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The map label for this gene is uvrB [H]

Identifier: 218532313

GI number: 218532313

Start: 4682386

End: 4685136

Strand: Reverse

Name: uvrB [H]

Synonym: Mchl_4425

Alternate gene names: 218532313

Gene position: 4685136-4682386 (Counterclockwise)

Preceding gene: 218532314

Following gene: 218532312

Centisome position: 81.09

GC content: 67.83

Gene sequence:

>2751_bases
ATGCCCGCACCCAAGACACCGCGCGTGAGTCCGGCCAAAGCGCCTGCCAAAGCAACGGCCAAAGCGCCCGCCAAGGCGAC
CTCGAAGACGACGGCGAAGGCCGACCGGCCCGAGCTGATGCCGCTCGACGAGCATCTTGCCGCGCTGCTCAACCCGGCCC
TCAACCGCAACCGCCTGAAGGCGGTCGAGCCCGTGCCGGAACCGCCCCGAAAGGGACGCGGACCGAAGGGCGAGGCGAAG
GCCTACAAGAAAATCGCGCAAGACGGCTTCGCCGAGGCGCCGCAGGCGGGCTTCGCCATCGGCGACGCGGCCGACGTCGA
TCCGCGGCTGGCCCAGGCGCTCGGCCTCGTCCCGCCCGACGACGGCCCGGCACCGGAAACCGCGCCCGATGGCGAGACGC
CCTCGCTTGCCACAGAGGGCGTGTCGGCCACGGTCGAGGCGCTGGAGCGGCTGCTCGTCGAGGGCAACCCGCTGTTCAAG
AACGGCGAGGCCTGGGTGCCGCACAGGCCCGAGCGCCCGGCCAAGTCGGAGGGCGGCGTGAAGTTCACGCTGAAATCCGA
GTTCACGCCCGCCGGTGACCAGCCCACCGCCATCGCCGCCCTGGTCGAGGGCGTCCGGACGGCCGAGCGCGATCAGGTGC
TGCTCGGCGTCACCGGCTCGGGAAAAACCTTCACGATGGCCAAGGTCATCGAGGAGACGCAGCGCCCGGCCCTGATCCTG
GCGCCCAACAAGACGCTGGCGGCGCAGCTCTACGGCGAGTTCAAGAGCTTTTTCCCGGACAACGCGGTCGAGTACTTCGT
CTCGTATTACGACTATTACCAGCCCGAGGCCTACGTGCCCCGGTCCGATACCTTCATCGAGAAGGAAAGCTCGATCAACG
AGCAGATCGACCGGATGCGGCACTCGGCCACCCGCGCCCTGCTGGAGCGGGACGACGTCATCATCGTCGCCTCGGTCTCA
TGCATCTACGGTATCGGCTCGGTCGAGACCTACACGGCGATGTCGTTCACGGTGTCGCTCGGCGAGCGGATCGAGCAGCG
CCAGCTCATCGCCGACCTCGTGGCCCTTCAGTACAAGCGCATCCAGTCGGACTTCGCCCGCGGCACCTTCCGGGTGCGCG
GCGACGTGATCGAGCTGTGGCCGGCCCACTTGGAGGATCGCGGCTGGCGCATCGGCCTGTTCGGCGACGAGATCGAATCC
ATCGTCGAGTTCGATCCGCTGACGGGCAAGAAGCTCAACGAGCTGAAGTTCGTCAAAGTCTACGCGAACTCGCACTACGT
CACGCCGCGCCCCACCCTCCAGCAGGCGATCAAGGGCATCAAAACTGAGCTCAAGCTCCGCGTCGAGGAGTTGACCCGGA
TGGGCCGCCTCATCGAGGCGCAGCGGCTGGAGCAGCGCTGCACCTTCGACATCGAGATGATCGAGGCGACCGGCGCCTGC
AACGGCATCGAAAATTATTCGCGCTACCTCACCGGCCGCAAGCCCGGCGAGCCGCCGCCGACCCTGTTCGAGTACCTGCC
CGACAACGCCCTCGTCTTCACCGACGAGAGCCACGTCACGGTTCCGCAGATCGGCGGCATGTACAAGGGCGACTTCCGCC
GCAAGGCGACGCTGGCCGAGTACGGCTTCCGCCTGCCCTCCTGCCTCGACAACCGCCCGCTGCGGTTCGAGGAATGGGAC
GCGATGCGCCCGCAATCGGTCCACGTCTCGGCGACCCCGGCCAAGTGGGAGATGGAGCGCACGGCCGGCGTCTTCGCCGA
GCAGGTCATCCGCCCCACCGGCCTGGTCGATCCGGTGATCGAGATCCGCCCGGCCCGCTCCCAGGTCGACGACTTGCTGG
GCGAAGTCCGCGAAGTCGCTCAGGCCGGCTACCGCACCCTGGTGACCACGCTGACCAAGCGCATGGCCGAGGATCTCACC
GAGTACCTGCACGAGAACTCGGTGCGGGTGCGCTACATGCACTCCGACATCGACACCCTGGAGCGCATCGAGATTATTCG
CGACCTGCGCCTCGGCGCCTTCGACGTGCTGATCGGCATCAACCTCCTGCGCGAAGGTCTCGACATCCCCGAATGCGCGC
TGGTCGCCATTCTCGATGCCGACAAGGAAGGGTTTCTGCGCTCCGAGACCTCGCTGATCCAGACCATCGGCCGCGCGGCC
CGCAACGCCGATGCCCGCTGCATCCTCTATGCGGACAACATCACCGGCTCGATGGAGCGGGCGATGGCCGAGACCGAGCG
GCGCCGCCAGAAGCAGCTCGCCTACAACGAGGAACACGGCATCACGCCGCAATCGGTCAAGCGCGGCATCAGCGACATCC
TCGAGAGCGTGTACGAGCGCGACCACGTCCGCGTCGATACGGGGCTGGCCAAAGACGCGATCACCGTCGGCCACAACCTC
AAGGCGGTGATGGCCGACCTCGAAAAGCGCATGCGCGCCGCCGCCGCCGACCTCGACTTCGAGGAGGCCGCGCGGCTTCG
CGACGAGCTCAAGCGCCTCCAGGCGACCGAACTCATGGTCTCCGACGATCCCATGGCCCGGCAGGGCGACATCGAGCGCG
AGGCCGGCCGCTACGGGCAGAAGGGCAGCCGCATCTCGAAGCCCACCCTCGACAATATGGGCCCGGGCACCGACCGCGAA
CTCCCGGCCGACGCCGTGCCTTGGCAGGAGCGGCCGAAGGCGCGCTCGACGCAAGGACTCGGCGGCCAGAAGCCCCGCTA
CAAGGGGGGCGGCGGACGCAAGCGAGGGTGA

