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The map label for this gene is guaA [C]

Identifier: 218531677

GI number: 218531677

Start: 3957792

End: 3958652

Strand: Reverse

Name: guaA [C]

Synonym: Mchl_3746

Alternate gene names: 218531677

Gene position: 3958652-3957792 (Counterclockwise)

Preceding gene: 218531678

Following gene: 218531676

Centisome position: 68.51

GC content: 72.94

Gene sequence:

>861_bases
ATGACCAACGCGATGCTGCGCCTGCTGATCGCCGACGGCAACGACCGCGATGGCCGTGCGAAGCGCGAGGCCGCCGTCGG
CCAAACCACCTCGCAGGCCTTCGCCAGCGTCGTGGCCGATCTCGCGCCCGAGGTGGCCTGCACGCTGGTGAACCCGGCCG
ATGCCGAGGCCGCGATCGGATCCGATCTCGCCGGGTTCAACGGGATGGTCCTCACCGGCTCCACCCTGCGGCTGGCCGAT
GACGGTCCGGCGGTGCGGCGCCAGCTCGACCTGATGCGCGCGGCGCTGGAGGCCGGGTTGCCGGTCTTCGGCTCGTGCTG
GGGCATGCAGGTCGCCGCGGCGATCGCGGGCGGGGATGTCGGCGAGAACCCGCGCGGGCCGGAATACGGTTTCGCCCGGC
GCCTCACGGCCACGGGTGACGGGGCCGCCCACCCGCTCTTGGCCGGCCGTGCGCCCGCCTGGGATGCGCCCGCGATCCAT
CTCGATGCCGTCGTCGGCGCCCCGTCCGGCGCGCGGGTGCTTGCGGCGAACGCCATGCTCGACGTGCAGGCGATCGAGAT
CCGCTACGGGCGCGGGCTGTTCTGGGGCACGCAGTACCACCCGGAAACCGACCTCGACGAACTGGCCGCGATGCTGCGGC
TGAGCGCCGACGCGGTCGTCTCCGCCGGGCTGGCCGCGGATCACGCCGCGGTCGAGGCCTATGCCGGCGAGATTTCGGAT
CTCGACGGGAGCGAGGGCGCCACCCGCCGCCATCGCGCGTGGCGTCTCGGGATCGGCGCCGACGTGCTCGAATCCGCGCA
GCGGCGCCGGGAAATCGGCAATTTTCTCGCGTCTCTGTCCACAGCCCGCGGCGTGGAATGA

Upstream 100 bases:

>100_bases
GGCGACCCGTCTCCGCGACGGCGCCGGGCAGATCGGGCAGGGCCTTTTTTCGCATCCGCAGGCCCTCTCGCCCGGATATC
TTCGGAGCCGCCCCACCCCC

Downstream 100 bases:

>100_bases
ACCGAGCGCGACCGGGTGGCACGTTGACCCGCCCGGTCCCGCATCTAGCTTCGCTTTGACGGCCTTCTTTTTCAGGCCGC
GCGGGAGACGCGTTTCCAAT

Product: glutamine amidotransferase class-I

Products: AMP; L-Glutamate; GMP; H+; Diphosphate [C]

Alternate protein names: Glutamine Amidotransferase; Class I Glutamine Amidotransferase Family Protein; Glutamine Amidotransferase Class I; Glutamine Amidotransferase Class-I Family; Glutamine Amidotransferase Protein; Amino Transferase; GMP Synthase; Class I Glutamine Amidotransferase; Glutamine-Hydrolyzing GMP Synthase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTNAMLRLLIADGNDRDGRAKREAAVGQTTSQAFASVVADLAPEVACTLVNPADAEAAIGSDLAGFNGMVLTGSTLRLAD
DGPAVRRQLDLMRAALEAGLPVFGSCWGMQVAAAIAGGDVGENPRGPEYGFARRLTATGDGAAHPLLAGRAPAWDAPAIH
LDAVVGAPSGARVLAANAMLDVQAIEIRYGRGLFWGTQYHPETDLDELAAMLRLSADAVVSAGLAADHAAVEAYAGEISD
LDGSEGATRRHRAWRLGIGADVLESAQRRREIGNFLASLSTARGVE

Sequences:

>Translated_286_residues
MTNAMLRLLIADGNDRDGRAKREAAVGQTTSQAFASVVADLAPEVACTLVNPADAEAAIGSDLAGFNGMVLTGSTLRLAD
DGPAVRRQLDLMRAALEAGLPVFGSCWGMQVAAAIAGGDVGENPRGPEYGFARRLTATGDGAAHPLLAGRAPAWDAPAIH
LDAVVGAPSGARVLAANAMLDVQAIEIRYGRGLFWGTQYHPETDLDELAAMLRLSADAVVSAGLAADHAAVEAYAGEISD
LDGSEGATRRHRAWRLGIGADVLESAQRRREIGNFLASLSTARGVE
>Mature_285_residues
TNAMLRLLIADGNDRDGRAKREAAVGQTTSQAFASVVADLAPEVACTLVNPADAEAAIGSDLAGFNGMVLTGSTLRLADD
GPAVRRQLDLMRAALEAGLPVFGSCWGMQVAAAIAGGDVGENPRGPEYGFARRLTATGDGAAHPLLAGRAPAWDAPAIHL
DAVVGAPSGARVLAANAMLDVQAIEIRYGRGLFWGTQYHPETDLDELAAMLRLSADAVVSAGLAADHAAVEAYAGEISDL
DGSEGATRRHRAWRLGIGADVLESAQRRREIGNFLASLSTARGVE

Specific function: Catalyzes The Synthesis Of Gmp From Xmp. [C]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.5.2 [C]

Molecular weight: Translated: 29623; Mature: 29491

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAMLRLLIADGNDRDGRAKREAAVGQTTSQAFASVVADLAPEVACTLVNPADAEAAIG
CCCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHEEEECCCCCCHHHHC
SDLAGFNGMVLTGSTLRLADDGPAVRRQLDLMRAALEAGLPVFGSCWGMQVAAAIAGGDV
CCCCCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GENPRGPEYGFARRLTATGDGAAHPLLAGRAPAWDAPAIHLDAVVGAPSGARVLAANAML
CCCCCCCCCCHHEEEEECCCCCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEECCEE
DVQAIEIRYGRGLFWGTQYHPETDLDELAAMLRLSADAVVSAGLAADHAAVEAYAGEISD
EEEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LDGSEGATRRHRAWRLGIGADVLESAQRRREIGNFLASLSTARGVE
CCCCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNAMLRLLIADGNDRDGRAKREAAVGQTTSQAFASVVADLAPEVACTLVNPADAEAAIG
CCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHEEEECCCCCCHHHHC
SDLAGFNGMVLTGSTLRLADDGPAVRRQLDLMRAALEAGLPVFGSCWGMQVAAAIAGGDV
CCCCCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
GENPRGPEYGFARRLTATGDGAAHPLLAGRAPAWDAPAIHLDAVVGAPSGARVLAANAML
CCCCCCCCCCHHEEEEECCCCCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEECCEE
DVQAIEIRYGRGLFWGTQYHPETDLDELAAMLRLSADAVVSAGLAADHAAVEAYAGEISD
EEEEEEEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
LDGSEGATRRHRAWRLGIGADVLESAQRRREIGNFLASLSTARGVE
CCCCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1 {NH4+}} 0.42 {6-thioXMP}} 0.53 {ATP}} 2 {1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine} 0.058 {XMP}} 0.029 {XMP}} 0.35 {8-azaXMP}} [C]

Substrates: ATP; L-Glutamine; H2O; Xanthosine 5'-phosphate [C]

Specific reaction: ATP + L-Glutamine + H2O + Xanthosine 5'-phosphate --> AMP + L-Glutamate + GMP + (2) H+ + Diphosphate [C]

General reaction: Amination [C]

Inhibitor: 1, N6-Ethenoadenosine; 1-Methyl adenosine 5'-phosphate 5'-phosphate; 2', 3'-Dihydroadenosine; 2'-Deoxyadenosine; 2, 6-Diaminopurine ribonucleoside; 2-Amino-6-methyl thiopurine ribonucleoside; 2-Fluoroadenosine; 3'-Deoxyadenosine; 5'-Azido-5'-deoxyadenosin

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA