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The map label for this gene is thrC [H]

Identifier: 218531510

GI number: 218531510

Start: 3768055

End: 3769467

Strand: Reverse

Name: thrC [H]

Synonym: Mchl_3578

Alternate gene names: 218531510

Gene position: 3769467-3768055 (Counterclockwise)

Preceding gene: 218531511

Following gene: 218531509

Centisome position: 65.24

GC content: 68.58

Gene sequence:

>1413_bases
TTGCTGCACGTCTCGACCCGCGGCGCCGCTGCGCCCTTGAGCTTTTCCGATGCGCTGCTCGCCGGCCTTGCCCGCGACGG
CGGTCTCTACGTGCCCGAGAGCTGGCCGCAGATTAGCCGTGCGGAGATCGCGGGCTTTGCCGGCATGCGCTACGCCGAGG
TTGCCAAGCGCGTGCTGCGTCCGCTCATCGACGGCGAGATTCCGGACGACGCGCTCGACGAGATGATCGAGGCGGCCTAC
GCCACCTTCCGCCATCCGGCGATCTGCCCGCTCACCCAGATCGACGACAACCTGTTCCTGATGGAGCTGTTTCACGGGCC
GACGCTCGCGTTCAAGGACGTGGCGATGCAGCTCCTCGGGCGGCTGATGGATTACGTGCTGCGCCAGAAGGGCGGCCGCG
CCACCATCGTCGGCGCCACCTCGGGCGATACGGGCAGTGCCGCGGTCGAGGCCTTCAAGGGGCTCGATCAGGTCGACGTG
TTCATCCTGTTTCCGCACGGCCGCGTCTCGGAGGTGCAGCGCCGGCAGATGACCACGGTCAACGCGCCGAACGTCCACGC
GCTCGCCATCGACGGCAATTTCGACGATTGCCAGAACATCGTGAAGGCGATGTTCCAGCACGGCGACTTCGCCGACAGGG
TGAAGCTCTCGGGCGTCAACTCGATCAATTGGGCCCGCGTCGCCGCGCAGACCGTCTACTACTTCACGAGTGCGGTGGCT
CTGGGCGCCCCGCACCGGAAGGTGTCGTTCGCGGTGCCGACCGGCAATTTCGGCGACATCCTCGCCGGCTGGGTCGCCAA
GCGGATGGGCCTGCCGATCGAGCGGCTGATGATCGGCACCAATGCCAACGACATCCTGGCCCGCACCCTGGAGCACGGGG
CCTACGAGCCCCGCGGCGTGCAGCCGACGACCTCGCCCTCGATGGACATCCAGATCTCCTCGAACTTCGAGCGGCTGCTG
TTCGAGGCGTTGGGCCGCGATGCCTCCGCGCTCGGCCGCCTGATGGCGGGTCTGAAGCAGTCGGGCGGGTTCTCGCTGAG
CCCCGAGGTGCTGGGCACCGTGCGCGACGAGTTCGATGCGACCGCCGTGCGCGAGCCCGACGTCGTGGAAGAGATCGCGG
GCACCTTCCGCAAGACCGGCCTCGTGCTCGATCCGCACAGCGCCATCGGCGTGCGTGCCGGTCGCAGGCTGCTGGAGAAG
GATCCGGCCACCCCGGTCGTGGCGCTGGCCACCGCGCACCCCGCCAAATTCCCGAATGCGGTCTCGCAGGCGACCGGCGG
CGGGCGCCCGGTTCTGCCGCCCCACCTCGCCGAACTGATGACACGGCCCGAGACGGTGGCGAACCTCGCCAACGATCAGG
CCGCGATCGAGCGCTACATCACGGAACACGCCCGCATCACCCGGGGCAACTGA

Upstream 100 bases:

>100_bases
GGCGAGAAGGTTTGACGCCGCAGATGTGAGAAACCGATCCGGCCCCGCTTCGACACGGCCGAATCGATCGTGTAGAGGGA
GCGCCTTCCCGGAGGCATCT

Downstream 100 bases:

>100_bases
CGGACCGACAGCGTGACATCCAACCCAACCCCCTCATCCTGAGGTGCCGCGAAGCGGCCTCGAAGGGCCCTCCAGATCCC
GCGCGATCTCTGGACGATCC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLHVSTRGAAAPLSFSDALLAGLARDGGLYVPESWPQISRAEIAGFAGMRYAEVAKRVLRPLIDGEIPDDALDEMIEAAY
ATFRHPAICPLTQIDDNLFLMELFHGPTLAFKDVAMQLLGRLMDYVLRQKGGRATIVGATSGDTGSAAVEAFKGLDQVDV
FILFPHGRVSEVQRRQMTTVNAPNVHALAIDGNFDDCQNIVKAMFQHGDFADRVKLSGVNSINWARVAAQTVYYFTSAVA
LGAPHRKVSFAVPTGNFGDILAGWVAKRMGLPIERLMIGTNANDILARTLEHGAYEPRGVQPTTSPSMDIQISSNFERLL
FEALGRDASALGRLMAGLKQSGGFSLSPEVLGTVRDEFDATAVREPDVVEEIAGTFRKTGLVLDPHSAIGVRAGRRLLEK
DPATPVVALATAHPAKFPNAVSQATGGGRPVLPPHLAELMTRPETVANLANDQAAIERYITEHARITRGN

Sequences:

>Translated_470_residues
MLHVSTRGAAAPLSFSDALLAGLARDGGLYVPESWPQISRAEIAGFAGMRYAEVAKRVLRPLIDGEIPDDALDEMIEAAY
ATFRHPAICPLTQIDDNLFLMELFHGPTLAFKDVAMQLLGRLMDYVLRQKGGRATIVGATSGDTGSAAVEAFKGLDQVDV
FILFPHGRVSEVQRRQMTTVNAPNVHALAIDGNFDDCQNIVKAMFQHGDFADRVKLSGVNSINWARVAAQTVYYFTSAVA
LGAPHRKVSFAVPTGNFGDILAGWVAKRMGLPIERLMIGTNANDILARTLEHGAYEPRGVQPTTSPSMDIQISSNFERLL
FEALGRDASALGRLMAGLKQSGGFSLSPEVLGTVRDEFDATAVREPDVVEEIAGTFRKTGLVLDPHSAIGVRAGRRLLEK
DPATPVVALATAHPAKFPNAVSQATGGGRPVLPPHLAELMTRPETVANLANDQAAIERYITEHARITRGN
>Mature_470_residues
MLHVSTRGAAAPLSFSDALLAGLARDGGLYVPESWPQISRAEIAGFAGMRYAEVAKRVLRPLIDGEIPDDALDEMIEAAY
ATFRHPAICPLTQIDDNLFLMELFHGPTLAFKDVAMQLLGRLMDYVLRQKGGRATIVGATSGDTGSAAVEAFKGLDQVDV
FILFPHGRVSEVQRRQMTTVNAPNVHALAIDGNFDDCQNIVKAMFQHGDFADRVKLSGVNSINWARVAAQTVYYFTSAVA
LGAPHRKVSFAVPTGNFGDILAGWVAKRMGLPIERLMIGTNANDILARTLEHGAYEPRGVQPTTSPSMDIQISSNFERLL
FEALGRDASALGRLMAGLKQSGGFSLSPEVLGTVRDEFDATAVREPDVVEEIAGTFRKTGLVLDPHSAIGVRAGRRLLEK
DPATPVVALATAHPAKFPNAVSQATGGGRPVLPPHLAELMTRPETVANLANDQAAIERYITEHARITRGN

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=447, Percent_Identity=34.0044742729307, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI153792148, Length=434, Percent_Identity=34.7926267281106, Blast_Score=249, Evalue=5e-66,
Organism=Escherichia coli, GI1786185, Length=452, Percent_Identity=34.7345132743363, Blast_Score=239, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6319901, Length=460, Percent_Identity=43.695652173913, Blast_Score=358, Evalue=1e-100,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50611; Mature: 50611

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHVSTRGAAAPLSFSDALLAGLARDGGLYVPESWPQISRAEIAGFAGMRYAEVAKRVLR
CEEECCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
PLIDGEIPDDALDEMIEAAYATFRHPAICPLTQIDDNLFLMELFHGPTLAFKDVAMQLLG
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEHHCCCCHHHHHHHHHHHH
RLMDYVLRQKGGRATIVGATSGDTGSAAVEAFKGLDQVDVFILFPHGRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCC
NAPNVHALAIDGNFDDCQNIVKAMFQHGDFADRVKLSGVNSINWARVAAQTVYYFTSAVA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRKVSFAVPTGNFGDILAGWVAKRMGLPIERLMIGTNANDILARTLEHGAYEPRGV
HCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHCCCCCCCC
QPTTSPSMDIQISSNFERLLFEALGRDASALGRLMAGLKQSGGFSLSPEVLGTVRDEFDA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCH
TAVREPDVVEEIAGTFRKTGLVLDPHSAIGVRAGRRLLEKDPATPVVALATAHPAKFPNA
HCCCCCHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHH
VSQATGGGRPVLPPHLAELMTRPETVANLANDQAAIERYITEHARITRGN
HHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLHVSTRGAAAPLSFSDALLAGLARDGGLYVPESWPQISRAEIAGFAGMRYAEVAKRVLR
CEEECCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
PLIDGEIPDDALDEMIEAAYATFRHPAICPLTQIDDNLFLMELFHGPTLAFKDVAMQLLG
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEHHCCCCHHHHHHHHHHHH
RLMDYVLRQKGGRATIVGATSGDTGSAAVEAFKGLDQVDVFILFPHGRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCC
NAPNVHALAIDGNFDDCQNIVKAMFQHGDFADRVKLSGVNSINWARVAAQTVYYFTSAVA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRKVSFAVPTGNFGDILAGWVAKRMGLPIERLMIGTNANDILARTLEHGAYEPRGV
HCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHEECCCCHHHHHHHHHHCCCCCCCC
QPTTSPSMDIQISSNFERLLFEALGRDASALGRLMAGLKQSGGFSLSPEVLGTVRDEFDA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCH
TAVREPDVVEEIAGTFRKTGLVLDPHSAIGVRAGRRLLEKDPATPVVALATAHPAKFPNA
HCCCCCHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHH
VSQATGGGRPVLPPHLAELMTRPETVANLANDQAAIERYITEHARITRGN
HHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]