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The map label for this gene is nhaA1 [H]

Identifier: 218531542

GI number: 218531542

Start: 3802265

End: 3803506

Strand: Reverse

Name: nhaA1 [H]

Synonym: Mchl_3610

Alternate gene names: 218531542

Gene position: 3803506-3802265 (Counterclockwise)

Preceding gene: 218531543

Following gene: 218531541

Centisome position: 65.83

GC content: 70.77

Gene sequence:

>1242_bases
ATGAAGCCGCCGCCCCCCTCCGTCCGTGCGCTCCCGCGCCCTCTGCAACGCTCGTACTCGGCAACGCGCCGCTTTCTCAC
GAACGAAGCGGCCGGCGGCATCGTGCTCATGGCCGCCGCGGGCGCCGCGCTCGTGGTCGCCAATTCGCCCATAGCGCAGG
CCTATCACGACCTCCTGCACATCCATCTCGGGCCCTTGAGCCTGATGCACTGGATCAACGACGGCCTGATGGTCGTGTTC
TTCCTGCTGGTCGGCCTCGAGATCAAGCGAGAGGGACTGGACGGGCGCCTGCGCACCTGGCCCGACCGGGTGCTGCCGGG
CCTTGCCGCCGCGGCGGGCATGGCCGTGCCGGCCCTGGTCTACCTCGCTTTCAATGCCGGGCAGTCCACGGCTCGGGGCT
GGGCGATCCCCGCCGCCACCGACATCGCCTTCGCGCTGGGCGTCCTCGCGCTGCTGGGCTCGCGCGTGCCCGTTTCACTC
AAGATCTTCCTGTCGGCGGTGGCCATCGTCGACGATCTCGGCGCCGTGGTCATCATCGCGCTGTTCTATACGGGGCAGCT
CGATACCACGATGCTGGCGGCCTCGGCCGGGATGCTGGCCGTGCTGTTTGCCCTCAACCGCCTCGGTGTGCGCGCGCTCC
TGCCCTATCTCCTCGCGGGCCTCGTCCTCTGGGTGTTCGTCCTGCGCTCCGGCGTTCACGCCACGGTGGCCGGCGTGCTG
CTCGCCCTGTTCGTGCCGATCCGCCCGAGCCCGGGCCGGCCGGAGGACACGACCTCGCCCCTGCACCGTCTGGAGCACGC
CCTGACGCCCTGGGTCTCGTTCCTGATCGTGCCGATCTTCGGCTTCGCCAATGCCGGGGTGACGCTCCTCGGCTTGCCGG
CGCAGGCGCTGATCGAGCCCGTGACCCTCGGCGTCGCGCTCGGCCTGTTCATCGGCAAGCAGGTCGGCATCTTCGCGAGC
GTGCGGATCGCCGCCGCCCTTGGCCTCGTTTCCCGCCCGGCGGGGGCGACCTGGGTTCAAGTCTACGGCGTCGCGCTCCT
CTGCGGCATCGGCTTCACCATGAGCCTGTTCATCGGCGCGCTCGCCTTCACGGATGGCCTGCACGAGACCGAGACCAAGC
TCGGCGTCCTCGGCGGCTCGCTGCTCTCGGCGCTGTTCGGTGCCGTGCTGCTCGCCCAGGCCACCGCGCGGGAGGCGAGC
CCGCGCCGGGACCTCAGAGCCGGGCCCGACCGCTTGCCTTGA

Upstream 100 bases:

>100_bases
TCCGGGCGGCGCTGGCGAAACCCTCCTGATTTTCCGAGGTGCCCGATTTTCCAAGCCAACGGGTTGCGGTGCCGGCCCGG
GGCGGGCAACGGGTCACGGC

Downstream 100 bases:

>100_bases
CCTCCGGCCTCGGCCTACTCAGGCCGGAAGCGTCGCGGTGGTAGGTGGTCCGTCCTCCGGCCCGTCATCCCGCGCGAGGG
CGAACATGCTGCGAACCGTT

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKPPPPSVRALPRPLQRSYSATRRFLTNEAAGGIVLMAAAGAALVVANSPIAQAYHDLLHIHLGPLSLMHWINDGLMVVF
FLLVGLEIKREGLDGRLRTWPDRVLPGLAAAAGMAVPALVYLAFNAGQSTARGWAIPAATDIAFALGVLALLGSRVPVSL
KIFLSAVAIVDDLGAVVIIALFYTGQLDTTMLAASAGMLAVLFALNRLGVRALLPYLLAGLVLWVFVLRSGVHATVAGVL
LALFVPIRPSPGRPEDTTSPLHRLEHALTPWVSFLIVPIFGFANAGVTLLGLPAQALIEPVTLGVALGLFIGKQVGIFAS
VRIAAALGLVSRPAGATWVQVYGVALLCGIGFTMSLFIGALAFTDGLHETETKLGVLGGSLLSALFGAVLLAQATAREAS
PRRDLRAGPDRLP

Sequences:

>Translated_413_residues
MKPPPPSVRALPRPLQRSYSATRRFLTNEAAGGIVLMAAAGAALVVANSPIAQAYHDLLHIHLGPLSLMHWINDGLMVVF
FLLVGLEIKREGLDGRLRTWPDRVLPGLAAAAGMAVPALVYLAFNAGQSTARGWAIPAATDIAFALGVLALLGSRVPVSL
KIFLSAVAIVDDLGAVVIIALFYTGQLDTTMLAASAGMLAVLFALNRLGVRALLPYLLAGLVLWVFVLRSGVHATVAGVL
LALFVPIRPSPGRPEDTTSPLHRLEHALTPWVSFLIVPIFGFANAGVTLLGLPAQALIEPVTLGVALGLFIGKQVGIFAS
VRIAAALGLVSRPAGATWVQVYGVALLCGIGFTMSLFIGALAFTDGLHETETKLGVLGGSLLSALFGAVLLAQATAREAS
PRRDLRAGPDRLP
>Mature_413_residues
MKPPPPSVRALPRPLQRSYSATRRFLTNEAAGGIVLMAAAGAALVVANSPIAQAYHDLLHIHLGPLSLMHWINDGLMVVF
FLLVGLEIKREGLDGRLRTWPDRVLPGLAAAAGMAVPALVYLAFNAGQSTARGWAIPAATDIAFALGVLALLGSRVPVSL
KIFLSAVAIVDDLGAVVIIALFYTGQLDTTMLAASAGMLAVLFALNRLGVRALLPYLLAGLVLWVFVLRSGVHATVAGVL
LALFVPIRPSPGRPEDTTSPLHRLEHALTPWVSFLIVPIFGFANAGVTLLGLPAQALIEPVTLGVALGLFIGKQVGIFAS
VRIAAALGLVSRPAGATWVQVYGVALLCGIGFTMSLFIGALAFTDGLHETETKLGVLGGSLLSALFGAVLLAQATAREAS
PRRDLRAGPDRLP

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=377, Percent_Identity=51.4588859416446, Blast_Score=304, Evalue=6e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 43170; Mature: 43170

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPPPSVRALPRPLQRSYSATRRFLTNEAAGGIVLMAAAGAALVVANSPIAQAYHDLLH
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHHH
IHLGPLSLMHWINDGLMVVFFLLVGLEIKREGLDGRLRTWPDRVLPGLAAAAGMAVPALV
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YLAFNAGQSTARGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSAVAIVDDLGAVVIIA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFYTGQLDTTMLAASAGMLAVLFALNRLGVRALLPYLLAGLVLWVFVLRSGVHATVAGVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LALFVPIRPSPGRPEDTTSPLHRLEHALTPWVSFLIVPIFGFANAGVTLLGLPAQALIEP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
VTLGVALGLFIGKQVGIFASVRIAAALGLVSRPAGATWVQVYGVALLCGIGFTMSLFIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAFTDGLHETETKLGVLGGSLLSALFGAVLLAQATAREASPRRDLRAGPDRLP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MKPPPPSVRALPRPLQRSYSATRRFLTNEAAGGIVLMAAAGAALVVANSPIAQAYHDLLH
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHHHHHHHH
IHLGPLSLMHWINDGLMVVFFLLVGLEIKREGLDGRLRTWPDRVLPGLAAAAGMAVPALV
HHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YLAFNAGQSTARGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSAVAIVDDLGAVVIIA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFYTGQLDTTMLAASAGMLAVLFALNRLGVRALLPYLLAGLVLWVFVLRSGVHATVAGVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LALFVPIRPSPGRPEDTTSPLHRLEHALTPWVSFLIVPIFGFANAGVTLLGLPAQALIEP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
VTLGVALGLFIGKQVGIFASVRIAAALGLVSRPAGATWVQVYGVALLCGIGFTMSLFIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAFTDGLHETETKLGVLGGSLLSALFGAVLLAQATAREASPRRDLRAGPDRLP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA