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The map label for this gene is lysA [H]

Identifier: 218531665

GI number: 218531665

Start: 3943476

End: 3944762

Strand: Reverse

Name: lysA [H]

Synonym: Mchl_3734

Alternate gene names: 218531665

Gene position: 3944762-3943476 (Counterclockwise)

Preceding gene: 218531666

Following gene: 218531661

Centisome position: 68.27

GC content: 71.56

Gene sequence:

>1287_bases
ATGGCTGACGCTCCCGACCTCGCCGCCGCGCTGATCGCCGAGCACTTCTCGCGCGATGCGAGCGGCGTGCTGCGGGTTGG
CGGCCTGCCGCTGACCGAGCTCGCAAGGGATTTCGGCACGCCGCTCTTCGTCTACGACGCCGATACGATGCGCCGGATCT
ACCGAGCGCTGTGCGCGGCACTCGCCGACTTCGCGGAGGTGGATTTTTCGGTCAAGGCGAACCCCAACCCGGCGGTGATC
CGCGTCTTCTCTCAGGAGGGCGCGGGGGCCGAGATCGCCTCCGGCGCCGAGTTCGACGCCGCGATCAGGGCGGGCGTTCC
ACCGGACAAGATCCTGTTCGCCGGCCCAGGCAAGGGTGCGGCCGATCTCGACCGGGTGATCGGTGACGGCATCGGCGAAA
TCCATCTCGAAAACCGCGAGGAGATTGTTCGCGTCGCGGCGGCGGCCGAGCGTCACGGCGTGCGCGTGCGGGTGGCGCTG
CGGATCAATCCCGGTGCGACCGCGCAAGGCGGGGCGATGCGGATGGGCGGCAAGCCTTCGCCGTTCGGCTTCGACGAGGA
AGACATTGAGGCCGCCATCGACACCGTGGAGGCCGCACCGCGCTTGCGCCTCGTCGGGCTTCACCTGTTCGCAGGCACGC
AAGGGCTGAAGGCGGACACTCTCCTCGGCCAGTGGCGCTACGGGCTCGGGCTGGCGGCGCGGATCGCGAACCGGACCGGG
CGGCCGCTGGAGACGATCGATCTCGGCGGCGGCCTCGGCATCCCGTACTTTTCCGGCGACACCGCCCTCGATCTCGGCGC
GATCCGGGCCGGGCTGCCCGACCTGATCGCCACCCTGCGGGCGGACCCGCTGATGGCGAGCGCCCGCGTGGTGCTGGAGC
CCGGGCGCTACCTCACCGGGCCGGCGGGTGTCTACGTGGCGCGGGTGCTGGCGCTGAAGGAATCGCGCGGCAGCCGCTTT
GTCATCACCGATGGCGGCATGCACCATCATCTCGCCGCCAGCGGCAATCTCGGCCAGATCGTCAAGCGCGACTTTCCCCT
CGCCGCGGTGACCGATCTGGGCGGTGAGCGCGCGGCGACCGCAGTCGTCGGCCCGCTCTGCACGCCGCTGGACATGCTGG
CCCGCGCCGCCCCCCTGCCGCCGCTGGCCGAGGGCGATCTCGTCGCGGTGCTGCAATCGGGCGCCTACGGGCTCACCGCG
AGCCCGATGGGCTTCCTGAGCCACCCGACCCCGGCCGAAGTGCTGGTGGACGGGGGCGAGGCCAGGGAGATCCGGGCACG
CGGCTGA

Upstream 100 bases:

>100_bases
GCACCATCGAGGCGGTGGCCGCGCTGCCGACCACGCCCAATGGCAAGGTCGATTACAAGCGCCTCACCGCCGAGCGCGCG
GCGGTGGAAATCTAGGACCG

Downstream 100 bases:

>100_bases
TCCTGGCGCGTTCCGAAACCGCGCCGCGGTTGCGGAAGCCCCCATCGCGCTCGCGTGACGGGGGCCTCGGATGCCGTTCG
GGATGTGGTGGCGCGGCTTG

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MADAPDLAAALIAEHFSRDASGVLRVGGLPLTELARDFGTPLFVYDADTMRRIYRALCAALADFAEVDFSVKANPNPAVI
RVFSQEGAGAEIASGAEFDAAIRAGVPPDKILFAGPGKGAADLDRVIGDGIGEIHLENREEIVRVAAAAERHGVRVRVAL
RINPGATAQGGAMRMGGKPSPFGFDEEDIEAAIDTVEAAPRLRLVGLHLFAGTQGLKADTLLGQWRYGLGLAARIANRTG
RPLETIDLGGGLGIPYFSGDTALDLGAIRAGLPDLIATLRADPLMASARVVLEPGRYLTGPAGVYVARVLALKESRGSRF
VITDGGMHHHLAASGNLGQIVKRDFPLAAVTDLGGERAATAVVGPLCTPLDMLARAAPLPPLAEGDLVAVLQSGAYGLTA
SPMGFLSHPTPAEVLVDGGEAREIRARG

Sequences:

>Translated_428_residues
MADAPDLAAALIAEHFSRDASGVLRVGGLPLTELARDFGTPLFVYDADTMRRIYRALCAALADFAEVDFSVKANPNPAVI
RVFSQEGAGAEIASGAEFDAAIRAGVPPDKILFAGPGKGAADLDRVIGDGIGEIHLENREEIVRVAAAAERHGVRVRVAL
RINPGATAQGGAMRMGGKPSPFGFDEEDIEAAIDTVEAAPRLRLVGLHLFAGTQGLKADTLLGQWRYGLGLAARIANRTG
RPLETIDLGGGLGIPYFSGDTALDLGAIRAGLPDLIATLRADPLMASARVVLEPGRYLTGPAGVYVARVLALKESRGSRF
VITDGGMHHHLAASGNLGQIVKRDFPLAAVTDLGGERAATAVVGPLCTPLDMLARAAPLPPLAEGDLVAVLQSGAYGLTA
SPMGFLSHPTPAEVLVDGGEAREIRARG
>Mature_427_residues
ADAPDLAAALIAEHFSRDASGVLRVGGLPLTELARDFGTPLFVYDADTMRRIYRALCAALADFAEVDFSVKANPNPAVIR
VFSQEGAGAEIASGAEFDAAIRAGVPPDKILFAGPGKGAADLDRVIGDGIGEIHLENREEIVRVAAAAERHGVRVRVALR
INPGATAQGGAMRMGGKPSPFGFDEEDIEAAIDTVEAAPRLRLVGLHLFAGTQGLKADTLLGQWRYGLGLAARIANRTGR
PLETIDLGGGLGIPYFSGDTALDLGAIRAGLPDLIATLRADPLMASARVVLEPGRYLTGPAGVYVARVLALKESRGSRFV
ITDGGMHHHLAASGNLGQIVKRDFPLAAVTDLGGERAATAVVGPLCTPLDMLARAAPLPPLAEGDLVAVLQSGAYGLTAS
PMGFLSHPTPAEVLVDGGEAREIRARG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=420, Percent_Identity=29.7619047619048, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=22.6519337016575, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=387, Percent_Identity=21.7054263565891, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24586472, Length=361, Percent_Identity=22.9916897506925, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44472; Mature: 44341

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAPDLAAALIAEHFSRDASGVLRVGGLPLTELARDFGTPLFVYDADTMRRIYRALCAA
CCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHH
LADFAEVDFSVKANPNPAVIRVFSQEGAGAEIASGAEFDAAIRAGVPPDKILFAGPGKGA
HHHHHHCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCH
ADLDRVIGDGIGEIHLENREEIVRVAAAAERHGVRVRVALRINPGATAQGGAMRMGGKPS
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCEEECCCCCC
PFGFDEEDIEAAIDTVEAAPRLRLVGLHLFAGTQGLKADTLLGQWRYGLGLAARIANRTG
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPLETIDLGGGLGIPYFSGDTALDLGAIRAGLPDLIATLRADPLMASARVVLEPGRYLTG
CCCEEEECCCCCCCCEECCCCCEEHHHHHCCHHHHHHHHCCCCCHHCCEEEECCCCEECC
PAGVYVARVLALKESRGSRFVITDGGMHHHLAASGNLGQIVKRDFPLAAVTDLGGERAAT
CHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHCCCCEEEECCCCCCHHHH
AVVGPLCTPLDMLARAAPLPPLAEGDLVAVLQSGAYGLTASPMGFLSHPTPAEVLVDGGE
HHHCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHEEECCCC
AREIRARG
CCEECCCC
>Mature Secondary Structure 
ADAPDLAAALIAEHFSRDASGVLRVGGLPLTELARDFGTPLFVYDADTMRRIYRALCAA
CCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHH
LADFAEVDFSVKANPNPAVIRVFSQEGAGAEIASGAEFDAAIRAGVPPDKILFAGPGKGA
HHHHHHCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCH
ADLDRVIGDGIGEIHLENREEIVRVAAAAERHGVRVRVALRINPGATAQGGAMRMGGKPS
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCEEECCCCCC
PFGFDEEDIEAAIDTVEAAPRLRLVGLHLFAGTQGLKADTLLGQWRYGLGLAARIANRTG
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPLETIDLGGGLGIPYFSGDTALDLGAIRAGLPDLIATLRADPLMASARVVLEPGRYLTG
CCCEEEECCCCCCCCEECCCCCEEHHHHHCCHHHHHHHHCCCCCHHCCEEEECCCCEECC
PAGVYVARVLALKESRGSRFVITDGGMHHHLAASGNLGQIVKRDFPLAAVTDLGGERAAT
CHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHCCCCEEEECCCCCCHHHH
AVVGPLCTPLDMLARAAPLPPLAEGDLVAVLQSGAYGLTASPMGFLSHPTPAEVLVDGGE
HHHCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHEEECCCC
AREIRARG
CCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA