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The map label for this gene is mltB [H]

Identifier: 218531528

GI number: 218531528

Start: 3790883

End: 3792064

Strand: Reverse

Name: mltB [H]

Synonym: Mchl_3596

Alternate gene names: 218531528

Gene position: 3792064-3790883 (Counterclockwise)

Preceding gene: 218531529

Following gene: 218531527

Centisome position: 65.63

GC content: 73.52

Gene sequence:

>1182_bases
GTGAGAGCACCCCGCGCCGCCGTCATCCTCGCACTCGCGCTGCTGGCGGGGCCGGCCCAGGCGCAGGATGGCGACTTCTC
CGGCTTCGTCGCGTCGCTGCGCCCCGACGCCACGGCCCGCGGCATCTCGCCGAAGACCTTCGACGCGGCGTTTGCCGGCG
TGCAGGGGCCGGACCCGGATGTCGTCGCCCGCACCCGCCGCCAGAGCGAGTTCAGCCGGCCGGTCTGGGACTACCTCGTC
GGCGCGGTCTCGGGCGCCCGCATCACCCGGGGGCAGGCGCAGGGCAAGCGGCTCGCGGCCTCCCTCGCCGCCATCGAGGC
GAAGACCGGTGTGCCGCGCTCGGTCGTGCTGGCCTTCTGGGGGGTCGAGTCGGATTTCGGCGCCAGCGCCGGCTCCCTGC
CGACGGTCCGCGCGCTGGCGAGTCTGGCTTACGCCCGGCACCGCGGAACCCTGTTTCGCGACGAGTTGCTGGCCGCCCTC
CAGATCCTCGAGAACGGCGATATCGAGCCGGCGCGGATGGTCGGCTCCTGGGCCGGGGCCATGGGGCAGGTGCAGTTCCT
GCCCTCGGTCTACCTGCGGGAGGCGGTCGATTTCGACGGCGACGGGCGGCGCGACATCTGGCGCTCCGAGGCCGATGCGC
TGGCCTCCATCGCGCATTACCTGCAATCGCTCGGTTGGAAGCCAGGCCTGTCCTGGGGCTACGAGGTCAGCCTGCCGAAG
GATTTCGACCTGACCCGCTACCGCGGCCCGCTCGCAGACTTCGCCACCCGCGGGGTGCGCCGCACCGACGGCAAACCCTT
GCCGACGGGCGGCGAGGCCAGCCTGTTCCTGCCGGGCGGGCTCGGGAGCCCGGTCTTCCTCATCACCGACAATTTCGAGG
TGATCCGCGGCTACAACACCAGCGATTCCTACGCGCTGGCGGTCGGCCACCTCGCCGACCGGCTGGCCGGCGGCCCGGCG
CTCGCCGCGCCCTGGCCCAACGGCGCCGCCCGCCTCGACGGCCTGGGCCTCAAGCGTCTCCAGGCAGGGCTCGCCGCCCA
GGGGCTCTATGCCGGCGAACAGGATGGACGCGCCGGCCCGAAGCTGCGCGAGGCGGTGCGGCAGTACCAGATCCGCGAGG
GCCTGCCCGCCGACGGCTACGCCCGGCCCGCGCTTCTGGAGCGCTTGGAGGGACGGCCATAG

Upstream 100 bases:

>100_bases
TCCGCAACGAACTCGGCTGGACCCCGAAGTACGACGACCTCGACGTCATCGTCGCCCAGGCGCTTGCCTGGGAGGATACC
CTGGCCAAGCGGAACCGGCG

Downstream 100 bases:

>100_bases
AGCGCATTCCGACGAAGTGGTCACCGGTTCGTCGAAAGAATGCGCGTCAAAACAAAGACTGAGAGCCGTCTCCGGCCTGA
TGCCATCAGGTCGGAGACGG

Product: lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRAPRAAVILALALLAGPAQAQDGDFSGFVASLRPDATARGISPKTFDAAFAGVQGPDPDVVARTRRQSEFSRPVWDYLV
GAVSGARITRGQAQGKRLAASLAAIEAKTGVPRSVVLAFWGVESDFGASAGSLPTVRALASLAYARHRGTLFRDELLAAL
QILENGDIEPARMVGSWAGAMGQVQFLPSVYLREAVDFDGDGRRDIWRSEADALASIAHYLQSLGWKPGLSWGYEVSLPK
DFDLTRYRGPLADFATRGVRRTDGKPLPTGGEASLFLPGGLGSPVFLITDNFEVIRGYNTSDSYALAVGHLADRLAGGPA
LAAPWPNGAARLDGLGLKRLQAGLAAQGLYAGEQDGRAGPKLREAVRQYQIREGLPADGYARPALLERLEGRP

Sequences:

>Translated_393_residues
MRAPRAAVILALALLAGPAQAQDGDFSGFVASLRPDATARGISPKTFDAAFAGVQGPDPDVVARTRRQSEFSRPVWDYLV
GAVSGARITRGQAQGKRLAASLAAIEAKTGVPRSVVLAFWGVESDFGASAGSLPTVRALASLAYARHRGTLFRDELLAAL
QILENGDIEPARMVGSWAGAMGQVQFLPSVYLREAVDFDGDGRRDIWRSEADALASIAHYLQSLGWKPGLSWGYEVSLPK
DFDLTRYRGPLADFATRGVRRTDGKPLPTGGEASLFLPGGLGSPVFLITDNFEVIRGYNTSDSYALAVGHLADRLAGGPA
LAAPWPNGAARLDGLGLKRLQAGLAAQGLYAGEQDGRAGPKLREAVRQYQIREGLPADGYARPALLERLEGRP
>Mature_393_residues
MRAPRAAVILALALLAGPAQAQDGDFSGFVASLRPDATARGISPKTFDAAFAGVQGPDPDVVARTRRQSEFSRPVWDYLV
GAVSGARITRGQAQGKRLAASLAAIEAKTGVPRSVVLAFWGVESDFGASAGSLPTVRALASLAYARHRGTLFRDELLAAL
QILENGDIEPARMVGSWAGAMGQVQFLPSVYLREAVDFDGDGRRDIWRSEADALASIAHYLQSLGWKPGLSWGYEVSLPK
DFDLTRYRGPLADFATRGVRRTDGKPLPTGGEASLFLPGGLGSPVFLITDNFEVIRGYNTSDSYALAVGHLADRLAGGPA
LAAPWPNGAARLDGLGLKRLQAGLAAQGLYAGEQDGRAGPKLREAVRQYQIREGLPADGYARPALLERLEGRP

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=214, Percent_Identity=35.0467289719626, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41748; Mature: 41748

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPRAAVILALALLAGPAQAQDGDFSGFVASLRPDATARGISPKTFDAAFAGVQGPDPD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHH
VVARTRRQSEFSRPVWDYLVGAVSGARITRGQAQGKRLAASLAAIEAKTGVPRSVVLAFW
HHHHHHHHHHHCCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHEEE
GVESDFGASAGSLPTVRALASLAYARHRGTLFRDELLAALQILENGDIEPARMVGSWAGA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MGQVQFLPSVYLREAVDFDGDGRRDIWRSEADALASIAHYLQSLGWKPGLSWGYEVSLPK
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
DFDLTRYRGPLADFATRGVRRTDGKPLPTGGEASLFLPGGLGSPVFLITDNFEVIRGYNT
CCCHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCEEEEECCCC
SDSYALAVGHLADRLAGGPALAAPWPNGAARLDGLGLKRLQAGLAAQGLYAGEQDGRAGP
CCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCH
KLREAVRQYQIREGLPADGYARPALLERLEGRP
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MRAPRAAVILALALLAGPAQAQDGDFSGFVASLRPDATARGISPKTFDAAFAGVQGPDPD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHH
VVARTRRQSEFSRPVWDYLVGAVSGARITRGQAQGKRLAASLAAIEAKTGVPRSVVLAFW
HHHHHHHHHHHCCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHHHHEEE
GVESDFGASAGSLPTVRALASLAYARHRGTLFRDELLAALQILENGDIEPARMVGSWAGA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MGQVQFLPSVYLREAVDFDGDGRRDIWRSEADALASIAHYLQSLGWKPGLSWGYEVSLPK
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCC
DFDLTRYRGPLADFATRGVRRTDGKPLPTGGEASLFLPGGLGSPVFLITDNFEVIRGYNT
CCCHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCEEEEECCCC
SDSYALAVGHLADRLAGGPALAAPWPNGAARLDGLGLKRLQAGLAAQGLYAGEQDGRAGP
CCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCH
KLREAVRQYQIREGLPADGYARPALLERLEGRP
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]