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The map label for this gene is icd [H]

Identifier: 218531395

GI number: 218531395

Start: 3649608

End: 3650822

Strand: Reverse

Name: icd [H]

Synonym: Mchl_3463

Alternate gene names: 218531395

Gene position: 3650822-3649608 (Counterclockwise)

Preceding gene: 218531396

Following gene: 218531390

Centisome position: 63.19

GC content: 63.54

Gene sequence:

>1215_bases
ATGGCGAAGATCAAGGTGGCCAATCCGGTCGTCGAGCTCGACGGCGACGAGATGACCCGGATCATCTGGGCGGAGATCAA
GAACAAGCTCATCCACCCCTACCTCGATCTCGATCTCGACTATTACGATCTCGGTGTCGAGCACCGCGACGCGACGAACG
ACCAGGTGACGATCGATGCGGCCGAGGCGATCAAGCGCCACGGCGTCGGCGTGAAATGCGCCACGATCACGCCGGACGAG
GCCCGCGTCGAGGAATTCAAGCTCAAGGAGATGTGGCGGTCGCCCAACGGCACGATCCGCAACATCCTCGGCGGCGTCAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTGCCGCGCCTCGTGCCCGGCTGGACCCAGCCCTTCGTGATCGGCCGCCACG
CCTACGGCGACCAGTACCGCGCCACCGACTTCAAGGTGCCGGGCAAGGGCCGCCTCACCATCAAGTTCGAGGGTGACGAC
GGCACCGTCATCGAGAAGGAGGTGTTCAAGTTCCCGGACGCCGGCGTCGCGATGTCGATGTACAACCTCGACCAGTCGAT
CATCGACTTCGCCCGCGCCTCGTTCAACTACGGCCTCGCCCGCAAATACCCGGTCTATCTCTCGACCAAGAACACCATCC
TCAAGACCTATGACGGCCGCTTCAAGGATCTGTTCCAGAAGGTGTTCGACGAGGAGTTCAAGTCGAAGTTCCTGTCGCTC
GGCCTAACCTATGAGCACCGCCTGATCGACGACATGGTGGCTTCCTGCCTCAAGTGGTCGGGTGGCTATGTCTGGGCCTG
TAAGAACTACGACGGCGACGTGCAGTCGGACACCGCCGCGCAGGGCTTCGGCTCGCTCGGCCTGATGACTTCGGTGCTGA
TGACGCCGGACGGACAGACCGTGGAGGCCGAGGCTGCCCACGGCACCGTCACGCGCCACTACCGCGAGCACCAGAAGGGC
AAGGCGACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTGTCGCACCGGGCCAAGCTCGACGGCAA
CGCCGATCTCGCGAAGTTCGCCGCGACCCTGGAGAAGGTCTGCGTCGACACGGTCGAGGCCGGCCACATGACGAAGGATC
TCGCCCTCCTCGTCGGCCCGGACCAGAAGTGGCTCACCACCAACGGCTTCCTCGACAAGGTCGATGAGAACCTGAAGACG
GCGATGGCCGTCTGA

Upstream 100 bases:

>100_bases
GCCTTGCTGCGCTGCGTTATAGGGGCGGCGACAGGGTTCCGGAGAGACGCGCGAAGGGCAGCCGGCCGCGCGCGCTGCAC
CGGGCAACTGAGGGACCGAC

Downstream 100 bases:

>100_bases
GGCGCCAGCCTAACGGCCCTCCCCCCGCAAAAAAGGGGGAGGGTCGAGAAACCTCAGCCCGCCTTCTTCGCCGCATTCCG
CTTGCGCGTCTCGGCCGCCT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVTIDAAEAIKRHGVGVKCATITPDE
ARVEEFKLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDD
GTVIEKEVFKFPDAGVAMSMYNLDQSIIDFARASFNYGLARKYPVYLSTKNTILKTYDGRFKDLFQKVFDEEFKSKFLSL
GLTYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KATSTNSIASIFAWTRGLSHRAKLDGNADLAKFAATLEKVCVDTVEAGHMTKDLALLVGPDQKWLTTNGFLDKVDENLKT
AMAV

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVTIDAAEAIKRHGVGVKCATITPDE
ARVEEFKLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDD
GTVIEKEVFKFPDAGVAMSMYNLDQSIIDFARASFNYGLARKYPVYLSTKNTILKTYDGRFKDLFQKVFDEEFKSKFLSL
GLTYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKG
KATSTNSIASIFAWTRGLSHRAKLDGNADLAKFAATLEKVCVDTVEAGHMTKDLALLVGPDQKWLTTNGFLDKVDENLKT
AMAV
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVTIDAAEAIKRHGVGVKCATITPDEA
RVEEFKLKEMWRSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDG
TVIEKEVFKFPDAGVAMSMYNLDQSIIDFARASFNYGLARKYPVYLSTKNTILKTYDGRFKDLFQKVFDEEFKSKFLSLG
LTYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKGK
ATSTNSIASIFAWTRGLSHRAKLDGNADLAKFAATLEKVCVDTVEAGHMTKDLALLVGPDQKWLTTNGFLDKVDENLKTA
MAV

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=66.421568627451, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=66.0975609756098, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=64.3734643734644, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=66.1691542288557, Blast_Score=552, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=63.3663366336634, Blast_Score=532, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=61.1793611793612, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320137, Length=405, Percent_Identity=62.7160493827161, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=63.3251833740831, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=63.3251833740831, Blast_Score=550, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=63.3251833740831, Blast_Score=550, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45140; Mature: 45009

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVTIDA
CCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCEEEEEH
AEAIKRHGVGVKCATITPDEARVEEFKLKEMWRSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDGTVIEKEVFKFPDAGVAMSM
CCCCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCCEEHHHHHCCCCCCCEEHH
YNLDQSIIDFARASFNYGLARKYPVYLSTKNTILKTYDGRFKDLFQKVFDEEFKSKFLSL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
GLTYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYREHQKGKATSTNSIASIFAWTRGLSHRAKLDGNADLAKFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVDTVEAGHMTKDLALLVGPDQKWLTTNGFLDKVDENLKTAMAV
HHHHHHCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVTIDA
CEEEECCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCEEEEEH
AEAIKRHGVGVKCATITPDEARVEEFKLKEMWRSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPFVIGRHAYGDQYRATDFKVPGKGRLTIKFEGDDGTVIEKEVFKFPDAGVAMSM
CCCCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCCEEHHHHHCCCCCCCEEHH
YNLDQSIIDFARASFNYGLARKYPVYLSTKNTILKTYDGRFKDLFQKVFDEEFKSKFLSL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
GLTYEHRLIDDMVASCLKWSGGYVWACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYREHQKGKATSTNSIASIFAWTRGLSHRAKLDGNADLAKFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVDTVEAGHMTKDLALLVGPDQKWLTTNGFLDKVDENLKTAMAV
HHHHHHCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]