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The map label for this gene is nhaA [H]

Identifier: 218531356

GI number: 218531356

Start: 3610716

End: 3611576

Strand: Reverse

Name: nhaA [H]

Synonym: Mchl_3424

Alternate gene names: 218531356

Gene position: 3611576-3610716 (Counterclockwise)

Preceding gene: 218531357

Following gene: 218531355

Centisome position: 62.51

GC content: 72.59

Gene sequence:

>861_bases
ATGCCGCTGACCATCCCGACCTGGATGCGCCGCCTCCTGCCTCGCCGCTTCCGCGAGACCCCGCCGCGGGTCGCCGTGGT
GCGCCTGAGCGGGGCGATCGGCGCCGTCTCGCCGATCCGGGCGGGCCTTTCCATCGGCACGGTGGCGCCGAGCCTGGAGC
GTGCCTTCACCATGCCGGGCCTGTCGGCGGTGGCGCTTGTCATCAACTCCCCCGGCGGATCGCCGGTGCAATCGCACCTG
ATCTACCGGCGCATCCGGGCGCTGGCGGCGGAGAAGGAGATCAGGGTCTTCGCCTTCGTGGAGGATGCCGCGGCCTCGGG
CGGCTACATGATCGCCTGCGCTGCCGATGAGATCGTCGCCGATCCCGCCTCGCTCGTCGGCTCCATCGGCGTGGTCTCGG
CCGGCTTCGGCTTCGACCGGCTGATCGAGCGCATCGGCATCGAGCGCCGCGTCCACACCCAGGGCGAGGCCAAGGCGATG
CTCGACCCGTTCCGCCCGGAAAACCCGCAGGACATCGCCCGGCTGAAGGAGATCCAGGCCGACGTGCAGGCCCTGTTCTC
CGGCCTCGTACGCGAGCGCCGGCCGACGCTCGACGCCAGCCGCGACCTGTTCACCGGCGCGGTCTGGACCGGGCGGCAGG
CGCTCGATCTCGGCCTCGTCGATGCGCTCGGCGACCTACGCGGCACCCTGCGCGCCCGCTACGGCGAGAAGGTCGATCTG
CGGCTCGTGGCCGAGAATCGTGGCTCCTGGCTCGCCCGCCTGCTGCGCCGCGCCGGCCCCGGCCAGACCACGACCGGCCT
ACCTGATGCGCTGATCGCAGCGGTGGAGGAGCGTGCGGCCTGGGCACGGCTCGGGCTGTAG

Upstream 100 bases:

>100_bases
CCCCATGTTTAGACACGCAGTCTTTCGACGAATCGGTGACCGCTTCGTCGAGATGCGATCTAGGAAGCCGCGCACCCGCG
CGTTCTGAAAAAAGGCCGCC

Downstream 100 bases:

>100_bases
GCTGCGAGCGAAGACTCGCGGTCCTGTTCGCGGCTCGTGATTAGAATCCGCCCGACACAGATTCGAGATCAGGATTGTCA
GCGCAAGAGAACGGCTGTAC

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPLTIPTWMRRLLPRRFRETPPRVAVVRLSGAIGAVSPIRAGLSIGTVAPSLERAFTMPGLSAVALVINSPGGSPVQSHL
IYRRIRALAAEKEIRVFAFVEDAAASGGYMIACAADEIVADPASLVGSIGVVSAGFGFDRLIERIGIERRVHTQGEAKAM
LDPFRPENPQDIARLKEIQADVQALFSGLVRERRPTLDASRDLFTGAVWTGRQALDLGLVDALGDLRGTLRARYGEKVDL
RLVAENRGSWLARLLRRAGPGQTTTGLPDALIAAVEERAAWARLGL

Sequences:

>Translated_286_residues
MPLTIPTWMRRLLPRRFRETPPRVAVVRLSGAIGAVSPIRAGLSIGTVAPSLERAFTMPGLSAVALVINSPGGSPVQSHL
IYRRIRALAAEKEIRVFAFVEDAAASGGYMIACAADEIVADPASLVGSIGVVSAGFGFDRLIERIGIERRVHTQGEAKAM
LDPFRPENPQDIARLKEIQADVQALFSGLVRERRPTLDASRDLFTGAVWTGRQALDLGLVDALGDLRGTLRARYGEKVDL
RLVAENRGSWLARLLRRAGPGQTTTGLPDALIAAVEERAAWARLGL
>Mature_285_residues
PLTIPTWMRRLLPRRFRETPPRVAVVRLSGAIGAVSPIRAGLSIGTVAPSLERAFTMPGLSAVALVINSPGGSPVQSHLI
YRRIRALAAEKEIRVFAFVEDAAASGGYMIACAADEIVADPASLVGSIGVVSAGFGFDRLIERIGIERRVHTQGEAKAML
DPFRPENPQDIARLKEIQADVQALFSGLVRERRPTLDASRDLFTGAVWTGRQALDLGLVDALGDLRGTLRARYGEKVDLR
LVAENRGSWLARLLRRAGPGQTTTGLPDALIAAVEERAAWARLGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=210, Percent_Identity=31.9047619047619, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788064, Length=213, Percent_Identity=30.9859154929577, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 30844; Mature: 30713

Theoretical pI: Translated: 10.97; Mature: 10.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTIPTWMRRLLPRRFRETPPRVAVVRLSGAIGAVSPIRAGLSIGTVAPSLERAFTMPG
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCHHHCCHHHHHHHCCCC
LSAVALVINSPGGSPVQSHLIYRRIRALAAEKEIRVFAFVEDAAASGGYMIACAADEIVA
HHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECHHHHC
DPASLVGSIGVVSAGFGFDRLIERIGIERRVHTQGEAKAMLDPFRPENPQDIARLKEIQA
CHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
DVQALFSGLVRERRPTLDASRDLFTGAVWTGRQALDLGLVDALGDLRGTLRARYGEKVDL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
RLVAENRGSWLARLLRRAGPGQTTTGLPDALIAAVEERAAWARLGL
EEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLTIPTWMRRLLPRRFRETPPRVAVVRLSGAIGAVSPIRAGLSIGTVAPSLERAFTMPG
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCHHHCCHHHHHHHCCCC
LSAVALVINSPGGSPVQSHLIYRRIRALAAEKEIRVFAFVEDAAASGGYMIACAADEIVA
HHEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECHHHHC
DPASLVGSIGVVSAGFGFDRLIERIGIERRVHTQGEAKAMLDPFRPENPQDIARLKEIQA
CHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
DVQALFSGLVRERRPTLDASRDLFTGAVWTGRQALDLGLVDALGDLRGTLRARYGEKVDL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
RLVAENRGSWLARLLRRAGPGQTTTGLPDALIAAVEERAAWARLGL
EEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA