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The map label for this gene is coaBC [H]

Identifier: 218532183

GI number: 218532183

Start: 4535448

End: 4536740

Strand: Reverse

Name: coaBC [H]

Synonym: Mchl_4295

Alternate gene names: 218532183

Gene position: 4536740-4535448 (Counterclockwise)

Preceding gene: 218532184

Following gene: 218532182

Centisome position: 78.52

GC content: 73.09

Gene sequence:

>1293_bases
ATGTCTTCTCCGTCCCCAAAACCCCTCGCCGGCCGCCGCATCCTCCTGATCGTCGGCGGCGGCATCGCGGCTTACAAGGC
GCTCGACCTGATCCGGCGCCTGCGCGAGCGCGGGGCGCAGGTGCGGCCGCTGCTGACCGACTCAGCGCAGGAGTTCGTCA
CGCCGCTGGCCGCCGCCGCGCTGGCCGGGGAGCGGACCCATACCGACCTGTTCGACCGGGAGAGCGAGGCCGATATCGGC
CATATCAAGCTCGCCCGCGACGCCGACGCCATCGTGGTGGCGCCGGCCACCGCCAACCTGATGGCGCGGATGGCGACCGG
CCACGCGCCGGACCTCGCCTCGACGGTGCTGCTCGCCACCACCCTGCCGATCCTGATCGCCCCGGCCATGAACGTGCGGA
TGTGGCAGCATCCGGCGACACAGCGGAACCTCGCGACCCTGCAAGCCGACGGCGTCGCGGTGATCGGCCCCAACGAGGGC
GCCATGGCCGAGGCCGAGTTCGGCCCCGGGCGCCTGGCCGAGCCGCACGAGATCGCCGACGCGCTCGAAGCCCTGCTGGC
GCAGCGGTCCGAGGGCCAAGGCCTGGGATTCCTGGCCGGCCGCGAAACGCCAAAAAAACCGCTGGCGGGGCGGCACGTGC
TCGTCACCTCGGGGCCGACCCACGAGCCGATCGATCCGGTGCGCTACCTCGCCAACCGCTCCTCGGGGCGGCAGGGCCAC
GCGGTCGCCGCCGCCGCGGCCGAGGCCGGCGCCCGCGTCACCCTGGTCTCGGGGCCGGTGGCGATCCCCGATCCGGCGGG
CGTCGCCGTGGTGCGGGTCGAGAGCGCCCGCGAGATGCTCGCCGCGGTCGAGGCGGCCCTGCCCGCCGATCTCGCGATCT
TCGCCGCCGCCGTCGGCGACTGGCGCCCGGCCGAGACCCGGGCAGGCAAGATTAAGAAGGACGGCAGCACGCCCGCCCCC
CTGCAGCTCGTCGAGAACCCGGACATCCTCGCCACCATCGCCGGCCGGAGCGAAGGGCGCCCGCCCCTCGTCGTAGGCTT
TGCCGCCGAGACCGACGACGTCATCGTGAACGCGCAGAAGAAGATCGCGCGGAAGGGCTGCGACTGGATCGTCGCCAACG
ACGTCTCGGCGGAGGGCGGGGTCATGGGCGGCACCGAGAACACCGTCCACCTCGTCGCCCGCGACGGCGGCGTCGAGAGC
CGTGTCGAGACTTGGCCGAAGCTCGACAAGGAGGAGGTCGCACGGCGGCTGGTTGCGCGGTTTGCGGAATTGCTCGCGGC
GAAGTCCGCCTGA

Upstream 100 bases:

>100_bases
GGCCCTGTGGGGGATCGCGGTGGGGGCGCTGGTGCTGGCCTTTCGGTAAGAGGCCTTCTCGCACCTTGACGCGCGCCCTA
CGATTCCCCGTTCTGCCCTC

Downstream 100 bases:

>100_bases
ACATCTCCGGCTCCTCGGAGCGTATTCGCGGTTCGACAGGAGACTCTGCGGCCGTTGCGCGGCAATCATACCGCGACCGT
CCGGCGAGCGGAAATGTTCC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSSPSPKPLAGRRILLIVGGGIAAYKALDLIRRLRERGAQVRPLLTDSAQEFVTPLAAAALAGERTHTDLFDRESEADIG
HIKLARDADAIVVAPATANLMARMATGHAPDLASTVLLATTLPILIAPAMNVRMWQHPATQRNLATLQADGVAVIGPNEG
AMAEAEFGPGRLAEPHEIADALEALLAQRSEGQGLGFLAGRETPKKPLAGRHVLVTSGPTHEPIDPVRYLANRSSGRQGH
AVAAAAAEAGARVTLVSGPVAIPDPAGVAVVRVESAREMLAAVEAALPADLAIFAAAVGDWRPAETRAGKIKKDGSTPAP
LQLVENPDILATIAGRSEGRPPLVVGFAAETDDVIVNAQKKIARKGCDWIVANDVSAEGGVMGGTENTVHLVARDGGVES
RVETWPKLDKEEVARRLVARFAELLAAKSA

Sequences:

>Translated_430_residues
MSSPSPKPLAGRRILLIVGGGIAAYKALDLIRRLRERGAQVRPLLTDSAQEFVTPLAAAALAGERTHTDLFDRESEADIG
HIKLARDADAIVVAPATANLMARMATGHAPDLASTVLLATTLPILIAPAMNVRMWQHPATQRNLATLQADGVAVIGPNEG
AMAEAEFGPGRLAEPHEIADALEALLAQRSEGQGLGFLAGRETPKKPLAGRHVLVTSGPTHEPIDPVRYLANRSSGRQGH
AVAAAAAEAGARVTLVSGPVAIPDPAGVAVVRVESAREMLAAVEAALPADLAIFAAAVGDWRPAETRAGKIKKDGSTPAP
LQLVENPDILATIAGRSEGRPPLVVGFAAETDDVIVNAQKKIARKGCDWIVANDVSAEGGVMGGTENTVHLVARDGGVES
RVETWPKLDKEEVARRLVARFAELLAAKSA
>Mature_429_residues
SSPSPKPLAGRRILLIVGGGIAAYKALDLIRRLRERGAQVRPLLTDSAQEFVTPLAAAALAGERTHTDLFDRESEADIGH
IKLARDADAIVVAPATANLMARMATGHAPDLASTVLLATTLPILIAPAMNVRMWQHPATQRNLATLQADGVAVIGPNEGA
MAEAEFGPGRLAEPHEIADALEALLAQRSEGQGLGFLAGRETPKKPLAGRHVLVTSGPTHEPIDPVRYLANRSSGRQGHA
VAAAAAEAGARVTLVSGPVAIPDPAGVAVVRVESAREMLAAVEAALPADLAIFAAAVGDWRPAETRAGKIKKDGSTPAPL
QLVENPDILATIAGRSEGRPPLVVGFAAETDDVIVNAQKKIARKGCDWIVANDVSAEGGVMGGTENTVHLVARDGGVESR
VETWPKLDKEEVARRLVARFAELLAAKSA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=198, Percent_Identity=31.3131313131313, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082301, Length=391, Percent_Identity=45.0127877237852, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=182, Percent_Identity=30.2197802197802, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=28.7292817679558, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44872; Mature: 44741

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSPKPLAGRRILLIVGGGIAAYKALDLIRRLRERGAQVRPLLTDSAQEFVTPLAAAA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
LAGERTHTDLFDRESEADIGHIKLARDADAIVVAPATANLMARMATGHAPDLASTVLLAT
HCCCCCCCHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHH
TLPILIAPAMNVRMWQHPATQRNLATLQADGVAVIGPNEGAMAEAEFGPGRLAEPHEIAD
HHHHHHHCCCCCEEECCCCCCCCCEEEEECCEEEECCCCCCEEECCCCCCCCCCHHHHHH
ALEALLAQRSEGQGLGFLAGRETPKKPLAGRHVLVTSGPTHEPIDPVRYLANRSSGRQGH
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCC
AVAAAAAEAGARVTLVSGPVAIPDPAGVAVVRVESAREMLAAVEAALPADLAIFAAAVGD
CHHHHHHHCCCEEEEEECCEECCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCC
WRPAETRAGKIKKDGSTPAPLQLVENPDILATIAGRSEGRPPLVVGFAAETDDVIVNAQK
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHH
KIARKGCDWIVANDVSAEGGVMGGTENTVHLVARDGGVESRVETWPKLDKEEVARRLVAR
HHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHH
FAELLAAKSA
HHHHHHHCCC
>Mature Secondary Structure 
SSPSPKPLAGRRILLIVGGGIAAYKALDLIRRLRERGAQVRPLLTDSAQEFVTPLAAAA
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHH
LAGERTHTDLFDRESEADIGHIKLARDADAIVVAPATANLMARMATGHAPDLASTVLLAT
HCCCCCCCHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHH
TLPILIAPAMNVRMWQHPATQRNLATLQADGVAVIGPNEGAMAEAEFGPGRLAEPHEIAD
HHHHHHHCCCCCEEECCCCCCCCCEEEEECCEEEECCCCCCEEECCCCCCCCCCHHHHHH
ALEALLAQRSEGQGLGFLAGRETPKKPLAGRHVLVTSGPTHEPIDPVRYLANRSSGRQGH
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCC
AVAAAAAEAGARVTLVSGPVAIPDPAGVAVVRVESAREMLAAVEAALPADLAIFAAAVGD
CHHHHHHHCCCEEEEEECCEECCCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCC
WRPAETRAGKIKKDGSTPAPLQLVENPDILATIAGRSEGRPPLVVGFAAETDDVIVNAQK
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHH
KIARKGCDWIVANDVSAEGGVMGGTENTVHLVARDGGVESRVETWPKLDKEEVARRLVAR
HHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHH
FAELLAAKSA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]