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The map label for this gene is guaD [H]

Identifier: 218531388

GI number: 218531388

Start: 3642542

End: 3643003

Strand: Reverse

Name: guaD [H]

Synonym: Mchl_3456

Alternate gene names: 218531388

Gene position: 3643003-3642542 (Counterclockwise)

Preceding gene: 218531389

Following gene: 218531385

Centisome position: 63.05

GC content: 69.48

Gene sequence:

>462_bases
ATGCCGGACCACGAGAGCTATCTGCGCGAGGCGACCGAAATCGCCCTCGCCAACGTCGCCGAGGGTGGCCGACCCTACGG
CGCGGTGATCGTGCGGGATGGGGAGGTGGTCGTGCGGGCGGCCAACCGCATCCACGCGACCAACGATCCGAGCGACCACG
CCGAGATGGTGGCAATCCGCGCGGCGAGCCAGCAGCTTGGCAGGCCCAAGCTCGACGATTGCATCGTCTACGCCAGCGGG
CGACCCTGCCCGATGTGCCATGCGGCGATGCGGCTCGCCGGGGTCAAGCAGGGCTACTTCGCCTTCACCGCCGAGGAGGC
GGAGGCCGAGGGTCTGCTCAGTGCCGAAATCTATGCCGAGCTGTGCCGGCCGCTTGAAGAGCAGCCGATGCAGGTGCGCC
ACCTCCCGCTTGCCGACGAGCCGAGTCCCTACCGCGCCTGGGCGGAGCGGAAAGGGCGCTGA

Upstream 100 bases:

>100_bases
CCGGCTGGAAAGGGAAATGGCTCGCCCGCTTCAAGGCGCTGCTCGCCGAGCGGATGCCCTATTGCCGGGTGCGCTACGCA
TTCTGAGGAGAAGAAAACCG

Downstream 100 bases:

>100_bases
ACGCGGGGTTCAGCCTCACGAAACGCCCGCTGCTTCCGGCGCGGTGGGCGCCTCGTGAGCGACACTCAGTGTGTCCAGGG
CGCCGTGCGGTTGAACTTGA

Product: CMP/dCMP deaminase zinc-binding

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MPDHESYLREATEIALANVAEGGRPYGAVIVRDGEVVVRAANRIHATNDPSDHAEMVAIRAASQQLGRPKLDDCIVYASG
RPCPMCHAAMRLAGVKQGYFAFTAEEAEAEGLLSAEIYAELCRPLEEQPMQVRHLPLADEPSPYRAWAERKGR

Sequences:

>Translated_153_residues
MPDHESYLREATEIALANVAEGGRPYGAVIVRDGEVVVRAANRIHATNDPSDHAEMVAIRAASQQLGRPKLDDCIVYASG
RPCPMCHAAMRLAGVKQGYFAFTAEEAEAEGLLSAEIYAELCRPLEEQPMQVRHLPLADEPSPYRAWAERKGR
>Mature_152_residues
PDHESYLREATEIALANVAEGGRPYGAVIVRDGEVVVRAANRIHATNDPSDHAEMVAIRAASQQLGRPKLDDCIVYASGR
PCPMCHAAMRLAGVKQGYFAFTAEEAEAEGLLSAEIYAELCRPLEEQPMQVRHLPLADEPSPYRAWAERKGR

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554608, Length=148, Percent_Identity=29.7297297297297, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555996, Length=151, Percent_Identity=33.112582781457, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16814; Mature: 16683

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHESYLREATEIALANVAEGGRPYGAVIVRDGEVVVRAANRIHATNDPSDHAEMVAIR
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCEECCCCCCHHHHHHHHH
AASQQLGRPKLDDCIVYASGRPCPMCHAAMRLAGVKQGYFAFTAEEAEAEGLLSAEIYAE
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHH
LCRPLEEQPMQVRHLPLADEPSPYRAWAERKGR
HHCCHHHCCCEEEECCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
PDHESYLREATEIALANVAEGGRPYGAVIVRDGEVVVRAANRIHATNDPSDHAEMVAIR
CCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCEECCCCCCHHHHHHHHH
AASQQLGRPKLDDCIVYASGRPCPMCHAAMRLAGVKQGYFAFTAEEAEAEGLLSAEIYAE
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHH
LCRPLEEQPMQVRHLPLADEPSPYRAWAERKGR
HHCCHHHCCCEEEECCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]