Click here to switch to the map view.

The map label for this gene is pyrE

Identifier: 218531450

GI number: 218531450

Start: 3703538

End: 3704128

Strand: Reverse

Name: pyrE

Synonym: Mchl_3518

Alternate gene names: 218531450

Gene position: 3704128-3703538 (Counterclockwise)

Preceding gene: 218531451

Following gene: 218531449

Centisome position: 64.11

GC content: 69.2

Gene sequence:

>591_bases
ATGACGCCGGAAGAAGTTCTCGAAGAGTTCCGTTCCGCAGGGGCCCTGCTGCAGGGACACTTCATCCTCAGTTCCGGCCT
GCGCTCGTCCACCTTCCTGCAGAAGATGACGATCTTCTCCGATCCCGCGCGCACCGAGCGGCTGTGCCGGGCGCTGGCCG
AGGTTATCACGGCCCGCTTCGGCCGGATCGACATCGTGGTCTCTCCGGCCATCGGCGGCATCATCCCCGGCTACGAGACC
GCCCGCCATCTCGGCGCCAAGGCGATCTTCGTCGAGCGCGACCCCGGCGGTCCCTTCACTCTGCGCCGCGGCTTCTCGAT
CCCCGCCGGCACCCGTGCCGTCATCGTCGAGGACATCGTGACGACGGGTCTCTCGGCCCGGGAATGCCTCGCCTCGCTGA
AGGATGAGGCGGGCGAGGTGGTGGGTGCCGCTTGCCTGATCGACCGTTCGGGCGGACGGGGCGCGATCGGCCTGCCGCTC
CTGTCCCTGGTCACGCTCGACATCCCGACTTACGCGCCGGACGCTCTGCCCGCTGAGCTGGCCGCCATCCCCCCGGTCAA
GCCGGGCAGCCGGGCCTTGTCGAAGCCCTGA

Upstream 100 bases:

>100_bases
CGCGGTTGATGCGCTCCCGGTTGATGCGTTTGGCCTTCGGCTTGCGCCTCGCTTGCGCCGCTGCAAGAAGCACGGAACAC
AGTTTGGCGAGCAGGTGATC

Downstream 100 bases:

>100_bases
CCCGGCGCGGGACGGGCGCTGGTTCGGCTGCGAAGTTTCCGCGCCGGCAGCCCATGTCAATTCCCTCGCCGCGGCAACTT
CAGGTATGTAAATACCGCGG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTPEEVLEEFRSAGALLQGHFILSSGLRSSTFLQKMTIFSDPARTERLCRALAEVITARFGRIDIVVSPAIGGIIPGYET
ARHLGAKAIFVERDPGGPFTLRRGFSIPAGTRAVIVEDIVTTGLSARECLASLKDEAGEVVGAACLIDRSGGRGAIGLPL
LSLVTLDIPTYAPDALPAELAAIPPVKPGSRALSKP

Sequences:

>Translated_196_residues
MTPEEVLEEFRSAGALLQGHFILSSGLRSSTFLQKMTIFSDPARTERLCRALAEVITARFGRIDIVVSPAIGGIIPGYET
ARHLGAKAIFVERDPGGPFTLRRGFSIPAGTRAVIVEDIVTTGLSARECLASLKDEAGEVVGAACLIDRSGGRGAIGLPL
LSLVTLDIPTYAPDALPAELAAIPPVKPGSRALSKP
>Mature_195_residues
TPEEVLEEFRSAGALLQGHFILSSGLRSSTFLQKMTIFSDPARTERLCRALAEVITARFGRIDIVVSPAIGGIIPGYETA
RHLGAKAIFVERDPGGPFTLRRGFSIPAGTRAVIVEDIVTTGLSARECLASLKDEAGEVVGAACLIDRSGGRGAIGLPLL
SLVTLDIPTYAPDALPAELAAIPPVKPGSRALSKP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_METC4 (B7KVD0)

Other databases:

- EMBL:   CP001298
- RefSeq:   YP_002422266.1
- ProteinModelPortal:   B7KVD0
- SMR:   B7KVD0
- GeneID:   7114276
- GenomeReviews:   CP001298_GR
- KEGG:   mch:Mchl_3518
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   CLSK2331572
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20589; Mature: 20458

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 121-121 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEEVLEEFRSAGALLQGHFILSSGLRSSTFLQKMTIFSDPARTERLCRALAEVITARF
CCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRIDIVVSPAIGGIIPGYETARHLGAKAIFVERDPGGPFTLRRGFSIPAGTRAVIVEDIV
CCEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHH
TTGLSARECLASLKDEAGEVVGAACLIDRSGGRGAIGLPLLSLVTLDIPTYAPDALPAEL
HCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
AAIPPVKPGSRALSKP
HCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPEEVLEEFRSAGALLQGHFILSSGLRSSTFLQKMTIFSDPARTERLCRALAEVITARF
CHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GRIDIVVSPAIGGIIPGYETARHLGAKAIFVERDPGGPFTLRRGFSIPAGTRAVIVEDIV
CCEEEEECCCCCCCCCCHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHH
TTGLSARECLASLKDEAGEVVGAACLIDRSGGRGAIGLPLLSLVTLDIPTYAPDALPAEL
HCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHH
AAIPPVKPGSRALSKP
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA