GGDIAVESVLGQGTTFTLFLPRAKVAPTMVESADEPEPLAPGHGTCVLLVEDNREVGAFA
CCCEEHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHH
TQALAELGYGTVWAMDAEQALAELDRTPERFDVVFTDVVMPGMNGVELARTILGRTPGMP
HHHHHHCCCCEEEEECHHHHHHHHHCCCHHHHEEEEHHHCCCCCHHHHHHHHHCCCCCCC
IVLSSGYSHVLAEDGHHGFPLLHKPYSVEDLSRILRRAIQRRAARAR
EEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA