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The map label for this gene is gppA [H]

Identifier: 218531673

GI number: 218531673

Start: 3952898

End: 3954025

Strand: Reverse

Name: gppA [H]

Synonym: Mchl_3742

Alternate gene names: 218531673

Gene position: 3954025-3952898 (Counterclockwise)

Preceding gene: 218531674

Following gene: 218531672

Centisome position: 68.43

GC content: 71.28

Gene sequence:

>1128_bases
ATGAGGGATGAGAGCGCCGCCGCCGTGTCGGCCCGCCCCACCGCCGACCCGCAGACAGCGCGGGAGGGATCCCGCACGGT
CACGGGCGGACGCCCGATCGAAAGCTTCCCTCCCCGCTACGAAACCGGTCGTCACGGCCGCCGCGACGCCTATGCCGCGC
TCGATCTCGGCACCAACAATTGCCGCCTGCTGGTCGCCGAGCCGACGCCCAACGGCTTCCGGGTGATCGACGCGTTCTCC
CGCATCGTCCGGCTCGGCGAGGGGTTGGGCAATTCCAATCGCCTCACCGAGGCGGCAATCGAGCGCACGGTGGAGGCCCT
GCGCATCTGCCGCGGCAAGATGAAATCCCGCGCGGTGGCCCGCTCCAAGGTGATCGCGACCGAGGCCTGCCGGCTTGCCG
TCAACGGCGCCGAGTTCGTGGCGCGGGTGCGCGCCGAGGTCGGGCTCGACCTCGAGATCGTCGACCGGCAGACCGAAGCC
TATCTCGCCGTGACCGGCTGCGCCGCGCTGGCCGACCCGCGGGCGGAATCGGTCGTGATTTTCGATATCGGCGGCGGCTC
CACCGAGATCGCATGGCTCGACGGCGCGGCGGCCAACCCTTCGACCGACCCGACCTTGCGCATCCGCGCCTGGGATTCGC
TCCCCGTCGGTGTGGTGACGCTGGCCGAGCGCCATGGCGGCACCGAGGTCACCCGGCGGACCTTCGAGGGCATGGTCGAG
GAGGTCGGCGACCTCATCTCCCCCTTCGCAATCCGCGCTGCGGCGGCTGCCACCGCACCCTATTTCCACCTGCTCGGCAC
CTCGGGCACCGTGACCACGCTCGCGGCCATGCATCTGCGGCTCGCCCGCTACGAGCGGCGCCGGGTCGATGGCCTCTGGA
TGAGCGACGACGAGGTCGGCGATGCGATCGAGGATCTGCTCGACACCCGCCTCGAACAGCGTGCCGACAACCCCTGTATC
GGCCGCGACCGGGCCGACCTCGTGCTGGCCGGCTGCGCCATCCTGGAGGCGATCCGCCGGGTGTTCCCGTCCGAGCGCCT
GCGCATCGCCGACCGGGGCCTGCGCGAGGGCCTGCTGATGAACATGATGCGCGAGGACGGCGTCTGGCGCCGCGGGCGGT
ATCGCTGA

Upstream 100 bases:

>100_bases
CCATCCAGCCTTTGCAGTTCCTGAATAACGCCTGTAGCCTTGGTGCCACGTCGGCCCGGCGTCTTGCCGGGCTGCATCGC
CAGGAAGTTCGGTCGCGTCG

Downstream 100 bases:

>100_bases
GAAAGCCGGGCCGGCCCTCGTCTCATCGCCCGCGGCGACCGGCTCCCCGGACGGAACGTCTTCACGGACCCGCCGCGCCG
CGATAGGGACCATCCTGCGG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MRDESAAAVSARPTADPQTAREGSRTVTGGRPIESFPPRYETGRHGRRDAYAALDLGTNNCRLLVAEPTPNGFRVIDAFS
RIVRLGEGLGNSNRLTEAAIERTVEALRICRGKMKSRAVARSKVIATEACRLAVNGAEFVARVRAEVGLDLEIVDRQTEA
YLAVTGCAALADPRAESVVIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGTEVTRRTFEGMVE
EVGDLISPFAIRAAAAATAPYFHLLGTSGTVTTLAAMHLRLARYERRRVDGLWMSDDEVGDAIEDLLDTRLEQRADNPCI
GRDRADLVLAGCAILEAIRRVFPSERLRIADRGLREGLLMNMMREDGVWRRGRYR

