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The map label for this gene is bacC [H]

Identifier: 218531666

GI number: 218531666

Start: 3944768

End: 3946285

Strand: Reverse

Name: bacC [H]

Synonym: Mchl_3735

Alternate gene names: 218531666

Gene position: 3946285-3944768 (Counterclockwise)

Preceding gene: 218531667

Following gene: 218531665

Centisome position: 68.3

GC content: 72.27

Gene sequence:

>1518_bases
ATGGCCCCGACGCTGCTGCACCACCTGCTCGAAGGAGCCGGCGCGGACGATTCCCCCGCGATTGTCGAGGGGGGCGAGAC
CCTCACCTATGGCGGCCTCCGGGCCCGCGTCGCCGCTTTGGCGGAGCGCTTGGCGCGTCTCGGCCTGCGGCCCGGCGACC
GGGTCGCGATCCTGCTGCCGAAATCGATCCGCGAATGCGTCGCGATTTTTGCTGCCAGCGCGGCGGGTGGCGTGTTCGTG
CCGATCCACCCGTCCTTGCGCCCGCGTCAGGTCCACCACATCGTCGCCGATAGCGGCGCGCGCGTGCTGCTGACCGATGC
CGCCCACGCGGCTGGGCTGGAGGGCGCGCTGGACGACCTTTCGGACCTACGCATCCTCGATGGGGAGACGGGTGACGATG
GCGCGGCCCTCATCCCCGGCGAGCCGGCGCCGGAGGGGCTGGCGGCGATCCTCTACACCTCGGGCTCGACCGGCCTGCCC
AAGGGCGTGATGCTCTCCCACGCCAACCTGATCGCCGGCACCCGCATCGTGCGGACCTATCTCGGCATCAACCCCGCGGA
CCGCCTCCTCTCGGTGCTGCCGTTCTCGTTCGATTACGGCCTCAACCAGCTCCTCACCACCGTCGAGCAGGGCGCGCGCA
TCGTGCTGCTGACGCCCCGGCTCGGCGACGACGTGGTGCGGGCGCTGGAGGCGCACCGCATCACGGTGCTGGCGGGCGTG
CCGACGCTTTGGACGCTGCTGACACGGGCCGCGCCGCATCTGGCCAAGGCGGACCTTTCGGCCCTGCGGGCGATCACCAA
TTCCGGCGGCAGCCTCGCCGTGCCGACGATCGAGCGCCTGCGCACGCGGCTGCCGCATACGGCCGTCGTGCTGATGTACG
GCCTGACGGAAGCCTTCCGTTCGACCTACCTGCCGCCGGGGGAGATCGACCGGCGGCCGGACTCGATCGGCCGCGCCATC
CCCGAGACCGAGATCTTCGCCGTCACCCTCGAAGGGCGCCGGGCCCGGCCCGGTGAGCCCGGCATCCTGCATCACCGCGG
CCCGACCGTCTCGATGGGCTACTGGAAGCGGCCCGAGGACACCGCCCGCGTGCTGGTGCCCGACCCGTTCCCGCCGCCCG
GTTCCGCGCCGGGCCTCGTCTGCCGCTCCGGCGACCTCGTGGTGGAGGATGCCGACGGCTTCTTCCGGTTCATCGGCCGC
GAGGACACGATGATCAAGACGCAAGGGTTTCGCGTGAGCCCGACCGAGGTCGAGGCGGCGTTGATGGAGACGGGCGCCTT
CCGCGCCGCCGCTGTGATCGGTCTGCCCGACCCGAGCCTCGGCCAGCGCATCCACGCCGTCACCGTCCCCGTCGAGGGCG
CGCCGGGCACGGCGGATGTGCTGCAGCGCCTCCGCGCGGCGCTGGCGCCCCATCTCGTGCCCCGCACCATCGAGGCGGTG
GCCGCGCTGCCGACCACGCCCAATGGCAAGGTCGATTACAAGCGCCTCACCGCCGAGCGCGCGGCGGTGGAAATCTAG

Upstream 100 bases:

>100_bases
GAGGACAGCTTCGACCTCGCGAACTTCGCCAGCGTCGACACGCTGGCCCATTTCATCGACGACCGGCGTTCCGACGTCTG
ATCCGCGCCTGACCCGTCCC

Downstream 100 bases:

>100_bases
GACCGATGGCTGACGCTCCCGACCTCGCCGCCGCGCTGATCGCCGAGCACTTCTCGCGCGATGCGAGCGGCGTGCTGCGG
GTTGGCGGCCTGCCGCTGAC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: BA3; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; ATP-dependent D-phenylalanine adenylase; D-PheA; D-phenylalanine activase; ATP-dependent histidine adenylase; HisA; Histidine activase; ATP-dependent D-aspartate adenylase; D-AspA; D-aspartate activase; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; Aspartate racemase; Phenylalanine racemase [ATP hydrolyzing] [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MAPTLLHHLLEGAGADDSPAIVEGGETLTYGGLRARVAALAERLARLGLRPGDRVAILLPKSIRECVAIFAASAAGGVFV
PIHPSLRPRQVHHIVADSGARVLLTDAAHAAGLEGALDDLSDLRILDGETGDDGAALIPGEPAPEGLAAILYTSGSTGLP
KGVMLSHANLIAGTRIVRTYLGINPADRLLSVLPFSFDYGLNQLLTTVEQGARIVLLTPRLGDDVVRALEAHRITVLAGV
PTLWTLLTRAAPHLAKADLSALRAITNSGGSLAVPTIERLRTRLPHTAVVLMYGLTEAFRSTYLPPGEIDRRPDSIGRAI
PETEIFAVTLEGRRARPGEPGILHHRGPTVSMGYWKRPEDTARVLVPDPFPPPGSAPGLVCRSGDLVVEDADGFFRFIGR
EDTMIKTQGFRVSPTEVEAALMETGAFRAAAVIGLPDPSLGQRIHAVTVPVEGAPGTADVLQRLRAALAPHLVPRTIEAV
AALPTTPNGKVDYKRLTAERAAVEI

Sequences:

>Translated_505_residues
MAPTLLHHLLEGAGADDSPAIVEGGETLTYGGLRARVAALAERLARLGLRPGDRVAILLPKSIRECVAIFAASAAGGVFV
PIHPSLRPRQVHHIVADSGARVLLTDAAHAAGLEGALDDLSDLRILDGETGDDGAALIPGEPAPEGLAAILYTSGSTGLP
KGVMLSHANLIAGTRIVRTYLGINPADRLLSVLPFSFDYGLNQLLTTVEQGARIVLLTPRLGDDVVRALEAHRITVLAGV
PTLWTLLTRAAPHLAKADLSALRAITNSGGSLAVPTIERLRTRLPHTAVVLMYGLTEAFRSTYLPPGEIDRRPDSIGRAI
PETEIFAVTLEGRRARPGEPGILHHRGPTVSMGYWKRPEDTARVLVPDPFPPPGSAPGLVCRSGDLVVEDADGFFRFIGR
EDTMIKTQGFRVSPTEVEAALMETGAFRAAAVIGLPDPSLGQRIHAVTVPVEGAPGTADVLQRLRAALAPHLVPRTIEAV
AALPTTPNGKVDYKRLTAERAAVEI
>Mature_504_residues
APTLLHHLLEGAGADDSPAIVEGGETLTYGGLRARVAALAERLARLGLRPGDRVAILLPKSIRECVAIFAASAAGGVFVP
IHPSLRPRQVHHIVADSGARVLLTDAAHAAGLEGALDDLSDLRILDGETGDDGAALIPGEPAPEGLAAILYTSGSTGLPK
GVMLSHANLIAGTRIVRTYLGINPADRLLSVLPFSFDYGLNQLLTTVEQGARIVLLTPRLGDDVVRALEAHRITVLAGVP
TLWTLLTRAAPHLAKADLSALRAITNSGGSLAVPTIERLRTRLPHTAVVLMYGLTEAFRSTYLPPGEIDRRPDSIGRAIP
ETEIFAVTLEGRRARPGEPGILHHRGPTVSMGYWKRPEDTARVLVPDPFPPPGSAPGLVCRSGDLVVEDADGFFRFIGRE
DTMIKTQGFRVSPTEVEAALMETGAFRAAAVIGLPDPSLGQRIHAVTVPVEGAPGTADVLQRLRAALAPHLVPRTIEAVA
ALPTTPNGKVDYKRLTAERAAVEI

Specific function: Induces peptide synthesis, activates and incorporates five amino acids, forms a thiazoline ring between the first two amino acids and incoporates a D-glutamine in the fourth position [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 5 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=527, Percent_Identity=28.6527514231499, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI187761343, Length=527, Percent_Identity=28.6527514231499, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI156151445, Length=517, Percent_Identity=23.7911025145068, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI58082049, Length=474, Percent_Identity=25.9493670886076, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI157311624, Length=472, Percent_Identity=25.635593220339, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI157311622, Length=472, Percent_Identity=25.635593220339, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI38505220, Length=484, Percent_Identity=26.4462809917355, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=22.3938223938224, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI122937307, Length=475, Percent_Identity=24.8421052631579, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI115511026, Length=507, Percent_Identity=24.4575936883629, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1788107, Length=529, Percent_Identity=28.9224952741021, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI145693145, Length=509, Percent_Identity=28.0943025540275, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786801, Length=512, Percent_Identity=26.7578125, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786810, Length=522, Percent_Identity=25.095785440613, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI221142682, Length=498, Percent_Identity=26.1044176706827, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789201, Length=365, Percent_Identity=29.041095890411, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=489, Percent_Identity=27.19836400818, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17557194, Length=521, Percent_Identity=24.7600767754319, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=498, Percent_Identity=25.7028112449799, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531443, Length=495, Percent_Identity=24.8484848484848, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17538037, Length=522, Percent_Identity=24.3295019157088, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17560308, Length=533, Percent_Identity=23.4521575984991, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=519, Percent_Identity=24.6628131021195, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994690, Length=519, Percent_Identity=24.6628131021195, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71994694, Length=519, Percent_Identity=24.6628131021195, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=371, Percent_Identity=25.8760107816712, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71996755, Length=504, Percent_Identity=22.6190476190476, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71985884, Length=350, Percent_Identity=25.4285714285714, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=27.1276595744681, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323182, Length=546, Percent_Identity=24.9084249084249, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319264, Length=532, Percent_Identity=24.4360902255639, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859661, Length=500, Percent_Identity=29, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24581924, Length=556, Percent_Identity=27.3381294964029, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355181, Length=488, Percent_Identity=26.2295081967213, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922652, Length=502, Percent_Identity=24.5019920318725, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358303, Length=468, Percent_Identity=23.5042735042735, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281365686, Length=325, Percent_Identity=27.0769230769231, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356441, Length=493, Percent_Identity=23.7322515212982, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=23.4714003944773, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648260, Length=348, Percent_Identity=26.4367816091954, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356947, Length=504, Percent_Identity=23.8095238095238, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648253, Length=466, Percent_Identity=23.8197424892704, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648255, Length=466, Percent_Identity=23.8197424892704, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653035, Length=488, Percent_Identity=21.9262295081967, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130357, Length=357, Percent_Identity=25.2100840336134, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: =5.1.1.13; =5.1.1.11 [H]

Molecular weight: Translated: 53379; Mature: 53248

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPTLLHHLLEGAGADDSPAIVEGGETLTYGGLRARVAALAERLARLGLRPGDRVAILLP
CCHHHHHHHHHCCCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECC
KSIRECVAIFAASAAGGVFVPIHPSLRPRQVHHIVADSGARVLLTDAAHAAGLEGALDDL
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHEEEECCCCEEEEECCHHHCCCCHHHHHH
SDLRILDGETGDDGAALIPGEPAPEGLAAILYTSGSTGLPKGVMLSHANLIAGTRIVRTY
HCCEEECCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCCHHEECCHHHHHHHHHHHH
LGINPADRLLSVLPFSFDYGLNQLLTTVEQGARIVLLTPRLGDDVVRALEAHRITVLAGV
HCCCHHHHHHHHCCCHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCEEEEEECC
PTLWTLLTRAAPHLAKADLSALRAITNSGGSLAVPTIERLRTRLPHTAVVLMYGLTEAFR
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHH
STYLPPGEIDRRPDSIGRAIPETEIFAVTLEGRRARPGEPGILHHRGPTVSMGYWKRPED
HCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCCCEEECCCCCCCCC
TARVLVPDPFPPPGSAPGLVCRSGDLVVEDADGFFRFIGREDTMIKTQGFRVSPTEVEAA
CCEEEECCCCCCCCCCCCEEEECCCEEEECCCCHHHHHCCCCCEEEECCEECCHHHHHHH
LMETGAFRAAAVIGLPDPSLGQRIHAVTVPVEGAPGTADVLQRLRAALAPHLVPRTIEAV
HHHCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
AALPTTPNGKVDYKRLTAERAAVEI
HHCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
APTLLHHLLEGAGADDSPAIVEGGETLTYGGLRARVAALAERLARLGLRPGDRVAILLP
CHHHHHHHHHCCCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECC
KSIRECVAIFAASAAGGVFVPIHPSLRPRQVHHIVADSGARVLLTDAAHAAGLEGALDDL
HHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHEEEECCCCEEEEECCHHHCCCCHHHHHH
SDLRILDGETGDDGAALIPGEPAPEGLAAILYTSGSTGLPKGVMLSHANLIAGTRIVRTY
HCCEEECCCCCCCCCEECCCCCCCCCEEEEEEECCCCCCCCCHHEECCHHHHHHHHHHHH
LGINPADRLLSVLPFSFDYGLNQLLTTVEQGARIVLLTPRLGDDVVRALEAHRITVLAGV
HCCCHHHHHHHHCCCHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCEEEEEECC
PTLWTLLTRAAPHLAKADLSALRAITNSGGSLAVPTIERLRTRLPHTAVVLMYGLTEAFR
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHH
STYLPPGEIDRRPDSIGRAIPETEIFAVTLEGRRARPGEPGILHHRGPTVSMGYWKRPED
HCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCCCEEECCCCCCCCC
TARVLVPDPFPPPGSAPGLVCRSGDLVVEDADGFFRFIGREDTMIKTQGFRVSPTEVEAA
CCEEEECCCCCCCCCCCCEEEECCCEEEECCCCHHHHHCCCCCEEEECCEECCHHHHHHH
LMETGAFRAAAVIGLPDPSLGQRIHAVTVPVEGAPGTADVLQRLRAALAPHLVPRTIEAV
HHHCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
AALPTTPNGKVDYKRLTAERAAVEI
HHCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9427658 [H]