Upstream 100 bases:

>100_bases
TTGTCCCGAAGCCGGTCTGGCCCAAAACGGCTGCAAGCCGGGACAATCTTGGGCCGTTCGGACTCTTCCGGAGACCGCCC
GACGGGCCCATATTGCCGCC

Downstream 100 bases:

>100_bases
GGGCGCGCGACGGCGGAACCTCGGCCGTCGCCTGCGATTGGCTCTTCAGATCCTGCAACCGTCGGTCCGCTCCGCCGTGA
GCCCGGCCGGCGGCGCCAAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 916; Mature: 915

Protein sequence:

>916_residues
MPAPKTPRVSPAKAPAKATAKAPAKATSKTTAKADRPELMPLDEHLAALLNPALNRNRLKAVEPVPEPPRKGRGPKGEAK
AYKKIAQDGFAEAPQAGFAIGDAADVDPRLAQALGLVPPDDGPAPETAPDGETPSLATEGVSATVEALERLLVEGNPLFK
NGEAWVPHRPERPAKSEGGVKFTLKSEFTPAGDQPTAIAALVEGVRTAERDQVLLGVTGSGKTFTMAKVIEETQRPALIL
APNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPRSDTFIEKESSINEQIDRMRHSATRALLERDDVIIVASVS
CIYGIGSVETYTAMSFTVSLGERIEQRQLIADLVALQYKRIQSDFARGTFRVRGDVIELWPAHLEDRGWRIGLFGDEIES
IVEFDPLTGKKLNELKFVKVYANSHYVTPRPTLQQAIKGIKTELKLRVEELTRMGRLIEAQRLEQRCTFDIEMIEATGAC
NGIENYSRYLTGRKPGEPPPTLFEYLPDNALVFTDESHVTVPQIGGMYKGDFRRKATLAEYGFRLPSCLDNRPLRFEEWD
AMRPQSVHVSATPAKWEMERTAGVFAEQVIRPTGLVDPVIEIRPARSQVDDLLGEVREVAQAGYRTLVTTLTKRMAEDLT
EYLHENSVRVRYMHSDIDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSETSLIQTIGRAA
RNADARCILYADNITGSMERAMAETERRRQKQLAYNEEHGITPQSVKRGISDILESVYERDHVRVDTGLAKDAITVGHNL
KAVMADLEKRMRAAAADLDFEEAARLRDELKRLQATELMVSDDPMARQGDIEREAGRYGQKGSRISKPTLDNMGPGTDRE
LPADAVPWQERPKARSTQGLGGQKPRYKGGGGRKRG

Sequences:

>Translated_916_residues
MPAPKTPRVSPAKAPAKATAKAPAKATSKTTAKADRPELMPLDEHLAALLNPALNRNRLKAVEPVPEPPRKGRGPKGEAK
AYKKIAQDGFAEAPQAGFAIGDAADVDPRLAQALGLVPPDDGPAPETAPDGETPSLATEGVSATVEALERLLVEGNPLFK
NGEAWVPHRPERPAKSEGGVKFTLKSEFTPAGDQPTAIAALVEGVRTAERDQVLLGVTGSGKTFTMAKVIEETQRPALIL
APNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPRSDTFIEKESSINEQIDRMRHSATRALLERDDVIIVASVS
CIYGIGSVETYTAMSFTVSLGERIEQRQLIADLVALQYKRIQSDFARGTFRVRGDVIELWPAHLEDRGWRIGLFGDEIES
IVEFDPLTGKKLNELKFVKVYANSHYVTPRPTLQQAIKGIKTELKLRVEELTRMGRLIEAQRLEQRCTFDIEMIEATGAC
NGIENYSRYLTGRKPGEPPPTLFEYLPDNALVFTDESHVTVPQIGGMYKGDFRRKATLAEYGFRLPSCLDNRPLRFEEWD
AMRPQSVHVSATPAKWEMERTAGVFAEQVIRPTGLVDPVIEIRPARSQVDDLLGEVREVAQAGYRTLVTTLTKRMAEDLT
EYLHENSVRVRYMHSDIDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSETSLIQTIGRAA
RNADARCILYADNITGSMERAMAETERRRQKQLAYNEEHGITPQSVKRGISDILESVYERDHVRVDTGLAKDAITVGHNL
KAVMADLEKRMRAAAADLDFEEAARLRDELKRLQATELMVSDDPMARQGDIEREAGRYGQKGSRISKPTLDNMGPGTDRE
LPADAVPWQERPKARSTQGLGGQKPRYKGGGGRKRG
>Mature_915_residues
PAPKTPRVSPAKAPAKATAKAPAKATSKTTAKADRPELMPLDEHLAALLNPALNRNRLKAVEPVPEPPRKGRGPKGEAKA
YKKIAQDGFAEAPQAGFAIGDAADVDPRLAQALGLVPPDDGPAPETAPDGETPSLATEGVSATVEALERLLVEGNPLFKN
GEAWVPHRPERPAKSEGGVKFTLKSEFTPAGDQPTAIAALVEGVRTAERDQVLLGVTGSGKTFTMAKVIEETQRPALILA
PNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPRSDTFIEKESSINEQIDRMRHSATRALLERDDVIIVASVSC
IYGIGSVETYTAMSFTVSLGERIEQRQLIADLVALQYKRIQSDFARGTFRVRGDVIELWPAHLEDRGWRIGLFGDEIESI
VEFDPLTGKKLNELKFVKVYANSHYVTPRPTLQQAIKGIKTELKLRVEELTRMGRLIEAQRLEQRCTFDIEMIEATGACN
GIENYSRYLTGRKPGEPPPTLFEYLPDNALVFTDESHVTVPQIGGMYKGDFRRKATLAEYGFRLPSCLDNRPLRFEEWDA
MRPQSVHVSATPAKWEMERTAGVFAEQVIRPTGLVDPVIEIRPARSQVDDLLGEVREVAQAGYRTLVTTLTKRMAEDLTE
YLHENSVRVRYMHSDIDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSETSLIQTIGRAAR
NADARCILYADNITGSMERAMAETERRRQKQLAYNEEHGITPQSVKRGISDILESVYERDHVRVDTGLAKDAITVGHNLK
AVMADLEKRMRAAAADLDFEEAARLRDELKRLQATELMVSDDPMARQGDIEREAGRYGQKGSRISKPTLDNMGPGTDREL
PADAVPWQERPKARSTQGLGGQKPRYKGGGGRKRG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=677, Percent_Identity=58.0502215657312, Blast_Score=777, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 101613; Mature: 101481

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPKTPRVSPAKAPAKATAKAPAKATSKTTAKADRPELMPLDEHLAALLNPALNRNRLK
CCCCCCCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
AVEPVPEPPRKGRGPKGEAKAYKKIAQDGFAEAPQAGFAIGDAADVDPRLAQALGLVPPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHCCCCCC
DGPAPETAPDGETPSLATEGVSATVEALERLLVEGNPLFKNGEAWVPHRPERPAKSEGGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCE
KFTLKSEFTPAGDQPTAIAALVEGVRTAERDQVLLGVTGSGKTFTMAKVIEETQRPALIL
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHCCCEEEE
APNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPRSDTFIEKESSINEQIDRMR
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
HSATRALLERDDVIIVASVSCIYGIGSVETYTAMSFTVSLGERIEQRQLIADLVALQYKR
HHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQSDFARGTFRVRGDVIELWPAHLEDRGWRIGLFGDEIESIVEFDPLTGKKLNELKFVKV
HHHHHHCCEEEEECCHHHHCCHHHCCCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEEE
YANSHYVTPRPTLQQAIKGIKTELKLRVEELTRMGRLIEAQRLEQRCTFDIEMIEATGAC
EECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NGIENYSRYLTGRKPGEPPPTLFEYLPDNALVFTDESHVTVPQIGGMYKGDFRRKATLAE
CCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCEEHHCCCCCCCCCHHHHHHHHH
YGFRLPSCLDNRPLRFEEWDAMRPQSVHVSATPAKWEMERTAGVFAEQVIRPTGLVDPVI
HCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
EIRPARSQVDDLLGEVREVAQAGYRTLVTTLTKRMAEDLTEYLHENSVRVRYMHSDIDTL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
ERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSETSLIQTIGRAA
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
RNADARCILYADNITGSMERAMAETERRRQKQLAYNEEHGITPQSVKRGISDILESVYER
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
DHVRVDTGLAKDAITVGHNLKAVMADLEKRMRAAAADLDFEEAARLRDELKRLQATELMV
CCEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEE
SDDPMARQGDIEREAGRYGQKGSRISKPTLDNMGPGTDRELPADAVPWQERPKARSTQGL
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGQKPRYKGGGGRKRG
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAPKTPRVSPAKAPAKATAKAPAKATSKTTAKADRPELMPLDEHLAALLNPALNRNRLK
CCCCCCCCCCCCCCCHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
AVEPVPEPPRKGRGPKGEAKAYKKIAQDGFAEAPQAGFAIGDAADVDPRLAQALGLVPPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHCCCCCC
DGPAPETAPDGETPSLATEGVSATVEALERLLVEGNPLFKNGEAWVPHRPERPAKSEGGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCE
KFTLKSEFTPAGDQPTAIAALVEGVRTAERDQVLLGVTGSGKTFTMAKVIEETQRPALIL
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHCCCEEEE
APNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPRSDTFIEKESSINEQIDRMR
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
HSATRALLERDDVIIVASVSCIYGIGSVETYTAMSFTVSLGERIEQRQLIADLVALQYKR
HHHHHHHHCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQSDFARGTFRVRGDVIELWPAHLEDRGWRIGLFGDEIESIVEFDPLTGKKLNELKFVKV
HHHHHHCCEEEEECCHHHHCCHHHCCCCCEEEECHHHHHHHHHCCCCCCCCCCCEEEEEE
YANSHYVTPRPTLQQAIKGIKTELKLRVEELTRMGRLIEAQRLEQRCTFDIEMIEATGAC
EECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
NGIENYSRYLTGRKPGEPPPTLFEYLPDNALVFTDESHVTVPQIGGMYKGDFRRKATLAE
CCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCEEHHCCCCCCCCCHHHHHHHHH
YGFRLPSCLDNRPLRFEEWDAMRPQSVHVSATPAKWEMERTAGVFAEQVIRPTGLVDPVI
HCCCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHH
EIRPARSQVDDLLGEVREVAQAGYRTLVTTLTKRMAEDLTEYLHENSVRVRYMHSDIDTL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHH
ERIEIIRDLRLGAFDVLIGINLLREGLDIPECALVAILDADKEGFLRSETSLIQTIGRAA
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
RNADARCILYADNITGSMERAMAETERRRQKQLAYNEEHGITPQSVKRGISDILESVYER
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
DHVRVDTGLAKDAITVGHNLKAVMADLEKRMRAAAADLDFEEAARLRDELKRLQATELMV
CCEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEE
SDDPMARQGDIEREAGRYGQKGSRISKPTLDNMGPGTDRELPADAVPWQERPKARSTQGL
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGQKPRYKGGGGRKRG
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]