Sequences:

>Translated_375_residues
MRDESAAAVSARPTADPQTAREGSRTVTGGRPIESFPPRYETGRHGRRDAYAALDLGTNNCRLLVAEPTPNGFRVIDAFS
RIVRLGEGLGNSNRLTEAAIERTVEALRICRGKMKSRAVARSKVIATEACRLAVNGAEFVARVRAEVGLDLEIVDRQTEA
YLAVTGCAALADPRAESVVIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGTEVTRRTFEGMVE
EVGDLISPFAIRAAAAATAPYFHLLGTSGTVTTLAAMHLRLARYERRRVDGLWMSDDEVGDAIEDLLDTRLEQRADNPCI
GRDRADLVLAGCAILEAIRRVFPSERLRIADRGLREGLLMNMMREDGVWRRGRYR
>Mature_375_residues
MRDESAAAVSARPTADPQTAREGSRTVTGGRPIESFPPRYETGRHGRRDAYAALDLGTNNCRLLVAEPTPNGFRVIDAFS
RIVRLGEGLGNSNRLTEAAIERTVEALRICRGKMKSRAVARSKVIATEACRLAVNGAEFVARVRAEVGLDLEIVDRQTEA
YLAVTGCAALADPRAESVVIFDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGTEVTRRTFEGMVE
EVGDLISPFAIRAAAAATAPYFHLLGTSGTVTTLAAMHLRLARYERRRVDGLWMSDDEVGDAIEDLLDTRLEQRADNPCI
GRDRADLVLAGCAILEAIRRVFPSERLRIADRGLREGLLMNMMREDGVWRRGRYR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=335, Percent_Identity=25.3731343283582, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI48994966, Length=330, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 40941; Mature: 40941

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDESAAAVSARPTADPQTAREGSRTVTGGRPIESFPPRYETGRHGRRDAYAALDLGTNN
CCCCCCCEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
CRLLVAEPTPNGFRVIDAFSRIVRLGEGLGNSNRLTEAAIERTVEALRICRGKMKSRAVA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKVIATEACRLAVNGAEFVARVRAEVGLDLEIVDRQTEAYLAVTGCAALADPRAESVVI
HHHHHHHHHHHHEECHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHHHCCCCCCEEEE
FDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGTEVTRRTFEGMVE
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEHHHCCCHHHHHHHHHHHHH
EVGDLISPFAIRAAAAATAPYFHLLGTSGTVTTLAAMHLRLARYERRRVDGLWMSDDEVG
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
DAIEDLLDTRLEQRADNPCIGRDRADLVLAGCAILEAIRRVFPSERLRIADRGLREGLLM
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NMMREDGVWRRGRYR
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MRDESAAAVSARPTADPQTAREGSRTVTGGRPIESFPPRYETGRHGRRDAYAALDLGTNN
CCCCCCCEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
CRLLVAEPTPNGFRVIDAFSRIVRLGEGLGNSNRLTEAAIERTVEALRICRGKMKSRAVA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKVIATEACRLAVNGAEFVARVRAEVGLDLEIVDRQTEAYLAVTGCAALADPRAESVVI
HHHHHHHHHHHHEECHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHHHCCCCCCEEEE
FDIGGGSTEIAWLDGAAANPSTDPTLRIRAWDSLPVGVVTLAERHGGTEVTRRTFEGMVE
EEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCEEEHHHCCCHHHHHHHHHHHHH
EVGDLISPFAIRAAAAATAPYFHLLGTSGTVTTLAAMHLRLARYERRRVDGLWMSDDEVG
HHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
DAIEDLLDTRLEQRADNPCIGRDRADLVLAGCAILEAIRRVFPSERLRIADRGLREGLLM
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
NMMREDGVWRRGRYR
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA