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The map label for this gene is guaA [H]

Identifier: 218531106

GI number: 218531106

Start: 3333353

End: 3334918

Strand: Reverse

Name: guaA [H]

Synonym: Mchl_3156

Alternate gene names: 218531106

Gene position: 3334918-3333353 (Counterclockwise)

Preceding gene: 218531108

Following gene: 218531103

Centisome position: 57.72

GC content: 67.05

Gene sequence:

>1566_bases
ATGACCATCGATACCTCCCACCACGACAAGATCCTGATCGTCGATTTCGGCTCCCAGGTGACGCAGCTCATCGCCCGCCG
CGTGCGCGAGGAGGGCGTCTATTGCGAGATCGTGCCGTTCACGAAGGCCGAGGCCGCTTTTGAGGCGCACCGGCCCAAGG
GCGTGATCCTGTCGGGGGGGCCAGAATCGGTGACGACGGACCTGTCGCCGCGCGCCCCGCAAAAAATCTTCGAATCCGGC
GTGCCGGTCTTCGGCATCTGCTACGGCCAGCAGACCATGGCGGCCCAACTCGGTGGCGAGGTCGAGGGCGGCCACCATGC
CGAGTTCGGCCGCGCCGAGGTCGAGATCGTCTCGGACTCGCCGCTGTTCCGGGGCGTGTGGCACGCGGGCGAGAAGTACC
CGGTCTGGATGAGCCACGGCGACCGGGTGACGAAGCTGCCGGACGGCTTTGCCACCATCGCGATGTCGCGCAATGCACCT
TTCGCCGCGGTGGCGGACGAGGGCCGCCATTACTACGCCGTCCAGTTCCATCCGGAGGTGCACCACACCCCGCACGGCGC
GCTGCTGATCCGCAACTTCGTGCGCGACATCGCCGGCTGCTCCGGCGACTGGACCATGGGCACCTACCGCGAGGAGGCGA
TCGCCAAGATCCGCGAGCAGGTCGGCAAGGAAAAGGTGATCTGCGGCCTCTCCGGCGGCGTCGATTCCTCGGTCGCGGCG
GTGCTGATCCACGAGGCGATCGGCGATCAGCTCACCTGCGTCTTCGTCGATCACGGCCTGATGCGCCTCGGCGAGGGCGA
CGAGGTCGTCCGCCTGTTCCGCGACCACTACAACATCCCCCTCATCCACGTTCAGGCGCAGGATCTGTTCATCGGCGCGC
TCGAGGGCGTCGATGACCCCGAGGTGAAGCGCAAGACGATCGGCCGGCTGTTCATCGACGTGTTCGAGGCGGAGGCCGGC
AAGATCGGCGGCGCCGCCTTCCTCGCCCAGGGCACGCTCTACCCGGACGTGATCGAGAGCGTGTCGTTCTCCGGCGGTCC
CTCCGTGACGATCAAGAGCCACCACAATGTCGGCGGCCTGCCCGAGCGGATGAACATGAAGCTCGTGGAGCCCCTGCGCG
AGCTGTTCAAGGACGAGGTTCGCCTGCTCGGCAAGGAACTCGGCCTGCCCGAGAGCTTCGTCGGCCGCCACCCCTTCCCC
GGACCGGGCCTCGCCATTCGTTGCCCGGGGATGATCACGCGCGAGAAGCTGGAGGCCTTGCGCAAGGCCGACGCGATCTA
TCTCGACGAGATCCGGCAGGCCGGCCTCTACGACACGATCTGGCAGGCCTTCGCCGTGATCCTGCCGGTGAAGACCGTCG
GCGTGATGGGCGACGGGCGCACCTACGACCACGTTTGCGCCCTGCGCGCCGTCACCTCGGTCGATGGCATGACCGCCGAC
TTCTACCCCTTCGACATGGCCTTCCTCGGCCGCGTCGCGACGCGGATCATCAACGAGGTGAAGGGCATCAACCGGGTGAC
CTACGACATCACCTCGAAGCCGCCCGGCACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GGCGGTGACTTGAGGGCCGCCGCATGTGCCTCCTGACCCCAGGCGCGTTGCGCCGTTCCGAGGCCTCGTCTAACCGGTAT
CGCAGAAGGCCCGAGGCAGC

Downstream 100 bases:

>100_bases
GGGCGTTCGTAGCGCCCTTGCTCAGGATCGCTCTACGTCGACCGGATGCACGCTGAGGCGCAATCCTAACGACTTCAGCA
CACCCATGAGCGTGTCGAGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MTIDTSHHDKILIVDFGSQVTQLIARRVREEGVYCEIVPFTKAEAAFEAHRPKGVILSGGPESVTTDLSPRAPQKIFESG
VPVFGICYGQQTMAAQLGGEVEGGHHAEFGRAEVEIVSDSPLFRGVWHAGEKYPVWMSHGDRVTKLPDGFATIAMSRNAP
FAAVADEGRHYYAVQFHPEVHHTPHGALLIRNFVRDIAGCSGDWTMGTYREEAIAKIREQVGKEKVICGLSGGVDSSVAA
VLIHEAIGDQLTCVFVDHGLMRLGEGDEVVRLFRDHYNIPLIHVQAQDLFIGALEGVDDPEVKRKTIGRLFIDVFEAEAG
KIGGAAFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGKELGLPESFVGRHPFP
GPGLAIRCPGMITREKLEALRKADAIYLDEIRQAGLYDTIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTAD
FYPFDMAFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE

Sequences:

>Translated_521_residues
MTIDTSHHDKILIVDFGSQVTQLIARRVREEGVYCEIVPFTKAEAAFEAHRPKGVILSGGPESVTTDLSPRAPQKIFESG
VPVFGICYGQQTMAAQLGGEVEGGHHAEFGRAEVEIVSDSPLFRGVWHAGEKYPVWMSHGDRVTKLPDGFATIAMSRNAP
FAAVADEGRHYYAVQFHPEVHHTPHGALLIRNFVRDIAGCSGDWTMGTYREEAIAKIREQVGKEKVICGLSGGVDSSVAA
VLIHEAIGDQLTCVFVDHGLMRLGEGDEVVRLFRDHYNIPLIHVQAQDLFIGALEGVDDPEVKRKTIGRLFIDVFEAEAG
KIGGAAFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGKELGLPESFVGRHPFP
GPGLAIRCPGMITREKLEALRKADAIYLDEIRQAGLYDTIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTAD
FYPFDMAFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE
>Mature_520_residues
TIDTSHHDKILIVDFGSQVTQLIARRVREEGVYCEIVPFTKAEAAFEAHRPKGVILSGGPESVTTDLSPRAPQKIFESGV
PVFGICYGQQTMAAQLGGEVEGGHHAEFGRAEVEIVSDSPLFRGVWHAGEKYPVWMSHGDRVTKLPDGFATIAMSRNAPF
AAVADEGRHYYAVQFHPEVHHTPHGALLIRNFVRDIAGCSGDWTMGTYREEAIAKIREQVGKEKVICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDHGLMRLGEGDEVVRLFRDHYNIPLIHVQAQDLFIGALEGVDDPEVKRKTIGRLFIDVFEAEAGK
IGGAAFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRLLGKELGLPESFVGRHPFPG
PGLAIRCPGMITREKLEALRKADAIYLDEIRQAGLYDTIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTADF
YPFDMAFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=558, Percent_Identity=36.2007168458781, Blast_Score=295, Evalue=5e-80,
Organism=Escherichia coli, GI1788854, Length=520, Percent_Identity=57.8846153846154, Blast_Score=619, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=36.8881118881119, Blast_Score=294, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=36.8881118881119, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=36.8695652173913, Blast_Score=293, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=52.3076923076923, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281365319, Length=551, Percent_Identity=35.5716878402904, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57110; Mature: 56979

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDTSHHDKILIVDFGSQVTQLIARRVREEGVYCEIVPFTKAEAAFEAHRPKGVILSGG
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEECC
PESVTTDLSPRAPQKIFESGVPVFGICYGQQTMAAQLGGEVEGGHHAEFGRAEVEIVSDS
CCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
PLFRGVWHAGEKYPVWMSHGDRVTKLPDGFATIAMSRNAPFAAVADEGRHYYAVQFHPEV
CHHHHHHHCCCCCEEEECCCCEEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEECCCC
HHTPHGALLIRNFVRDIAGCSGDWTMGTYREEAIAKIREQVGKEKVICGLSGGVDSSVAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
VLIHEAIGDQLTCVFVDHGLMRLGEGDEVVRLFRDHYNIPLIHVQAQDLFIGALEGVDDP
HHHHHHHCCCEEEEEEECCHHCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEHHCCCCCH
EVKRKTIGRLFIDVFEAEAGKIGGAAFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCC
PERMNMKLVEPLRELFKDEVRLLGKELGLPESFVGRHPFPGPGLAIRCPGMITREKLEAL
CHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEECCCCCCHHHHHHH
RKADAIYLDEIRQAGLYDTIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTAD
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCC
FYPFDMAFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TIDTSHHDKILIVDFGSQVTQLIARRVREEGVYCEIVPFTKAEAAFEAHRPKGVILSGG
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEECC
PESVTTDLSPRAPQKIFESGVPVFGICYGQQTMAAQLGGEVEGGHHAEFGRAEVEIVSDS
CCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
PLFRGVWHAGEKYPVWMSHGDRVTKLPDGFATIAMSRNAPFAAVADEGRHYYAVQFHPEV
CHHHHHHHCCCCCEEEECCCCEEEECCCCEEEEEEECCCCEEEEECCCCEEEEEEECCCC
HHTPHGALLIRNFVRDIAGCSGDWTMGTYREEAIAKIREQVGKEKVICGLSGGVDSSVAA
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
VLIHEAIGDQLTCVFVDHGLMRLGEGDEVVRLFRDHYNIPLIHVQAQDLFIGALEGVDDP
HHHHHHHCCCEEEEEEECCHHCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEHHCCCCCH
EVKRKTIGRLFIDVFEAEAGKIGGAAFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCCCCCC
PERMNMKLVEPLRELFKDEVRLLGKELGLPESFVGRHPFPGPGLAIRCPGMITREKLEAL
CHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEECCCCCCHHHHHHH
RKADAIYLDEIRQAGLYDTIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTAD
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCC
FYPFDMAFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA