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The map label for this gene is cvrA [H]

Identifier: 218531293

GI number: 218531293

Start: 3540992

End: 3542254

Strand: Reverse

Name: cvrA [H]

Synonym: Mchl_3351

Alternate gene names: 218531293

Gene position: 3542254-3540992 (Counterclockwise)

Preceding gene: 218531295

Following gene: 218531292

Centisome position: 61.31

GC content: 67.62

Gene sequence:

>1263_bases
GTGATCTCCATCTTCGACCTCGTCGCGATGTTGCTGACGCTGTCCGCCCTGTTCGGCTGGATCAACGGGCGCTTCATCCA
CATGCCACACAGCATCGGCATGCTGGTCCTGGGGCTCGTCGCCTCGCTTCTGCTGGTCCTCCTCGACGTCGCCTTCCCGA
ACAAGCACCTCTACGAGGCCCTGACCGGCCCGTTGCGGCAGATTGACTTCACCGACGTGGTGATGAACGGGATGCTGGCC
TTCCTGCTGTTCGCGGGCGCCATGACCCTCGACCTGAGCGCGTTGCGCGACAGGGCTTGGCCCGTTGCCACGCTGGCCCT
CGTCGGGACCGTCATCTCGACGGCCATCGTCGGCAGCGCCTTCTGGGCGGTGGCCCAATGGTCCGGGCATCCGGTCTCGC
TCGCCTGGGCACTTGTCTTCGGCGCCCTGATCAGTCCGACCGACCCGGTCGCGGTGCTCGCCACCCTGAAGAACGTGAAG
GTGCCGCTCTCCTTGGAGATCGAGATGCAGGGGGAGGCGCTGTTCAACGACGGGGTCGGCATTGTCCTGTTCACCGTCCT
CCTCGGCTTCGCGGCCGGCATCGGCGGAGAGGCATCCAGCGCCGGCGGCATCGCACGTCTGCTCCTGCAGGAAGCCGGCG
GCGGCCTGCTTCTGGGCGTCGTCACCGGGTACGTCGCCTATCGCGCCATGCGAGCCATCGACGACTTCCCGGTCGAGGTC
CTGATCACGCTGGCGCTGGTGGCGGGCACCTATGCTCTGGCCCAGAAGCTCCACGCCAGCGGTCCCCTGGCGGTGGTCGC
GGCCGGCCTGCTGGTTGGCGACAGGGCCCCGCGCGATGCCATGAGCGAGCGCACCCAGGGCTACGTCTCGTCCCTTTGGA
CCCTCGTAGACGAGGTCCTGAACTCGGTGCTGTTCCTGCTGATCGGCCTAGAGGTGCTGGTCCTGCGCTTCGAGGCCGGC
TCCTTCGTCCTTGCGGCGGCCGCGGTCCCGATTGTCCTCCTTGCGCGATTGGTGGCGGTCTCCGCTCCCTTGCTGGCCTT
CCGTTGGGGCGGAAACCTGTCGGCGCGAAACGTGCCGTTCCTGACCTGGGCCGGCGTCCGCGGCGGCATCTCGGTCGCGC
TGGCCCTCTCCGTCCCGGAGAGCGACGCGAAGGCTGCGATCCTCGCGGCGACCTACGCCGTGGTGCTGTTCACCATCATT
GTCCAGGGATCGACCCTGGCTATGGTAGCCCGTCGCACCCTGTCTACCCCTGGCTCAGGGTAA

Upstream 100 bases:

>100_bases
CGCGTCCCTATGGTGCACTCCGCAATGGGCGATCCATCCACCAGGAGCCTCTCCTGCGTCGTTGGCGTTGGACCGCGGGC
GGCATTGTCAGGAACGATCC

Downstream 100 bases:

>100_bases
CCCCCGCCGCGCTTCTCAGTCATAACACAGCTTCGGAGGCACGAACGGCATCGCGCCGAGGCGGGAGCCCGAACCGCACT
TCGTCGTGCCCGTATACGAT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MISIFDLVAMLLTLSALFGWINGRFIHMPHSIGMLVLGLVASLLLVLLDVAFPNKHLYEALTGPLRQIDFTDVVMNGMLA
FLLFAGAMTLDLSALRDRAWPVATLALVGTVISTAIVGSAFWAVAQWSGHPVSLAWALVFGALISPTDPVAVLATLKNVK
VPLSLEIEMQGEALFNDGVGIVLFTVLLGFAAGIGGEASSAGGIARLLLQEAGGGLLLGVVTGYVAYRAMRAIDDFPVEV
LITLALVAGTYALAQKLHASGPLAVVAAGLLVGDRAPRDAMSERTQGYVSSLWTLVDEVLNSVLFLLIGLEVLVLRFEAG
SFVLAAAAVPIVLLARLVAVSAPLLAFRWGGNLSARNVPFLTWAGVRGGISVALALSVPESDAKAAILAATYAVVLFTII
VQGSTLAMVARRTLSTPGSG

Sequences:

>Translated_420_residues
MISIFDLVAMLLTLSALFGWINGRFIHMPHSIGMLVLGLVASLLLVLLDVAFPNKHLYEALTGPLRQIDFTDVVMNGMLA
FLLFAGAMTLDLSALRDRAWPVATLALVGTVISTAIVGSAFWAVAQWSGHPVSLAWALVFGALISPTDPVAVLATLKNVK
VPLSLEIEMQGEALFNDGVGIVLFTVLLGFAAGIGGEASSAGGIARLLLQEAGGGLLLGVVTGYVAYRAMRAIDDFPVEV
LITLALVAGTYALAQKLHASGPLAVVAAGLLVGDRAPRDAMSERTQGYVSSLWTLVDEVLNSVLFLLIGLEVLVLRFEAG
SFVLAAAAVPIVLLARLVAVSAPLLAFRWGGNLSARNVPFLTWAGVRGGISVALALSVPESDAKAAILAATYAVVLFTII
VQGSTLAMVARRTLSTPGSG
>Mature_420_residues
MISIFDLVAMLLTLSALFGWINGRFIHMPHSIGMLVLGLVASLLLVLLDVAFPNKHLYEALTGPLRQIDFTDVVMNGMLA
FLLFAGAMTLDLSALRDRAWPVATLALVGTVISTAIVGSAFWAVAQWSGHPVSLAWALVFGALISPTDPVAVLATLKNVK
VPLSLEIEMQGEALFNDGVGIVLFTVLLGFAAGIGGEASSAGGIARLLLQEAGGGLLLGVVTGYVAYRAMRAIDDFPVEV
LITLALVAGTYALAQKLHASGPLAVVAAGLLVGDRAPRDAMSERTQGYVSSLWTLVDEVLNSVLFLLIGLEVLVLRFEAG
SFVLAAAAVPIVLLARLVAVSAPLLAFRWGGNLSARNVPFLTWAGVRGGISVALALSVPESDAKAAILAATYAVVLFTII
VQGSTLAMVARRTLSTPGSG

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=323, Percent_Identity=27.5541795665635, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI15529998, Length=310, Percent_Identity=26.1290322580645, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI14211919, Length=366, Percent_Identity=24.3169398907104, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI294997330, Length=379, Percent_Identity=24.2744063324538, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI110227626, Length=379, Percent_Identity=24.2744063324538, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI5454070, Length=371, Percent_Identity=23.989218328841, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI41872703, Length=344, Percent_Identity=25, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI27734935, Length=357, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790501, Length=310, Percent_Identity=28.0645161290323, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999819, Length=338, Percent_Identity=26.6272189349112, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71999817, Length=338, Percent_Identity=26.6272189349112, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71999821, Length=338, Percent_Identity=26.6272189349112, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25147678, Length=341, Percent_Identity=26.6862170087977, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=324, Percent_Identity=26.5432098765432, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71987537, Length=324, Percent_Identity=26.5432098765432, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25150332, Length=322, Percent_Identity=24.8447204968944, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980847, Length=353, Percent_Identity=24.0793201133144, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990924, Length=355, Percent_Identity=23.0985915492958, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=335, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=355, Percent_Identity=23.0985915492958, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=335, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=350, Percent_Identity=23.1428571428571, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=350, Percent_Identity=23.1428571428571, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=364, Percent_Identity=26.6483516483516, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221473212, Length=352, Percent_Identity=25.8522727272727, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281364513, Length=352, Percent_Identity=25.8522727272727, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221473222, Length=352, Percent_Identity=25.8522727272727, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221473215, Length=352, Percent_Identity=25.8522727272727, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221510740, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24585580, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585578, Length=324, Percent_Identity=25.3086419753086, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221510734, Length=323, Percent_Identity=24.4582043343653, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221510738, Length=323, Percent_Identity=24.4582043343653, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281360447, Length=339, Percent_Identity=24.188790560472, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510732, Length=323, Percent_Identity=24.4582043343653, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510736, Length=323, Percent_Identity=24.4582043343653, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 43777; Mature: 43777

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIFDLVAMLLTLSALFGWINGRFIHMPHSIGMLVLGLVASLLLVLLDVAFPNKHLYEA
CCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTGPLRQIDFTDVVMNGMLAFLLFAGAMTLDLSALRDRAWPVATLALVGTVISTAIVGSA
HCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FWAVAQWSGHPVSLAWALVFGALISPTDPVAVLATLKNVKVPLSLEIEMQGEALFNDGVG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
IVLFTVLLGFAAGIGGEASSAGGIARLLLQEAGGGLLLGVVTGYVAYRAMRAIDDFPVEV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHH
LITLALVAGTYALAQKLHASGPLAVVAAGLLVGDRAPRDAMSERTQGYVSSLWTLVDEVL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NSVLFLLIGLEVLVLRFEAGSFVLAAAAVPIVLLARLVAVSAPLLAFRWGGNLSARNVPF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCE
LTWAGVRGGISVALALSVPESDAKAAILAATYAVVLFTIIVQGSTLAMVARRTLSTPGSG
EEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MISIFDLVAMLLTLSALFGWINGRFIHMPHSIGMLVLGLVASLLLVLLDVAFPNKHLYEA
CCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTGPLRQIDFTDVVMNGMLAFLLFAGAMTLDLSALRDRAWPVATLALVGTVISTAIVGSA
HCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
FWAVAQWSGHPVSLAWALVFGALISPTDPVAVLATLKNVKVPLSLEIEMQGEALFNDGVG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
IVLFTVLLGFAAGIGGEASSAGGIARLLLQEAGGGLLLGVVTGYVAYRAMRAIDDFPVEV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHH
LITLALVAGTYALAQKLHASGPLAVVAAGLLVGDRAPRDAMSERTQGYVSSLWTLVDEVL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NSVLFLLIGLEVLVLRFEAGSFVLAAAAVPIVLLARLVAVSAPLLAFRWGGNLSARNVPF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCE
LTWAGVRGGISVALALSVPESDAKAAILAATYAVVLFTIIVQGSTLAMVARRTLSTPGSG
EEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]